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- Publisher Website: 10.1161/01.HYP.11.6.573
- Scopus: eid_2-s2.0-0023755072
- PMID: 3260580
- WOS: WOS:A1988P204500003
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Article: Endothelium-dependent responses in carotid and renal arteries of normotensive and hypertensive rats
Title | Endothelium-dependent responses in carotid and renal arteries of normotensive and hypertensive rats |
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Authors | |
Keywords | Acetylcholine Adenosine 5′-diphosphate Indomethacin Prostaglandins Serotonin Sodium nitroprusside Spontaneously hypertensive rats Wistar-kyoto rats |
Issue Date | 1988 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://hyper.ahajournals.org/ |
Citation | Hypertension, 1988, v. 11 n. 6 PART 2, p. 573-578 How to Cite? |
Abstract | Endothelium-dependent relaxations are impaired in the aorta of various models of hypertension, but no data are available regarding the cerebral or renal circulation. Endothelium-dependent relaxations were studied in the carotid and renal artery of Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). Rings with and without endothelium were suspended in organ chambers for isometric tension recording. Acetylcholine and adenosine 5'-diphosphate (ADP) caused endothelium-dependent relaxations in both arteries that were impaired in the carotid, but not in the renal artery, of the SHR, similar to those to the endothelium-independent vasodilator sodium nitroprusside. Indomethacin did not affect relaxations to acetylcholine in the carotid artery, but it significantly augmented them in the renal artery. This finding suggests that an impaired vascular responsiveness to endothelium-derived relaxing factor is responsible for the decreased relaxations in the carotid artery of the SHR. In the renal artery, acetylcholine appears to release both endothelium-derived relaxing factor and a vasoconstrictor prostanoid. Carotid arteries of SHR were more sensitive to the constrictor effects of serotonin than were those of WKY. Endothelium removal caused a twofold to eightfold increase in sensitivity to serotonin in both strains. Thus, the endothelium-dependent relaxations to acetylcholine and ADP are reduced and constrictions to serotonin are enhanced in the carotid, but not in the renal, artery of the SHR. |
Persistent Identifier | http://hdl.handle.net/10722/170875 |
ISSN | 2021 Impact Factor: 9.897 2020 SCImago Journal Rankings: 2.986 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Luscher, TF | en_US |
dc.contributor.author | Diederich, D | en_US |
dc.contributor.author | Weber, E | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.contributor.author | Buhler, FR | en_US |
dc.date.accessioned | 2012-10-30T06:11:14Z | - |
dc.date.available | 2012-10-30T06:11:14Z | - |
dc.date.issued | 1988 | en_US |
dc.identifier.citation | Hypertension, 1988, v. 11 n. 6 PART 2, p. 573-578 | en_US |
dc.identifier.issn | 0194-911X | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170875 | - |
dc.description.abstract | Endothelium-dependent relaxations are impaired in the aorta of various models of hypertension, but no data are available regarding the cerebral or renal circulation. Endothelium-dependent relaxations were studied in the carotid and renal artery of Wistar-Kyoto rats (WKY) and spontaneously hypertensive rats (SHR). Rings with and without endothelium were suspended in organ chambers for isometric tension recording. Acetylcholine and adenosine 5'-diphosphate (ADP) caused endothelium-dependent relaxations in both arteries that were impaired in the carotid, but not in the renal artery, of the SHR, similar to those to the endothelium-independent vasodilator sodium nitroprusside. Indomethacin did not affect relaxations to acetylcholine in the carotid artery, but it significantly augmented them in the renal artery. This finding suggests that an impaired vascular responsiveness to endothelium-derived relaxing factor is responsible for the decreased relaxations in the carotid artery of the SHR. In the renal artery, acetylcholine appears to release both endothelium-derived relaxing factor and a vasoconstrictor prostanoid. Carotid arteries of SHR were more sensitive to the constrictor effects of serotonin than were those of WKY. Endothelium removal caused a twofold to eightfold increase in sensitivity to serotonin in both strains. Thus, the endothelium-dependent relaxations to acetylcholine and ADP are reduced and constrictions to serotonin are enhanced in the carotid, but not in the renal, artery of the SHR. | en_US |
dc.language | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://hyper.ahajournals.org/ | en_US |
dc.relation.ispartof | Hypertension | en_US |
dc.subject | Acetylcholine | - |
dc.subject | Adenosine 5′-diphosphate | - |
dc.subject | Indomethacin | - |
dc.subject | Prostaglandins | - |
dc.subject | Serotonin | - |
dc.subject | Sodium nitroprusside | - |
dc.subject | Spontaneously hypertensive rats | - |
dc.subject | Wistar-kyoto rats | - |
dc.subject.mesh | Acetylcholine - Pharmacology | en_US |
dc.subject.mesh | Adenosine Diphosphate - Pharmacology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Biological Agents - Physiology | en_US |
dc.subject.mesh | Carotid Arteries - Physiopathology | en_US |
dc.subject.mesh | Endothelium, Vascular - Physiopathology | en_US |
dc.subject.mesh | Hypertension - Physiopathology | en_US |
dc.subject.mesh | Indomethacin - Pharmacology | en_US |
dc.subject.mesh | Isometric Contraction - Drug Effects | en_US |
dc.subject.mesh | Muscle, Smooth, Vascular - Drug Effects - Physiopathology | en_US |
dc.subject.mesh | Nitric Oxide | en_US |
dc.subject.mesh | Nitroprusside - Pharmacology | en_US |
dc.subject.mesh | Norepinephrine - Pharmacology | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Inbred Shr - Physiology | en_US |
dc.subject.mesh | Rats, Inbred Strains - Physiology | en_US |
dc.subject.mesh | Rats, Inbred Wky - Physiology | en_US |
dc.subject.mesh | Renal Artery - Physiopathology | en_US |
dc.subject.mesh | Serotonin - Pharmacology | en_US |
dc.title | Endothelium-dependent responses in carotid and renal arteries of normotensive and hypertensive rats | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1161/01.HYP.11.6.573 | - |
dc.identifier.pmid | 3260580 | - |
dc.identifier.scopus | eid_2-s2.0-0023755072 | en_US |
dc.identifier.volume | 11 | en_US |
dc.identifier.issue | 6 PART 2 | en_US |
dc.identifier.spage | 573 | en_US |
dc.identifier.epage | 578 | en_US |
dc.identifier.isi | WOS:A1988P204500003 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Luscher, TF=18935805600 | en_US |
dc.identifier.scopusauthorid | Diederich, D=7004821557 | en_US |
dc.identifier.scopusauthorid | Weber, E=7401971488 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.scopusauthorid | Buhler, FR=8838192300 | en_US |
dc.identifier.issnl | 0194-911X | - |