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Article: Effect of the Ca2+ antagonist lidoflazine on normoxic and anoxic contractions of canine coronary arterial smooth muscle

TitleEffect of the Ca2+ antagonist lidoflazine on normoxic and anoxic contractions of canine coronary arterial smooth muscle
Authors
Van Nueten, JMVanhoutte, PM
Keywords5-Hydroxytryptamine
Anoxic constriction
Ca2+ antagonism
Coronary vasospasm
Lidoflazine
Norepinephrine
Issue Date1980
PublisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejphar
Citation
European Journal Of Pharmacology, 1980, v. 64 n. 2-3, p. 173-176 How to Cite?
DOI: http://dx.doi.org/10.1016/0014-2999(80)90042-4
AbstractAnoxia augments contractions of isolated canine coronary arteries to 5-hydroxytryptamine and norepinephrine. Lidoflazine inhibits normoxic contractions to both monoamines and the further increases in tension seen with anoxia in rings exposed to 5-hydroxytryptamine; further increases in tension caused by anoxia in presence of norepinephrine were not affected by lidoflazine. These experiments demonstrate that anoxia can cause constriction of large coronary arteries and that lidoflazine depresses both anoxic and normoxic contractions of coronary smooth muscle.
Persistent Identifierhttp://hdl.handle.net/10722/170605
ISSN
0014-2999
2023 Impact Factor: 4.2
2023 SCImago Journal Rankings: 1.055
ISI Accession Number ID
WOS:A1980KB39100011

 

DC FieldValueLanguage
dc.contributor.authorVan Nueten, JMen_US
dc.contributor.authorVanhoutte, PMen_US
dc.date.accessioned2012-10-30T06:10:07Z-
dc.date.available2012-10-30T06:10:07Z-
dc.date.issued1980en_US
dc.identifier.citationEuropean Journal Of Pharmacology, 1980, v. 64 n. 2-3, p. 173-176en_US
dc.identifier.issn0014-2999en_US
dc.identifier.urihttp://hdl.handle.net/10722/170605-
dc.description.abstractAnoxia augments contractions of isolated canine coronary arteries to 5-hydroxytryptamine and norepinephrine. Lidoflazine inhibits normoxic contractions to both monoamines and the further increases in tension seen with anoxia in rings exposed to 5-hydroxytryptamine; further increases in tension caused by anoxia in presence of norepinephrine were not affected by lidoflazine. These experiments demonstrate that anoxia can cause constriction of large coronary arteries and that lidoflazine depresses both anoxic and normoxic contractions of coronary smooth muscle.en_US
dc.languageengen_US
dc.publisherElsevier BV. The Journal's web site is located at http://www.elsevier.com/locate/ejpharen_US
dc.relation.ispartofEuropean Journal of Pharmacologyen_US
dc.subject5-Hydroxytryptamine-
dc.subjectAnoxic constriction-
dc.subjectCa2+ antagonism-
dc.subjectCoronary vasospasm-
dc.subjectLidoflazine-
dc.subjectNorepinephrine-
dc.subject.meshAnimalsen_US
dc.subject.meshCalcium - Antagonists & Inhibitors - Metabolismen_US
dc.subject.meshCoronary Vessels - Drug Effectsen_US
dc.subject.meshDogsen_US
dc.subject.meshDose-Response Relationship, Drugen_US
dc.subject.meshLidoflazine - Pharmacologyen_US
dc.subject.meshMuscle Contraction - Drug Effectsen_US
dc.subject.meshMuscle, Smooth, Vascular - Drug Effectsen_US
dc.subject.meshNorepinephrine - Pharmacologyen_US
dc.subject.meshOxygenen_US
dc.subject.meshPiperazines - Pharmacologyen_US
dc.subject.meshSerotonin - Pharmacologyen_US
dc.titleEffect of the Ca2+ antagonist lidoflazine on normoxic and anoxic contractions of canine coronary arterial smooth muscleen_US
dc.typeArticleen_US
dc.identifier.emailVanhoutte, PM:vanhoutt@hku.hken_US
dc.identifier.authorityVanhoutte, PM=rp00238en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1016/0014-2999(80)90042-4-
dc.identifier.pmid7398761-
dc.identifier.scopuseid_2-s2.0-0018910233en_US
dc.identifier.volume64en_US
dc.identifier.issue2-3en_US
dc.identifier.spage173en_US
dc.identifier.epage176en_US
dc.identifier.isiWOS:A1980KB39100011-
dc.publisher.placeNetherlandsen_US
dc.identifier.scopusauthoridVan Nueten, JM=7005700327en_US
dc.identifier.scopusauthoridVanhoutte, PM=7202304247en_US
dc.identifier.issnl0014-2999-

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