File Download

There are no files associated with this item.

  Links for fulltext
     (May Require Subscription)
Supplementary

Article: Lipoxygenase and calcium entry in vascular smooth muscle

TitleLipoxygenase and calcium entry in vascular smooth muscle
Authors
Vanhoutte, PMRimele, TJFlavahan, NA
KeywordsCalcium entry
Lipoxygenase
Vascular smooth muscle
Issue Date1985
PublisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/
Citation
Journal Of Cardiovascular Pharmacology, 1985, v. 7 SUPPL. 6, p. S47-S52 How to Cite?
DOI: http://dx.doi.org/10.1097/00005344-198500076-00009
AbstractIn the canine saphenous vein, inhibitors of cyclo-oxygenase augment contractile responses to acetylcholine, potassium chloride and partial α-adrenergic activation. This augmentation is prevented by inhibitors of lipoxygenase, and abolished by calcium entry blockers. These observations suggest that when Ca2+ enters the smooth muscle cells it activates the metabolism of arachidonic acid. If cyclo-oxygenase is inhibited, end-products of lipoxygenase exert a positive feedback on calcium entry. A similar mechanism may explain the hypoxic contractions observed in various blood vessels, including coronary arteries.
Persistent Identifierhttp://hdl.handle.net/10722/170789
ISSN
0160-2446
2023 Impact Factor: 2.6
2023 SCImago Journal Rankings: 0.610
ISI Accession Number ID
WOS:A1985ANY3200009

 

DC FieldValueLanguage
dc.contributor.authorVanhoutte, PMen_US
dc.contributor.authorRimele, TJen_US
dc.contributor.authorFlavahan, NAen_US
dc.date.accessioned2012-10-30T06:10:52Z-
dc.date.available2012-10-30T06:10:52Z-
dc.date.issued1985en_US
dc.identifier.citationJournal Of Cardiovascular Pharmacology, 1985, v. 7 SUPPL. 6, p. S47-S52en_US
dc.identifier.issn0160-2446en_US
dc.identifier.urihttp://hdl.handle.net/10722/170789-
dc.description.abstractIn the canine saphenous vein, inhibitors of cyclo-oxygenase augment contractile responses to acetylcholine, potassium chloride and partial α-adrenergic activation. This augmentation is prevented by inhibitors of lipoxygenase, and abolished by calcium entry blockers. These observations suggest that when Ca2+ enters the smooth muscle cells it activates the metabolism of arachidonic acid. If cyclo-oxygenase is inhibited, end-products of lipoxygenase exert a positive feedback on calcium entry. A similar mechanism may explain the hypoxic contractions observed in various blood vessels, including coronary arteries.en_US
dc.languageengen_US
dc.publisherLippincott Williams & Wilkins. The Journal's web site is located at http://www.cardiovascularpharm.com/en_US
dc.relation.ispartofJournal of Cardiovascular Pharmacologyen_US
dc.subjectCalcium entry-
dc.subjectLipoxygenase-
dc.subjectVascular smooth muscle-
dc.subject.meshAcetylcholine - Pharmacologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshAnoxia - Physiopathologyen_US
dc.subject.meshArachidonic Aciden_US
dc.subject.meshArachidonic Acids - Metabolismen_US
dc.subject.meshCalcium - Physiologyen_US
dc.subject.meshCalcium Channel Blockers - Pharmacologyen_US
dc.subject.meshCatechols - Pharmacologyen_US
dc.subject.meshCyclooxygenase Inhibitorsen_US
dc.subject.meshDogsen_US
dc.subject.meshEpinephrine - Pharmacologyen_US
dc.subject.meshIndomethacin - Pharmacologyen_US
dc.subject.meshLipoxygenase Inhibitorsen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effects - Physiologyen_US
dc.subject.meshNordihydroguaiaretic Aciden_US
dc.subject.meshPotassium - Pharmacologyen_US
dc.titleLipoxygenase and calcium entry in vascular smooth muscleen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1097/00005344-198500076-00009-
dc.identifier.pmid2414595-
dc.identifier.scopuseid_2-s2.0-0022219720en_US
dc.identifier.volume7en_US
dc.identifier.issueSUPPL. 6en_US
dc.identifier.spageS47en_US
dc.identifier.epageS52en_US
dc.identifier.isiWOS:A1985ANY3200009-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.scopusauthoridRimele, TJ=7004614618en_US
dc.identifier.scopusauthoridFlavahan, NA=7006398882en_US
dc.identifier.issnl0160-2446-

Export via OAI-PMH Interface in XML Formats

OR

Export to Other Non-XML Formats