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- Publisher Website: 10.1172/JCI111499
- Scopus: eid_2-s2.0-0021174628
- PMID: 6470141
- WOS: WOS:A1984TJ05800018
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Article: Aggregating platelets contract isolated canine pulmonary arteries by releasing 5-hydroxytryptamine
Title | Aggregating platelets contract isolated canine pulmonary arteries by releasing 5-hydroxytryptamine |
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Authors | |
Issue Date | 1984 |
Publisher | American Society for Clinical Investigation. The Journal's web site is located at http://www.jci.org |
Citation | Journal Of Clinical Investigation, 1984, v. 74 n. 3, p. 828-833 How to Cite? |
Abstract | To examine the effect of platelets and 5-hydroxytryptamine on pulmonary arterial smooth muscle, rings of canine pulmonary arteries, with and without endothelium, were studied under isometric conditions in physiological salt solution. 5-Hydroxytryptamine, but not the thromboxane-like endoperoxide analogue U-46619, produced concentration-dependent contractions of the rings with a maximum averaging 93% of that obtained with KCl. Autologous platelets in concentrations comparable to that in plasma caused contractions averaging 70% of the maximal responses to KCl. Solution withdrawn from baths containing platelet-contracted rings, but not the supernatant from nonaggregated platelets, also caused contraction. The serotonergic antagonists cyproheptadine, ketanserin, and methysergide caused concentration-dependent inhibition and eventually abolition of contractions evoked by platelets and 5-hydroxytryptamine. Phentolamine and prazosin produced significantly less inhibition of the contractile response to platelets. Pretreatment of the platelets with indomethacin or meclofenamate reduced thromboxane release but had no effect on platelet-induced contractions. Removal of the endothelium did not affect contractile responses to platelets or 5-hydroxytryptamine. These experiments demonstrate that in the canine pulmonary artery: (a) 5-hydroxytryptamine is the predominant mediator of the contractile response triggered by platelet aggregation; and (b) unlike in other blood vessels, the endothelium cannot curtail the contractile response to aggregating platelets. |
Persistent Identifier | http://hdl.handle.net/10722/170729 |
ISSN | 2023 Impact Factor: 13.3 2023 SCImago Journal Rankings: 4.833 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Mcgoon, MD | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:10:37Z | - |
dc.date.available | 2012-10-30T06:10:37Z | - |
dc.date.issued | 1984 | en_US |
dc.identifier.citation | Journal Of Clinical Investigation, 1984, v. 74 n. 3, p. 828-833 | en_US |
dc.identifier.issn | 0021-9738 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170729 | - |
dc.description.abstract | To examine the effect of platelets and 5-hydroxytryptamine on pulmonary arterial smooth muscle, rings of canine pulmonary arteries, with and without endothelium, were studied under isometric conditions in physiological salt solution. 5-Hydroxytryptamine, but not the thromboxane-like endoperoxide analogue U-46619, produced concentration-dependent contractions of the rings with a maximum averaging 93% of that obtained with KCl. Autologous platelets in concentrations comparable to that in plasma caused contractions averaging 70% of the maximal responses to KCl. Solution withdrawn from baths containing platelet-contracted rings, but not the supernatant from nonaggregated platelets, also caused contraction. The serotonergic antagonists cyproheptadine, ketanserin, and methysergide caused concentration-dependent inhibition and eventually abolition of contractions evoked by platelets and 5-hydroxytryptamine. Phentolamine and prazosin produced significantly less inhibition of the contractile response to platelets. Pretreatment of the platelets with indomethacin or meclofenamate reduced thromboxane release but had no effect on platelet-induced contractions. Removal of the endothelium did not affect contractile responses to platelets or 5-hydroxytryptamine. These experiments demonstrate that in the canine pulmonary artery: (a) 5-hydroxytryptamine is the predominant mediator of the contractile response triggered by platelet aggregation; and (b) unlike in other blood vessels, the endothelium cannot curtail the contractile response to aggregating platelets. | en_US |
dc.language | eng | en_US |
dc.publisher | American Society for Clinical Investigation. The Journal's web site is located at http://www.jci.org | en_US |
dc.relation.ispartof | Journal of Clinical Investigation | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Blood Platelets - Physiology | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Epinephrine - Metabolism | en_US |
dc.subject.mesh | Ketanserin | en_US |
dc.subject.mesh | Muscle Contraction | en_US |
dc.subject.mesh | Norepinephrine - Metabolism | en_US |
dc.subject.mesh | Piperidines - Pharmacology | en_US |
dc.subject.mesh | Platelet Aggregation | en_US |
dc.subject.mesh | Pulmonary Artery - Drug Effects - Physiology | en_US |
dc.subject.mesh | Serotonin - Blood - Metabolism - Secretion | en_US |
dc.subject.mesh | Serotonin Antagonists - Pharmacology | en_US |
dc.subject.mesh | Thromboxane B2 - Blood | en_US |
dc.title | Aggregating platelets contract isolated canine pulmonary arteries by releasing 5-hydroxytryptamine | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1172/JCI111499 | - |
dc.identifier.pmid | 6470141 | - |
dc.identifier.scopus | eid_2-s2.0-0021174628 | en_US |
dc.identifier.volume | 74 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 828 | en_US |
dc.identifier.epage | 833 | en_US |
dc.identifier.isi | WOS:A1984TJ05800018 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | McGoon, MD=7004310801 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0021-9738 | - |