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- Publisher Website: 10.1161/01.RES.67.2.385
- Scopus: eid_2-s2.0-0025365812
- PMID: 2115821
- WOS: WOS:A1990DU14000015
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Article: Acute impairment of endothelium-dependent relaxations to aggregating platelets following reperfusion injury in canine coronary arteries
Title | Acute impairment of endothelium-dependent relaxations to aggregating platelets following reperfusion injury in canine coronary arteries |
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Authors | |
Keywords | ADP Ischemia Serotonin Thrombosis Vasospasm |
Issue Date | 1990 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://circres.ahajournals.org |
Citation | Circulation Research, 1990, v. 67 n. 2, p. 385-393 How to Cite? |
Abstract | Experiments were designed to determine whether endothelial injury contributes to augmented coronary vascular tone seen during myocardial reperfusion. Canine left anterior descending coronary arteries were exposed to ischemia followed by reperfusion (60 minutes each). Rings (3-4 mm) of the reperfused artery and of normal left circumflex (control) coronary artery segments were prepared. Rings were suspended for isometric force measurement in organ chamber containing modified Krebs' Ringer bicarbonate solution (37°C, 95%, O2-5% CO2). Endothelium-independent contractions to KCl and prostaglandin F(2α) were unaltered after reperfusion. Endothelium-dependent relaxations to nitric oxide, sodium nitroprusside, and isoproterenol were comparable in control and reperfused arteries. However, reperfused coronary arteries contracted with prostaglandin F(2α) lost the ability to express endothelium-dependent relaxations to aggregating platelets. Reperfused arterial rings also exhibited impaired endothelium-dependent relaxations to acetylcholine, the calcium ionophore A23187, and the platelet-derived compounds ADP and serotonin. Quiescent (noncontracted) reperfused arterial rings exhibited larger conractions than controls when exposed to aggregating platelets. In such quiescent rings, the endothelium-dependent increase in tension to hemoglobin was unaltered after reperfusion. Thus, coronary reperfusion impairs the normal endothelium-dependent relaxations to aggregating platelets and vasoactive drugs. This impairment of platelet-mediated coronary relaxtion could help explain the increased vascular tone and tendency toward vasospasm commonly observed after reperfusion of the coronary arteries. |
Persistent Identifier | http://hdl.handle.net/10722/170995 |
ISSN | 2023 Impact Factor: 16.5 2023 SCImago Journal Rankings: 4.903 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Pearson, PJ | en_US |
dc.contributor.author | Schaff, HV | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:11:45Z | - |
dc.date.available | 2012-10-30T06:11:45Z | - |
dc.date.issued | 1990 | en_US |
dc.identifier.citation | Circulation Research, 1990, v. 67 n. 2, p. 385-393 | en_US |
dc.identifier.issn | 0009-7330 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170995 | - |
dc.description.abstract | Experiments were designed to determine whether endothelial injury contributes to augmented coronary vascular tone seen during myocardial reperfusion. Canine left anterior descending coronary arteries were exposed to ischemia followed by reperfusion (60 minutes each). Rings (3-4 mm) of the reperfused artery and of normal left circumflex (control) coronary artery segments were prepared. Rings were suspended for isometric force measurement in organ chamber containing modified Krebs' Ringer bicarbonate solution (37°C, 95%, O2-5% CO2). Endothelium-independent contractions to KCl and prostaglandin F(2α) were unaltered after reperfusion. Endothelium-dependent relaxations to nitric oxide, sodium nitroprusside, and isoproterenol were comparable in control and reperfused arteries. However, reperfused coronary arteries contracted with prostaglandin F(2α) lost the ability to express endothelium-dependent relaxations to aggregating platelets. Reperfused arterial rings also exhibited impaired endothelium-dependent relaxations to acetylcholine, the calcium ionophore A23187, and the platelet-derived compounds ADP and serotonin. Quiescent (noncontracted) reperfused arterial rings exhibited larger conractions than controls when exposed to aggregating platelets. In such quiescent rings, the endothelium-dependent increase in tension to hemoglobin was unaltered after reperfusion. Thus, coronary reperfusion impairs the normal endothelium-dependent relaxations to aggregating platelets and vasoactive drugs. This impairment of platelet-mediated coronary relaxtion could help explain the increased vascular tone and tendency toward vasospasm commonly observed after reperfusion of the coronary arteries. | en_US |
dc.language | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://circres.ahajournals.org | en_US |
dc.relation.ispartof | Circulation Research | en_US |
dc.subject | ADP | - |
dc.subject | Ischemia | - |
dc.subject | Serotonin | - |
dc.subject | Thrombosis | - |
dc.subject | Vasospasm | - |
dc.subject.mesh | Acetylcholine - Pharmacology | en_US |
dc.subject.mesh | Adenosine Diphosphate - Pharmacology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Calcimycin - Pharmacology | en_US |
dc.subject.mesh | Coronary Vessels - Drug Effects - Physiology - Physiopathology | en_US |
dc.subject.mesh | Dinoprost - Pharmacology | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Endothelium, Vascular - Physiology - Physiopathology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Hemoglobins - Pharmacology | en_US |
dc.subject.mesh | Isoproterenol - Pharmacology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Muscle, Smooth, Vascular - Drug Effects - Physiology - Physiopathology | en_US |
dc.subject.mesh | Myocardial Reperfusion Injury - Physiopathology | en_US |
dc.subject.mesh | Nitric Oxide - Pharmacology | en_US |
dc.subject.mesh | Platelet Aggregation | en_US |
dc.subject.mesh | Potassium - Pharmacology | en_US |
dc.subject.mesh | Serotonin - Pharmacology | en_US |
dc.title | Acute impairment of endothelium-dependent relaxations to aggregating platelets following reperfusion injury in canine coronary arteries | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1161/01.RES.67.2.385 | - |
dc.identifier.pmid | 2115821 | - |
dc.identifier.scopus | eid_2-s2.0-0025365812 | en_US |
dc.identifier.volume | 67 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 385 | en_US |
dc.identifier.epage | 393 | en_US |
dc.identifier.isi | WOS:A1990DU14000015 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Pearson, PJ=7202175749 | en_US |
dc.identifier.scopusauthorid | Schaff, HV=36041155600 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0009-7330 | - |