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- Publisher Website: 10.1161/01.STR.16.4.718
- Scopus: eid_2-s2.0-0021796057
- PMID: 4024184
- WOS: WOS:A1985ANH1700027
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Article: 5-Hydroxytryptamine: Source of activator calcium in human basilar arteries
Title | 5-Hydroxytryptamine: Source of activator calcium in human basilar arteries |
---|---|
Authors | |
Issue Date | 1985 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://stroke.ahajournals.org |
Citation | Stroke, 1985, v. 16 n. 4, p. 718-720 How to Cite? |
Abstract | We performed experiments in human cerebral arteries to determine the source of activator calcium during contractions induced by 5-hydroxytryptamine. Rings of human basilar artery obtained at autopsy were mounted for isometric tension recording in organ baths filled with a physiological salt solution. Contractile responses to 5-hydroxytryptamine were virtually abolished in Ca ++-free solution, and inhibited significantly by nimodipine. In both cases, the depression of the response to 5-hydroxytryptamine was comparable to that seen when KCl was used to contract the vessels. These experiments demonstrate that 5-hydroxytryptamine mediates contraction of the smooth muscle in human basilar artery by increasing membrane permeability to extracellular calcium. |
Persistent Identifier | http://hdl.handle.net/10722/170760 |
ISSN | 2021 Impact Factor: 10.170 2020 SCImago Journal Rankings: 3.397 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Rusch, NJ | en_US |
dc.contributor.author | Chyatte, D | en_US |
dc.contributor.author | Sundt Jr, TM | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:10:44Z | - |
dc.date.available | 2012-10-30T06:10:44Z | - |
dc.date.issued | 1985 | en_US |
dc.identifier.citation | Stroke, 1985, v. 16 n. 4, p. 718-720 | en_US |
dc.identifier.issn | 0039-2499 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170760 | - |
dc.description.abstract | We performed experiments in human cerebral arteries to determine the source of activator calcium during contractions induced by 5-hydroxytryptamine. Rings of human basilar artery obtained at autopsy were mounted for isometric tension recording in organ baths filled with a physiological salt solution. Contractile responses to 5-hydroxytryptamine were virtually abolished in Ca ++-free solution, and inhibited significantly by nimodipine. In both cases, the depression of the response to 5-hydroxytryptamine was comparable to that seen when KCl was used to contract the vessels. These experiments demonstrate that 5-hydroxytryptamine mediates contraction of the smooth muscle in human basilar artery by increasing membrane permeability to extracellular calcium. | en_US |
dc.language | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://stroke.ahajournals.org | en_US |
dc.relation.ispartof | Stroke | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Basilar Artery - Drug Effects | en_US |
dc.subject.mesh | Calcium - Pharmacology | en_US |
dc.subject.mesh | Calcium Channel Blockers - Pharmacology | en_US |
dc.subject.mesh | Capillary Permeability - Drug Effects | en_US |
dc.subject.mesh | Cerebral Arteries - Drug Effects | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Muscle Contraction - Drug Effects | en_US |
dc.subject.mesh | Muscle, Smooth, Vascular - Drug Effects | en_US |
dc.subject.mesh | Nicotinic Acids - Pharmacology | en_US |
dc.subject.mesh | Nimodipine | en_US |
dc.subject.mesh | Serotonin - Pharmacology | en_US |
dc.title | 5-Hydroxytryptamine: Source of activator calcium in human basilar arteries | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1161/01.STR.16.4.718 | - |
dc.identifier.pmid | 4024184 | - |
dc.identifier.scopus | eid_2-s2.0-0021796057 | en_US |
dc.identifier.volume | 16 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.spage | 718 | en_US |
dc.identifier.epage | 720 | en_US |
dc.identifier.isi | WOS:A1985ANH1700027 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Rusch, NJ=7005728816 | en_US |
dc.identifier.scopusauthorid | Chyatte, D=7003587726 | en_US |
dc.identifier.scopusauthorid | Sundt Jr, TM=34572694400 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0039-2499 | - |