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- Scopus: eid_2-s2.0-0018757797
- PMID: 221058
- WOS: WOS:A1979HB03700001
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Article: Interaction between neuronal amine uptake and prejunctional alpha-adrenergic receptor activation in smooth muscle from canine blood vessels and spleen
Title | Interaction between neuronal amine uptake and prejunctional alpha-adrenergic receptor activation in smooth muscle from canine blood vessels and spleen |
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Authors | |
Issue Date | 1979 |
Publisher | S Karger AG. The Journal's web site is located at http://www.karger.com/JVR |
Citation | Blood Vessels, 1979, v. 16 n. 3, p. 113-125 How to Cite? |
Abstract | Experiments were performed to determine the conditions in which norepinephrine release from adrenergic nerve terminals in smooth muscle from canine blood vessels and spleen might be inhibited by prejunctional α-adrenergic receptor activation. Strips of aorta, mesenteric and splenic arteries, splenic capsule and portal and saphenous veins were labeled with 7-3H-norepinephrine and mounted for superfusion. In the portal vein, an inhibitory effect of prejunctional receptor activation with exogenous norepinephrine (1.2 x 10-6M) on transmitter efflux could be demonstrated during electrical stimulation (9 V, 2 Hz) of the nerve terminals. By contrast, in the other tissues, inhibition of transmitter release during electrical stimulation or depolarization of the nerve terminals with K+ (40 mEq/1) could only be demonstrated after blockade of the neuronal uptake mechanism. That activation of prejunctional α-adrenergic receptors in blood vessels inhibits the exocytotic process is suggested by the failure of exogenous norepinephrine to affect either the basal efflux of 3H-norepinephrine or the displacement of 3H-norepinephrine by tyramine. |
Persistent Identifier | http://hdl.handle.net/10722/170596 |
ISSN | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Lorenz, RR | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.contributor.author | Shepherd, JT | en_US |
dc.date.accessioned | 2012-10-30T06:10:05Z | - |
dc.date.available | 2012-10-30T06:10:05Z | - |
dc.date.issued | 1979 | en_US |
dc.identifier.citation | Blood Vessels, 1979, v. 16 n. 3, p. 113-125 | en_US |
dc.identifier.issn | 0303-6847 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170596 | - |
dc.description.abstract | Experiments were performed to determine the conditions in which norepinephrine release from adrenergic nerve terminals in smooth muscle from canine blood vessels and spleen might be inhibited by prejunctional α-adrenergic receptor activation. Strips of aorta, mesenteric and splenic arteries, splenic capsule and portal and saphenous veins were labeled with 7-3H-norepinephrine and mounted for superfusion. In the portal vein, an inhibitory effect of prejunctional receptor activation with exogenous norepinephrine (1.2 x 10-6M) on transmitter efflux could be demonstrated during electrical stimulation (9 V, 2 Hz) of the nerve terminals. By contrast, in the other tissues, inhibition of transmitter release during electrical stimulation or depolarization of the nerve terminals with K+ (40 mEq/1) could only be demonstrated after blockade of the neuronal uptake mechanism. That activation of prejunctional α-adrenergic receptors in blood vessels inhibits the exocytotic process is suggested by the failure of exogenous norepinephrine to affect either the basal efflux of 3H-norepinephrine or the displacement of 3H-norepinephrine by tyramine. | en_US |
dc.language | eng | en_US |
dc.publisher | S Karger AG. The Journal's web site is located at http://www.karger.com/JVR | en_US |
dc.relation.ispartof | Blood Vessels | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Aorta, Abdominal - Innervation | en_US |
dc.subject.mesh | Blood Vessels - Drug Effects - Innervation - Metabolism | en_US |
dc.subject.mesh | Chromatography | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Electric Stimulation | en_US |
dc.subject.mesh | Mesenteric Arteries - Innervation | en_US |
dc.subject.mesh | Muscle Contraction - Drug Effects | en_US |
dc.subject.mesh | Muscle, Smooth - Drug Effects - Innervation - Metabolism | en_US |
dc.subject.mesh | Neuromuscular Junction - Drug Effects | en_US |
dc.subject.mesh | Neurons - Metabolism | en_US |
dc.subject.mesh | Norepinephrine - Metabolism - Pharmacology | en_US |
dc.subject.mesh | Phenoxybenzamine - Pharmacology | en_US |
dc.subject.mesh | Receptors, Adrenergic - Drug Effects | en_US |
dc.subject.mesh | Receptors, Adrenergic, Alpha - Drug Effects | en_US |
dc.subject.mesh | Saphenous Vein - Innervation | en_US |
dc.subject.mesh | Splenic Artery - Innervation | en_US |
dc.subject.mesh | Synaptic Transmission - Drug Effects | en_US |
dc.title | Interaction between neuronal amine uptake and prejunctional alpha-adrenergic receptor activation in smooth muscle from canine blood vessels and spleen | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 221058 | - |
dc.identifier.scopus | eid_2-s2.0-0018757797 | en_US |
dc.identifier.volume | 16 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 113 | en_US |
dc.identifier.epage | 125 | en_US |
dc.identifier.isi | WOS:A1979HB03700001 | - |
dc.publisher.place | Switzerland | en_US |
dc.identifier.scopusauthorid | Lorenz, RR=7402095192 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.scopusauthorid | Shepherd, JT=7401742522 | en_US |
dc.identifier.issnl | 0303-6847 | - |