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Article: Similar responsiveness of smooth muscle of the canine basilar artery to EDRF and nitric oxide

TitleSimilar responsiveness of smooth muscle of the canine basilar artery to EDRF and nitric oxide
Authors
Katusic, ZSMarshall, JJKontos, HAVanhoutte, PM
Issue Date1989
PublisherAmerican Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/
Citation
American Journal Of Physiology - Heart And Circulatory Physiology, 1989, v. 257 n. 4, p. 26/4 How to Cite?
AbstractExperiments were designed to compare the reactivity of canine basilar arteries to endothelium-derived relaxing factor (EDRF) and nitric oxide. Preparations with endothelium activated by bradykinin were used to study relaxations induced with EDRF, whereas the inhibitory effect of nitric oxide was studied in preparations without endothelium. All experiments were performed in the presence of indomethacin. EDRF- and nitric oxide-induced relaxations were significantly augmented in the presence of superoxide dismutase plus catalase but were reduced in the presence of methylene blue, LY 83583, and hemoglobin. M and B 22984 did not affect relaxations to either EDRF or nitric oxide. These results indicate that in the canine basilar artery EDRF is not an oxygen-derived free radical. The similar responsiveness of the basilar artery to EDRF and nitric oxide is consistent with the proposal that in the canine basilar artery nitric oxide is the factor.
Persistent Identifierhttp://hdl.handle.net/10722/170942
ISSN
0002-9513

 

DC FieldValueLanguage
dc.contributor.authorKatusic, ZSen_US
dc.contributor.authorMarshall, JJen_US
dc.contributor.authorKontos, HAen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:32Z-
dc.date.available2012-10-30T06:11:32Z-
dc.date.issued1989en_US
dc.identifier.citationAmerican Journal Of Physiology - Heart And Circulatory Physiology, 1989, v. 257 n. 4, p. 26/4en_US
dc.identifier.issn0002-9513en_US
dc.identifier.urihttp://hdl.handle.net/10722/170942-
dc.description.abstractExperiments were designed to compare the reactivity of canine basilar arteries to endothelium-derived relaxing factor (EDRF) and nitric oxide. Preparations with endothelium activated by bradykinin were used to study relaxations induced with EDRF, whereas the inhibitory effect of nitric oxide was studied in preparations without endothelium. All experiments were performed in the presence of indomethacin. EDRF- and nitric oxide-induced relaxations were significantly augmented in the presence of superoxide dismutase plus catalase but were reduced in the presence of methylene blue, LY 83583, and hemoglobin. M and B 22984 did not affect relaxations to either EDRF or nitric oxide. These results indicate that in the canine basilar artery EDRF is not an oxygen-derived free radical. The similar responsiveness of the basilar artery to EDRF and nitric oxide is consistent with the proposal that in the canine basilar artery nitric oxide is the factor.en_US
dc.languageengen_US
dc.publisherAmerican Physiological Society. The Journal's web site is located at http://ajpcon.physiology.org/en_US
dc.relation.ispartofAmerican Journal of Physiology - Heart and Circulatory Physiologyen_US
dc.subject.mesh3',5'-Cyclic-Amp Phosphodiesterases - Antagonists & Inhibitorsen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBasilar Artery - Drug Effects - Physiologyen_US
dc.subject.meshBradykinin - Pharmacologyen_US
dc.subject.meshDogsen_US
dc.subject.meshEndothelium, Vascular - Physiologyen_US
dc.subject.meshKineticsen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effects - Physiologyen_US
dc.subject.meshNitric Oxide - Pharmacology - Physiologyen_US
dc.subject.meshPurinones - Pharmacologyen_US
dc.subject.meshVasodilation - Drug Effectsen_US
dc.titleSimilar responsiveness of smooth muscle of the canine basilar artery to EDRF and nitric oxideen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2552840-
dc.identifier.scopuseid_2-s2.0-0024460847en_US
dc.identifier.volume257en_US
dc.identifier.issue4en_US
dc.identifier.spage26/4en_US
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridKatusic, ZS=7006971465en_US
dc.identifier.scopusauthoridMarshall, JJ=35396908600en_US
dc.identifier.scopusauthoridKontos, HA=7102589474en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.issnl0002-9513-

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