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- Publisher Website: 10.1016/0014-2999(85)90238-9
- Scopus: eid_2-s2.0-0021838162
- PMID: 4018138
- WOS: WOS:A1985ALG4500007
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Article: Electrophysiological actions of flecainide in normal and infarcted canine purkinje fibers
Title | Electrophysiological actions of flecainide in normal and infarcted canine purkinje fibers |
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Authors | |
Keywords | Electrophysiological effects Flecainide Normal Purkinje fibers Purkinje fibers surviving infarction |
Issue Date | 1985 |
Publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar |
Citation | European Journal Of Pharmacology, 1985, v. 112 n. 1, p. 57-64 How to Cite? |
Abstract | The electrophsiological effects of flecainide, 0.1, 0.5 and 1.0 mg/l, on action potential characteristics were examined in normal Purkinje fibers and Purkinje fibers surviving infarction, at stimulation cycle lengths of 1000 and 300 ms. Overshoot, amplitude and dV/dt(max) were reduced significantly in a dose-dependent manner by flecainide in both normal Purkinje fibers and Purkinje fibers surviving infarction. Action potential duration was shortened by flecainide to a greater extent: at the cycle length of 1000 ms compared to 300 ms; at 50% repolarization compared to 90%; and in normal preparations compared to infarcted preparations. Activation time was increased by flecainide in a dose-dependent manner in both types of preparations. This effect was enhanced at the shorter cycle length. In both normal and infarcted preparations, flecainide shortened the ERP of those having a longer initial ERP and lengthened those with a shorter ERP. This effect was significant only at the stimulation cycle length of 1000 ms. This study indicates that flecainide has properties unique and different from traditional antiarrhythmic drugs. |
Persistent Identifier | http://hdl.handle.net/10722/170768 |
ISSN | 2023 Impact Factor: 4.2 2023 SCImago Journal Rankings: 1.055 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Kinnaird, AAA | en_US |
dc.contributor.author | Lederman, CL | en_US |
dc.contributor.author | Man, RYK | en_US |
dc.date.accessioned | 2012-10-30T06:10:46Z | - |
dc.date.available | 2012-10-30T06:10:46Z | - |
dc.date.issued | 1985 | en_US |
dc.identifier.citation | European Journal Of Pharmacology, 1985, v. 112 n. 1, p. 57-64 | en_US |
dc.identifier.issn | 0014-2999 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170768 | - |
dc.description.abstract | The electrophsiological effects of flecainide, 0.1, 0.5 and 1.0 mg/l, on action potential characteristics were examined in normal Purkinje fibers and Purkinje fibers surviving infarction, at stimulation cycle lengths of 1000 and 300 ms. Overshoot, amplitude and dV/dt(max) were reduced significantly in a dose-dependent manner by flecainide in both normal Purkinje fibers and Purkinje fibers surviving infarction. Action potential duration was shortened by flecainide to a greater extent: at the cycle length of 1000 ms compared to 300 ms; at 50% repolarization compared to 90%; and in normal preparations compared to infarcted preparations. Activation time was increased by flecainide in a dose-dependent manner in both types of preparations. This effect was enhanced at the shorter cycle length. In both normal and infarcted preparations, flecainide shortened the ERP of those having a longer initial ERP and lengthened those with a shorter ERP. This effect was significant only at the stimulation cycle length of 1000 ms. This study indicates that flecainide has properties unique and different from traditional antiarrhythmic drugs. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar | en_US |
dc.relation.ispartof | European Journal of Pharmacology | en_US |
dc.subject | Electrophysiological effects | - |
dc.subject | Flecainide | - |
dc.subject | Normal Purkinje fibers | - |
dc.subject | Purkinje fibers surviving infarction | - |
dc.subject.mesh | Action Potentials - Drug Effects | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Electrophysiology | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Flecainide | en_US |
dc.subject.mesh | Heart Conduction System - Drug Effects | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Microelectrodes | en_US |
dc.subject.mesh | Myocardial Infarction - Physiopathology | en_US |
dc.subject.mesh | Piperidines - Pharmacology | en_US |
dc.subject.mesh | Purkinje Fibers - Drug Effects | en_US |
dc.title | Electrophysiological actions of flecainide in normal and infarcted canine purkinje fibers | en_US |
dc.type | Article | en_US |
dc.identifier.email | Man, RYK:rykman@hkucc.hku.hk | en_US |
dc.identifier.authority | Man, RYK=rp00236 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/0014-2999(85)90238-9 | en_US |
dc.identifier.pmid | 4018138 | - |
dc.identifier.scopus | eid_2-s2.0-0021838162 | en_US |
dc.identifier.volume | 112 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 57 | en_US |
dc.identifier.epage | 64 | en_US |
dc.identifier.isi | WOS:A1985ALG4500007 | - |
dc.publisher.place | Netherlands | en_US |
dc.identifier.scopusauthorid | Kinnaird, AAA=6603472891 | en_US |
dc.identifier.scopusauthorid | Lederman, CL=6701809777 | en_US |
dc.identifier.scopusauthorid | Man, RYK=7004986435 | en_US |
dc.identifier.issnl | 0014-2999 | - |