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- Publisher Website: 10.1159/000138188
- Scopus: eid_2-s2.0-0022469828
- PMID: 3725888
- WOS: WOS:A1986C674900005
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Article: Effects of verapamil, carbenoxolone and N-acetylcysteine on gastric wall mucus and ulceration in stressed rats
Title | Effects of verapamil, carbenoxolone and N-acetylcysteine on gastric wall mucus and ulceration in stressed rats |
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Authors | |
Keywords | Carbenoxolone Gastric mucus Gastric ulcers N-Acetylcysteine Stressed rats Verapamil |
Issue Date | 1986 |
Publisher | S Karger AG. The Journal's web site is located at http://www.karger.com/PHA |
Citation | Pharmacology, 1986, v. 32 n. 6, p. 326-334 How to Cite? |
Abstract | The effects of verapamil on gastric wall mucus and ulceration were studied in rats which were restrained and exposed to 4°C (stress). Stress for 2 h significantly depleted stomach wall mucus and produced marked gastric glandular ulcers. Verapamil pretreatment (2, 4, 8 or 16 mg/kg), injected intraperitoneally 30 min before experimentation, significantly prevented stress-induced mucus depletion and gastric ulceration; however, it did not itself influence stomach wall mucus levels in nonstressed animals. Intragastric administration of carbenoxolone (100 or 200 mg/kg), also given 30 min before stress, exhibited similar actions as verapamil. A 15% solution of N-acetylcysteine (10 ml/kg), given orally, strongly decreased the mucus content in both nonstress and stress conditions; it induced ulcers in nonstressed rats, and worsened stress ulceration. These effects were not reversed by verapamil pretreatment. The influence of multiple-dose pretreatment with verapamil or carbenoxolone on mucus content and ulceration in the gastric glandular mucosa during stress is also discussed. It is concluded that gastric wall mucus depletion is likely to play an important role in stress ulcer formation; the antiulcer action of verapamil could partly be due to the preservation of mucus. |
Persistent Identifier | http://hdl.handle.net/10722/170809 |
ISSN | 2021 Impact Factor: 3.429 2020 SCImago Journal Rankings: 0.510 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Koo, MWL | en_US |
dc.contributor.author | Ogle, CW | en_US |
dc.contributor.author | Cho, CH | en_US |
dc.date.accessioned | 2012-10-30T06:10:57Z | - |
dc.date.available | 2012-10-30T06:10:57Z | - |
dc.date.issued | 1986 | en_US |
dc.identifier.citation | Pharmacology, 1986, v. 32 n. 6, p. 326-334 | en_US |
dc.identifier.issn | 0031-7012 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170809 | - |
dc.description.abstract | The effects of verapamil on gastric wall mucus and ulceration were studied in rats which were restrained and exposed to 4°C (stress). Stress for 2 h significantly depleted stomach wall mucus and produced marked gastric glandular ulcers. Verapamil pretreatment (2, 4, 8 or 16 mg/kg), injected intraperitoneally 30 min before experimentation, significantly prevented stress-induced mucus depletion and gastric ulceration; however, it did not itself influence stomach wall mucus levels in nonstressed animals. Intragastric administration of carbenoxolone (100 or 200 mg/kg), also given 30 min before stress, exhibited similar actions as verapamil. A 15% solution of N-acetylcysteine (10 ml/kg), given orally, strongly decreased the mucus content in both nonstress and stress conditions; it induced ulcers in nonstressed rats, and worsened stress ulceration. These effects were not reversed by verapamil pretreatment. The influence of multiple-dose pretreatment with verapamil or carbenoxolone on mucus content and ulceration in the gastric glandular mucosa during stress is also discussed. It is concluded that gastric wall mucus depletion is likely to play an important role in stress ulcer formation; the antiulcer action of verapamil could partly be due to the preservation of mucus. | en_US |
dc.language | eng | en_US |
dc.publisher | S Karger AG. The Journal's web site is located at http://www.karger.com/PHA | en_US |
dc.relation.ispartof | Pharmacology | en_US |
dc.subject | Carbenoxolone | - |
dc.subject | Gastric mucus | - |
dc.subject | Gastric ulcers | - |
dc.subject | N-Acetylcysteine | - |
dc.subject | Stressed rats | - |
dc.subject | Verapamil | - |
dc.subject.mesh | Acetylcysteine - Administration & Dosage - Pharmacology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Carbenoxolone - Administration & Dosage - Pharmacology | en_US |
dc.subject.mesh | Cold Temperature - Adverse Effects | en_US |
dc.subject.mesh | Drug Administration Schedule | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Gastric Mucosa - Drug Effects | en_US |
dc.subject.mesh | Glycyrrhetinic Acid - Analogs & Derivatives | en_US |
dc.subject.mesh | Mucus - Drug Effects | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Inbred Strains | en_US |
dc.subject.mesh | Restraint, Physical | en_US |
dc.subject.mesh | Stomach Ulcer - Physiopathology - Prevention & Control | en_US |
dc.subject.mesh | Stress, Physiological - Physiopathology | en_US |
dc.subject.mesh | Verapamil - Administration & Dosage - Pharmacology | en_US |
dc.title | Effects of verapamil, carbenoxolone and N-acetylcysteine on gastric wall mucus and ulceration in stressed rats | en_US |
dc.type | Article | en_US |
dc.identifier.email | Koo, MWL:wlkoo@hku.hk | en_US |
dc.identifier.authority | Koo, MWL=rp00233 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1159/000138188 | - |
dc.identifier.pmid | 3725888 | - |
dc.identifier.scopus | eid_2-s2.0-0022469828 | en_US |
dc.identifier.volume | 32 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.spage | 326 | en_US |
dc.identifier.epage | 334 | en_US |
dc.identifier.isi | WOS:A1986C674900005 | - |
dc.publisher.place | Switzerland | en_US |
dc.identifier.scopusauthorid | Koo, MWL=7004550899 | en_US |
dc.identifier.scopusauthorid | Ogle, CW=7103150233 | en_US |
dc.identifier.scopusauthorid | Cho, CH=7403100461 | en_US |
dc.identifier.issnl | 0031-7012 | - |