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Article: Threshold phenomena and interactions between receptors

TitleThreshold phenomena and interactions between receptors
Authors
Flavahan, NAVanhoutte, PM
Issue Date1988
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/
Citation
Journal Of Cardiovascular Pharmacology, 1988, v. 11 SUPPL. 1, p. S67-S72 How to Cite?
AbstractThreshold or subthreshold concentrations of serotonin can augment contractile responses of isolated blood vessels to other vasoconstrictor agents. This report presents a theoretical analysis of threshold facilitation and concludes that the amplifying effect of serotonin may result from the removal of a response threshold. Physiological or pathophysiological alterations in the magnitude of this response threshold between different effector systems or in the efficacy of the vasoconstrictor agonist may account for the variability in the amplifying effect of serotonin observed in vivo and in vitro.
Persistent Identifierhttp://hdl.handle.net/10722/170877
ISSN
0160-2446
2021 Impact Factor: 3.271
2020 SCImago Journal Rankings: 0.762
ISI Accession Number ID
WOS:A1988P544300015

 

DC FieldValueLanguage
dc.contributor.authorFlavahan, NAen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:11:14Z-
dc.date.available2012-10-30T06:11:14Z-
dc.date.issued1988en_US
dc.identifier.citationJournal Of Cardiovascular Pharmacology, 1988, v. 11 SUPPL. 1, p. S67-S72en_US
dc.identifier.issn0160-2446en_US
dc.identifier.urihttp://hdl.handle.net/10722/170877-
dc.description.abstractThreshold or subthreshold concentrations of serotonin can augment contractile responses of isolated blood vessels to other vasoconstrictor agents. This report presents a theoretical analysis of threshold facilitation and concludes that the amplifying effect of serotonin may result from the removal of a response threshold. Physiological or pathophysiological alterations in the magnitude of this response threshold between different effector systems or in the efficacy of the vasoconstrictor agonist may account for the variability in the amplifying effect of serotonin observed in vivo and in vitro.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/en_US
dc.relation.ispartofJournal of Cardiovascular Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshHumansen_US
dc.subject.meshReceptors, Serotonin - Physiologyen_US
dc.subject.meshSerotonin - Physiologyen_US
dc.subject.meshSerotonin Antagonists - Pharmacologyen_US
dc.subject.meshVasoconstriction - Drug Effectsen_US
dc.subject.meshVasoconstrictor Agents - Pharmacologyen_US
dc.titleThreshold phenomena and interactions between receptorsen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.pmid2459519-
dc.identifier.scopuseid_2-s2.0-0023758696en_US
dc.identifier.volume11en_US
dc.identifier.issueSUPPL. 1en_US
dc.identifier.spageS67en_US
dc.identifier.epageS72en_US
dc.identifier.isiWOS:A1988P544300015-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridFlavahan, NA=7006398882en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.issnl0160-2446-

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