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- Scopus: eid_2-s2.0-0023758696
- PMID: 2459519
- WOS: WOS:A1988P544300015
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Article: Threshold phenomena and interactions between receptors
Title | Threshold phenomena and interactions between receptors |
---|---|
Authors | |
Issue Date | 1988 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/ |
Citation | Journal Of Cardiovascular Pharmacology, 1988, v. 11 SUPPL. 1, p. S67-S72 How to Cite? |
Abstract | Threshold or subthreshold concentrations of serotonin can augment contractile responses of isolated blood vessels to other vasoconstrictor agents. This report presents a theoretical analysis of threshold facilitation and concludes that the amplifying effect of serotonin may result from the removal of a response threshold. Physiological or pathophysiological alterations in the magnitude of this response threshold between different effector systems or in the efficacy of the vasoconstrictor agonist may account for the variability in the amplifying effect of serotonin observed in vivo and in vitro. |
Persistent Identifier | http://hdl.handle.net/10722/170877 |
ISSN | 2023 Impact Factor: 2.6 2023 SCImago Journal Rankings: 0.610 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Flavahan, NA | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:11:14Z | - |
dc.date.available | 2012-10-30T06:11:14Z | - |
dc.date.issued | 1988 | en_US |
dc.identifier.citation | Journal Of Cardiovascular Pharmacology, 1988, v. 11 SUPPL. 1, p. S67-S72 | en_US |
dc.identifier.issn | 0160-2446 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170877 | - |
dc.description.abstract | Threshold or subthreshold concentrations of serotonin can augment contractile responses of isolated blood vessels to other vasoconstrictor agents. This report presents a theoretical analysis of threshold facilitation and concludes that the amplifying effect of serotonin may result from the removal of a response threshold. Physiological or pathophysiological alterations in the magnitude of this response threshold between different effector systems or in the efficacy of the vasoconstrictor agonist may account for the variability in the amplifying effect of serotonin observed in vivo and in vitro. | en_US |
dc.language | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/ | en_US |
dc.relation.ispartof | Journal of Cardiovascular Pharmacology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Receptors, Serotonin - Physiology | en_US |
dc.subject.mesh | Serotonin - Physiology | en_US |
dc.subject.mesh | Serotonin Antagonists - Pharmacology | en_US |
dc.subject.mesh | Vasoconstriction - Drug Effects | en_US |
dc.subject.mesh | Vasoconstrictor Agents - Pharmacology | en_US |
dc.title | Threshold phenomena and interactions between receptors | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 2459519 | - |
dc.identifier.scopus | eid_2-s2.0-0023758696 | en_US |
dc.identifier.volume | 11 | en_US |
dc.identifier.issue | SUPPL. 1 | en_US |
dc.identifier.spage | S67 | en_US |
dc.identifier.epage | S72 | en_US |
dc.identifier.isi | WOS:A1988P544300015 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Flavahan, NA=7006398882 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0160-2446 | - |