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Article: Pertussis toxin inhibits endothelium-dependent relaxations evoked by fluoride

TitlePertussis toxin inhibits endothelium-dependent relaxations evoked by fluoride
Authors
Flavahan, NAVanhoutte, PM
KeywordsBacterial toxins
EDRF
Endothelium-derived relaxing factor
G-proteins
guanine nucleotide regulatory proteins
Issue Date1990
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar
Citation
European Journal Of Pharmacology, 1990, v. 178 n. 1, p. 121-124 How to Cite?
DOI: http://dx.doi.org/10.1016/0014-2999(90)94803-6
AbstractFluoride is a direct activator of G-proteins. In isolated rings of canine coronary artery, fluoride caused relaxation of rings with endothelium, but only slight contraction of rings denuded of endothelium. The endothelium-dependent relaxations to fluoride were inhibited by pertussis toxin, an inhibitor of G-proteins, or by methylene blue, an inhibitor of soluble guanylate cyclase. Therefore, fluoride causes endothelium-dependent relaxations in part by activating a pertussis toxin-sensitive G-protein in the endothelial cells.
Persistent Identifierhttp://hdl.handle.net/10722/170981
ISSN
0014-2999
2023 Impact Factor: 4.2
2023 SCImago Journal Rankings: 1.055
ISI Accession Number ID
WOS:A1990CW70000017

 

DC FieldValueLanguage
dc.contributor.authorFlavahan, NAen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:42Z-
dc.date.available2012-10-30T06:11:42Z-
dc.date.issued1990en_US
dc.identifier.citationEuropean Journal Of Pharmacology, 1990, v. 178 n. 1, p. 121-124en_US
dc.identifier.issn0014-2999en_US
dc.identifier.urihttp://hdl.handle.net/10722/170981-
dc.description.abstractFluoride is a direct activator of G-proteins. In isolated rings of canine coronary artery, fluoride caused relaxation of rings with endothelium, but only slight contraction of rings denuded of endothelium. The endothelium-dependent relaxations to fluoride were inhibited by pertussis toxin, an inhibitor of G-proteins, or by methylene blue, an inhibitor of soluble guanylate cyclase. Therefore, fluoride causes endothelium-dependent relaxations in part by activating a pertussis toxin-sensitive G-protein in the endothelial cells.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejpharen_US
dc.relation.ispartofEuropean Journal of Pharmacologyen_US
dc.subjectBacterial toxins-
dc.subjectEDRF-
dc.subjectEndothelium-derived relaxing factor-
dc.subjectG-proteins-
dc.subjectguanine nucleotide regulatory proteins-
dc.subject.meshAcetylcholine - Pharmacologyen_US
dc.subject.meshAluminum - Pharmacologyen_US
dc.subject.meshAluminum Compoundsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshChlorides - Pharmacologyen_US
dc.subject.meshCoronary Vessels - Drug Effectsen_US
dc.subject.meshDinoprost - Pharmacologyen_US
dc.subject.meshDogsen_US
dc.subject.meshFemaleen_US
dc.subject.meshFluorides - Pharmacologyen_US
dc.subject.meshGtp-Binding Proteins - Pharmacologyen_US
dc.subject.meshIndomethacin - Pharmacologyen_US
dc.subject.meshMaleen_US
dc.subject.meshMethylene Blue - Pharmacologyen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle Relaxation - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effectsen_US
dc.subject.meshNitric Oxide - Antagonists & Inhibitorsen_US
dc.subject.meshNitroglycerin - Pharmacologyen_US
dc.subject.meshPertussis Toxinen_US
dc.subject.meshPropranolol - Pharmacologyen_US
dc.subject.meshVirulence Factors, Bordetella - Pharmacologyen_US
dc.titlePertussis toxin inhibits endothelium-dependent relaxations evoked by fluorideen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0014-2999(90)94803-6-
dc.identifier.pmid2110066-
dc.identifier.scopuseid_2-s2.0-0025215171en_US
dc.identifier.volume178en_US
dc.identifier.issue1en_US
dc.identifier.spage121en_US
dc.identifier.epage124en_US
dc.identifier.isiWOS:A1990CW70000017-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridFlavahan, NA=7006398882en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.issnl0014-2999-

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