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- Publisher Website: 10.1097/00005344-198812081-00004
- Scopus: eid_2-s2.0-0024271322
- PMID: 2469892
- WOS: WOS:A1988T261600003
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Article: Aging and vascular responsiveness
Title | Aging and vascular responsiveness |
---|---|
Authors | |
Keywords | Cyclic nucleotides Endothelium-dependent contractions and relaxations Na<sup>+</sup> K<sup>+</sup> -pump Norepinephrine Pre- and postjunctional receptors Vasodilator nerves α-Adrenoceptors β-adrenoceptors |
Issue Date | 1988 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/ |
Citation | Journal Of Cardiovascular Pharmacology, 1988, v. 12 SUPPL. 8, p. S11-S18 How to Cite? |
Abstract | With aging, the blood vessel wall becomes hyperreactive - presumably because of an augmented vasoconstrictor and a reduced vasodilator responsiveness. Autonomic nerves, vascular smooth muscle, and endothelial cells may contribute to these changes. It seems unlikely that augmented vasoconstriction following α-adrenergic activation plays a major role in the increased peripheral resistance seen in the elderly human. There are no major age-related changes in the responsiveness of vascular smooth muscle to angiotensin II, histamine, or potassium chloride. By contrast, the vasoconstrictor effects of 5-hydroxytryptamine (serotonin) are augmented, and the tachyphylaxis to the monoamine is reduced with aging. There are no indications of a major abnormality in either response to vasodilator nerves or endothelium-dependent vasodilators. However, the α-adrenergic responsiveness of most arteries is reduced, whereas that of the veins is not affected by age. When it is exposed to agents acting directly, arterial smooth muscle's ability to relax is not altered with senescence. Thus, the augmented responsiveness to the vasoconstrictor effects of serotonin and the reduced response to the β-adrenergic dilator effects of catecholamines appear to be the hallmark of aging in the precapillary vessels. |
Persistent Identifier | http://hdl.handle.net/10722/170915 |
ISSN | 2023 Impact Factor: 2.6 2023 SCImago Journal Rankings: 0.610 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:11:25Z | - |
dc.date.available | 2012-10-30T06:11:25Z | - |
dc.date.issued | 1988 | en_US |
dc.identifier.citation | Journal Of Cardiovascular Pharmacology, 1988, v. 12 SUPPL. 8, p. S11-S18 | en_US |
dc.identifier.issn | 0160-2446 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170915 | - |
dc.description.abstract | With aging, the blood vessel wall becomes hyperreactive - presumably because of an augmented vasoconstrictor and a reduced vasodilator responsiveness. Autonomic nerves, vascular smooth muscle, and endothelial cells may contribute to these changes. It seems unlikely that augmented vasoconstriction following α-adrenergic activation plays a major role in the increased peripheral resistance seen in the elderly human. There are no major age-related changes in the responsiveness of vascular smooth muscle to angiotensin II, histamine, or potassium chloride. By contrast, the vasoconstrictor effects of 5-hydroxytryptamine (serotonin) are augmented, and the tachyphylaxis to the monoamine is reduced with aging. There are no indications of a major abnormality in either response to vasodilator nerves or endothelium-dependent vasodilators. However, the α-adrenergic responsiveness of most arteries is reduced, whereas that of the veins is not affected by age. When it is exposed to agents acting directly, arterial smooth muscle's ability to relax is not altered with senescence. Thus, the augmented responsiveness to the vasoconstrictor effects of serotonin and the reduced response to the β-adrenergic dilator effects of catecholamines appear to be the hallmark of aging in the precapillary vessels. | en_US |
dc.language | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/ | en_US |
dc.relation.ispartof | Journal of Cardiovascular Pharmacology | en_US |
dc.subject | Cyclic nucleotides | - |
dc.subject | Endothelium-dependent contractions and relaxations | - |
dc.subject | Na<sup>+</sup> K<sup>+</sup> -pump | - |
dc.subject | Norepinephrine | - |
dc.subject | Pre- and postjunctional receptors | - |
dc.subject | Vasodilator nerves | - |
dc.subject | α-Adrenoceptors | - |
dc.subject | β-adrenoceptors | - |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Aging - Physiology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Cardiovascular Physiological Phenomena | en_US |
dc.subject.mesh | Humans | en_US |
dc.title | Aging and vascular responsiveness | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1097/00005344-198812081-00004 | - |
dc.identifier.pmid | 2469892 | - |
dc.identifier.scopus | eid_2-s2.0-0024271322 | en_US |
dc.identifier.volume | 12 | en_US |
dc.identifier.issue | SUPPL. 8 | en_US |
dc.identifier.spage | S11 | en_US |
dc.identifier.epage | S18 | en_US |
dc.identifier.isi | WOS:A1988T261600003 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0160-2446 | - |