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Article: Antihypertensive treatment normalizes decreased endothelium-dependent relaxations in rats with salt-induced hypertension
Title | Antihypertensive treatment normalizes decreased endothelium-dependent relaxations in rats with salt-induced hypertension |
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Authors | |
Keywords | Acetylcholine Adenosine 5'-diphosphate Dahl rats Norepinephrine Sodium nitroprusside Thoracic aorta Thrombin |
Issue Date | 1987 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://hyper.ahajournals.org/ |
Citation | Hypertension, 1987, v. 9 n. 6 II SUPPL., p. III-193-III-197 How to Cite? |
Abstract | Endothelium-dependent responses are impaired in various models of hypertension. The effects of antihypertensive treatment on endothelium-dependent relaxations were studied in Dahl salt-sensitive (DS) and Dahl salt-resistant rats (DR) on a high or low sodium diet. The rats were given either a diet containing 8% NaCl or 0.1% NaCl for 8 weeks or a diet containing 8% NaCl and a combination of reserpine, hydrochlorothiazide, and hydralazine for 8 or 2 weeks. DS on the 8% NaCl diet developed hypertension, while the other rats did not. Antihypertensive therapy for 8 or 2 weeks prevented or reversed hypertension in DS and lowered blood pressure in DR on the 8% NaCl diet. Aortic rings with and without endothelium were suspended in organ chambers for isometric tension recording. In all groups, acetylcholine, adenosine 5'-diphosphate, and thrombin caused endothelium-dependent relaxations. The relaxations in response to all agonists were significantly decreased in DS on 8% NaCl compared to relaxations in the other rats. Antihypertensive treatment for 8 or 2 weeks prevented or reversed the decreased endothelium-dependent relaxations in response to all agonists tested, but not those to the endothelium-independent agonist, sodium nitroprusside. These results suggest that antihypertensive treatment normalizes endothelium-dependent relaxations. This effect of antihypertensive treatment might be important for the prevention of cardiovascular complications in patients with hypertension. |
Persistent Identifier | http://hdl.handle.net/10722/170854 |
ISSN | 2023 Impact Factor: 6.9 2023 SCImago Journal Rankings: 2.827 |
DC Field | Value | Language |
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dc.contributor.author | Luscher, TF | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.contributor.author | Raij, L | en_US |
dc.date.accessioned | 2012-10-30T06:11:07Z | - |
dc.date.available | 2012-10-30T06:11:07Z | - |
dc.date.issued | 1987 | en_US |
dc.identifier.citation | Hypertension, 1987, v. 9 n. 6 II SUPPL., p. III-193-III-197 | en_US |
dc.identifier.issn | 0194-911X | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170854 | - |
dc.description.abstract | Endothelium-dependent responses are impaired in various models of hypertension. The effects of antihypertensive treatment on endothelium-dependent relaxations were studied in Dahl salt-sensitive (DS) and Dahl salt-resistant rats (DR) on a high or low sodium diet. The rats were given either a diet containing 8% NaCl or 0.1% NaCl for 8 weeks or a diet containing 8% NaCl and a combination of reserpine, hydrochlorothiazide, and hydralazine for 8 or 2 weeks. DS on the 8% NaCl diet developed hypertension, while the other rats did not. Antihypertensive therapy for 8 or 2 weeks prevented or reversed hypertension in DS and lowered blood pressure in DR on the 8% NaCl diet. Aortic rings with and without endothelium were suspended in organ chambers for isometric tension recording. In all groups, acetylcholine, adenosine 5'-diphosphate, and thrombin caused endothelium-dependent relaxations. The relaxations in response to all agonists were significantly decreased in DS on 8% NaCl compared to relaxations in the other rats. Antihypertensive treatment for 8 or 2 weeks prevented or reversed the decreased endothelium-dependent relaxations in response to all agonists tested, but not those to the endothelium-independent agonist, sodium nitroprusside. These results suggest that antihypertensive treatment normalizes endothelium-dependent relaxations. This effect of antihypertensive treatment might be important for the prevention of cardiovascular complications in patients with hypertension. | en_US |
dc.language | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://hyper.ahajournals.org/ | en_US |
dc.relation.ispartof | Hypertension | en_US |
dc.subject | Acetylcholine | - |
dc.subject | Adenosine 5'-diphosphate | - |
dc.subject | Dahl rats | - |
dc.subject | Norepinephrine | - |
dc.subject | Sodium nitroprusside | - |
dc.subject | Thoracic aorta | - |
dc.subject | Thrombin | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Antihypertensive Agents - Pharmacology | en_US |
dc.subject.mesh | Aorta - Physiopathology | en_US |
dc.subject.mesh | Blood Pressure - Drug Effects | en_US |
dc.subject.mesh | Diet, Sodium-Restricted | en_US |
dc.subject.mesh | Drug Resistance | en_US |
dc.subject.mesh | Endothelium - Physiopathology | en_US |
dc.subject.mesh | Hypertension - Chemically Induced - Physiopathology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Nitroprusside - Pharmacology | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Sodium Chloride | en_US |
dc.subject.mesh | Vasoconstriction | en_US |
dc.subject.mesh | Vasodilation - Drug Effects | en_US |
dc.title | Antihypertensive treatment normalizes decreased endothelium-dependent relaxations in rats with salt-induced hypertension | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 3596786 | - |
dc.identifier.scopus | eid_2-s2.0-0023268884 | en_US |
dc.identifier.volume | 9 | en_US |
dc.identifier.issue | 6 II SUPPL. | en_US |
dc.identifier.spage | III | en_US |
dc.identifier.epage | 193 | en_US |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Luscher, TF=18935805600 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.scopusauthorid | Raij, L=7006228846 | en_US |
dc.identifier.issnl | 0194-911X | - |