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- Publisher Website: 10.1161/01.RES.63.3.604
- Scopus: eid_2-s2.0-0023762713
- PMID: 3409491
- WOS: WOS:A1988P999600012
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Article: Endothelium-dependent relaxation to aggregating platelets in isolated basilar arteries of control and hypercholesterolemic pigs
Title | Endothelium-dependent relaxation to aggregating platelets in isolated basilar arteries of control and hypercholesterolemic pigs |
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Authors | |
Issue Date | 1988 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://circres.ahajournals.org |
Citation | Circulation Research, 1988, v. 63 n. 3, p. 604-612 How to Cite? |
Abstract | The role of the endothelium was examined in the response to aggregating platelets in cerebral arteries from normal and hypercholesterolemic animals. Male Yorkshire pigs were fed either a normal diet or a 2% high-cholesterol diet for 10 weeks. Endothelium-dependent responses were examined in vitro. In rings of basilar arteries from control animals aggregating platelets caused endothelium-dependent relaxations, which were significantly inhibited by apyrase, an adenosine diphosphatase and triphosphatase, but were augmented by methiothepin, a combined S1- and S2-serotonergic blocker. In quiescent rings platelets induced contractions that were inhibited by the presence of the endothelium; these contractions were significantly inhibited by methiothepin, but not by ketanserin (an S2-serotonergic blocker) or dazoxiben (a thromboxane-synthetase blocker) in the presence or absence of SQ29548 (a thromboxane-receptor blocker). Adenosine diphosphate but not serotonin caused endothelium-dependent relaxations. In cholesterol-fed animals the endothelium-dependent relaxations in response to aggregating platelets and adenosine diphosphate were impaired. These experiments indicate that 1) the endothelium inhibits the vasoconstrictor effect of aggregating platelets in porcine cerebral arteries; 2) platelet-induced relaxations are achieved mainly by a purinergic mechanism, while platelet-induced contractions are mediated by activation of S1-serotonergic receptors with little contribution of thromboxanes; and 3) hypercholesterolemia impairs the endothelium-dependent relaxations in response to aggregating platelets due to the impaired responses to adenosine diphosphate. |
Persistent Identifier | http://hdl.handle.net/10722/170879 |
ISSN | 2023 Impact Factor: 16.5 2023 SCImago Journal Rankings: 4.903 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shimokawa, H | en_US |
dc.contributor.author | Kim, P | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:11:15Z | - |
dc.date.available | 2012-10-30T06:11:15Z | - |
dc.date.issued | 1988 | en_US |
dc.identifier.citation | Circulation Research, 1988, v. 63 n. 3, p. 604-612 | en_US |
dc.identifier.issn | 0009-7330 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170879 | - |
dc.description.abstract | The role of the endothelium was examined in the response to aggregating platelets in cerebral arteries from normal and hypercholesterolemic animals. Male Yorkshire pigs were fed either a normal diet or a 2% high-cholesterol diet for 10 weeks. Endothelium-dependent responses were examined in vitro. In rings of basilar arteries from control animals aggregating platelets caused endothelium-dependent relaxations, which were significantly inhibited by apyrase, an adenosine diphosphatase and triphosphatase, but were augmented by methiothepin, a combined S1- and S2-serotonergic blocker. In quiescent rings platelets induced contractions that were inhibited by the presence of the endothelium; these contractions were significantly inhibited by methiothepin, but not by ketanserin (an S2-serotonergic blocker) or dazoxiben (a thromboxane-synthetase blocker) in the presence or absence of SQ29548 (a thromboxane-receptor blocker). Adenosine diphosphate but not serotonin caused endothelium-dependent relaxations. In cholesterol-fed animals the endothelium-dependent relaxations in response to aggregating platelets and adenosine diphosphate were impaired. These experiments indicate that 1) the endothelium inhibits the vasoconstrictor effect of aggregating platelets in porcine cerebral arteries; 2) platelet-induced relaxations are achieved mainly by a purinergic mechanism, while platelet-induced contractions are mediated by activation of S1-serotonergic receptors with little contribution of thromboxanes; and 3) hypercholesterolemia impairs the endothelium-dependent relaxations in response to aggregating platelets due to the impaired responses to adenosine diphosphate. | en_US |
dc.language | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://circres.ahajournals.org | en_US |
dc.relation.ispartof | Circulation Research | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Basilar Artery - Physiology - Physiopathology | en_US |
dc.subject.mesh | Blood Platelets - Physiology | en_US |
dc.subject.mesh | Endothelium, Vascular - Physiology - Physiopathology | en_US |
dc.subject.mesh | Hypercholesterolemia - Physiopathology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Platelet Aggregation | en_US |
dc.subject.mesh | Reference Values | en_US |
dc.subject.mesh | Swine | en_US |
dc.subject.mesh | Vasoconstriction | en_US |
dc.subject.mesh | Vasodilation | en_US |
dc.title | Endothelium-dependent relaxation to aggregating platelets in isolated basilar arteries of control and hypercholesterolemic pigs | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1161/01.RES.63.3.604 | - |
dc.identifier.pmid | 3409491 | - |
dc.identifier.scopus | eid_2-s2.0-0023762713 | en_US |
dc.identifier.volume | 63 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 604 | en_US |
dc.identifier.epage | 612 | en_US |
dc.identifier.isi | WOS:A1988P999600012 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Shimokawa, H=16684837100 | en_US |
dc.identifier.scopusauthorid | Kim, P=7402334666 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0009-7330 | - |