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Article: Selectivity of calcium antagonism and serotonin antagonism with respect to venous and arterial tissues

TitleSelectivity of calcium antagonism and serotonin antagonism with respect to venous and arterial tissues
Authors
Van Nueten, JMVanhoutte, PM
Issue Date1981
PublisherSage Publications, Inc. The Journal's web site is located at http://ang.sagepub.com
Citation
Angiology, 1981, v. 32 n. 7, p. 476-484 How to Cite?
DOI: http://dx.doi.org/10.1177/000331978103200704
AbstractDifferences of arterial and venous smooth muscle tissues in their sensitivity to Ca2+ antagonists and to serotonin antagonists were studied in a number of blood vessels. The tissue selectivity for Ca2+ antagonists, in particular differences between arteries and veins is related both to the presence of extra- and intracellular pools from which Ca2+ ions are mobilized and to differences in access to or sensitivity of the Ca2+ channels in various vascular tissues. Tissue selectivity also exists for serotonin as well as for serotonin antagonists of which R 41 468 is an example of a compound with high selectivity for vascular tissues.
Persistent Identifierhttp://hdl.handle.net/10722/170654
ISSN
0003-3197
2023 Impact Factor: 2.6
2023 SCImago Journal Rankings: 0.695
ISI Accession Number ID
WOS:A1981LY48200004

 

DC FieldValueLanguage
dc.contributor.authorVan Nueten, JMen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:18Z-
dc.date.available2012-10-30T06:10:18Z-
dc.date.issued1981en_US
dc.identifier.citationAngiology, 1981, v. 32 n. 7, p. 476-484en_US
dc.identifier.issn0003-3197en_US
dc.identifier.urihttp://hdl.handle.net/10722/170654-
dc.description.abstractDifferences of arterial and venous smooth muscle tissues in their sensitivity to Ca2+ antagonists and to serotonin antagonists were studied in a number of blood vessels. The tissue selectivity for Ca2+ antagonists, in particular differences between arteries and veins is related both to the presence of extra- and intracellular pools from which Ca2+ ions are mobilized and to differences in access to or sensitivity of the Ca2+ channels in various vascular tissues. Tissue selectivity also exists for serotonin as well as for serotonin antagonists of which R 41 468 is an example of a compound with high selectivity for vascular tissues.en_US
dc.languageengen_US
dc.publisherSage Publications, Inc. The Journal's web site is located at http://ang.sagepub.comen_US
dc.relation.ispartofAngiologyen_US
dc.subject.meshAnimalsen_US
dc.subject.meshArteries - Drug Effectsen_US
dc.subject.meshCalcium - Antagonists & Inhibitorsen_US
dc.subject.meshCinnarizine - Analogs & Derivatives - Pharmacologyen_US
dc.subject.meshDogsen_US
dc.subject.meshFlunarizineen_US
dc.subject.meshKetanserinen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effectsen_US
dc.subject.meshPiperidines - Pharmacologyen_US
dc.subject.meshRabbitsen_US
dc.subject.meshRatsen_US
dc.subject.meshSerotonin - Pharmacologyen_US
dc.subject.meshSerotonin Antagonists - Pharmacologyen_US
dc.subject.meshVeins - Drug Effectsen_US
dc.titleSelectivity of calcium antagonism and serotonin antagonism with respect to venous and arterial tissuesen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1177/000331978103200704-
dc.identifier.pmid7247071-
dc.identifier.scopuseid_2-s2.0-0019798984en_US
dc.identifier.volume32en_US
dc.identifier.issue7en_US
dc.identifier.spage476en_US
dc.identifier.epage484en_US
dc.identifier.isiWOS:A1981LY48200004-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridVan Nueten, JM=7005700327en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.issnl0003-3197-

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