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- Scopus: eid_2-s2.0-0017349998
- PMID: 850138
- WOS: WOS:A1977DE30100021
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Article: Effect of lidocaine and methyl lidocaine on cardiac conduction
Title | Effect of lidocaine and methyl lidocaine on cardiac conduction |
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Authors | |
Issue Date | 1977 |
Publisher | American Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://jpet.aspetjournals.org |
Citation | Journal Of Pharmacology And Experimental Therapeutics, 1977, v. 201 n. 1, p. 184-191 How to Cite? |
Abstract | The effects of lidocaine and methyl lidocaine on cardiac conduction were studied using His bundle recordings from isolated blood perfused dog hearts. The input and output characteristic of the atrioventricular (AV) node can be described as consisting of three components, namely, minimal conduction time, fatigue, and the effect of prematurity (ΔCT). Lidocaine (2.5-10.0 mg/kg) increased minimal conduction time but not fatigue. Methyl lidocaine (1.25-5.0 mg/kg) increased both. A dose of 5 mg/kg or less of either drug caused a nonparallel shift of the ΔCT curve to the right. High doses of lidocaine (10 mg/kg) cause ΔCT to become rate-dependent. Lidocaine slowed atrial conduction only slightly. Atrial block prevented the observation of the effect of methyl lidocaine in doses higher than 5.0 mg/kg. Both drugs showed greater effect on atrial conduction at fast heart rate. Lidocaine did not affect ventricular conduction time at slow heart rates and had only minimal effects at fast heart rates. Methyl lidocaine increased ventricular conduction time at all heart rates. The results of this study indicate that lidocaine and methyl lidocaine have entirely different spectra of activity on cardiac conduction, in that their effects on AV nodal conduction do not differ greatly whereas the quaternary analog has a much stronger depressant effect on atrial and ventricular conduction. |
Persistent Identifier | http://hdl.handle.net/10722/170526 |
ISSN | 2023 Impact Factor: 3.1 2023 SCImago Journal Rankings: 0.829 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Man, RYK | en_US |
dc.contributor.author | Dresel, PE | en_US |
dc.date.accessioned | 2012-10-30T06:09:49Z | - |
dc.date.available | 2012-10-30T06:09:49Z | - |
dc.date.issued | 1977 | en_US |
dc.identifier.citation | Journal Of Pharmacology And Experimental Therapeutics, 1977, v. 201 n. 1, p. 184-191 | en_US |
dc.identifier.issn | 0022-3565 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170526 | - |
dc.description.abstract | The effects of lidocaine and methyl lidocaine on cardiac conduction were studied using His bundle recordings from isolated blood perfused dog hearts. The input and output characteristic of the atrioventricular (AV) node can be described as consisting of three components, namely, minimal conduction time, fatigue, and the effect of prematurity (ΔCT). Lidocaine (2.5-10.0 mg/kg) increased minimal conduction time but not fatigue. Methyl lidocaine (1.25-5.0 mg/kg) increased both. A dose of 5 mg/kg or less of either drug caused a nonparallel shift of the ΔCT curve to the right. High doses of lidocaine (10 mg/kg) cause ΔCT to become rate-dependent. Lidocaine slowed atrial conduction only slightly. Atrial block prevented the observation of the effect of methyl lidocaine in doses higher than 5.0 mg/kg. Both drugs showed greater effect on atrial conduction at fast heart rate. Lidocaine did not affect ventricular conduction time at slow heart rates and had only minimal effects at fast heart rates. Methyl lidocaine increased ventricular conduction time at all heart rates. The results of this study indicate that lidocaine and methyl lidocaine have entirely different spectra of activity on cardiac conduction, in that their effects on AV nodal conduction do not differ greatly whereas the quaternary analog has a much stronger depressant effect on atrial and ventricular conduction. | en_US |
dc.language | eng | en_US |
dc.publisher | American Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://jpet.aspetjournals.org | en_US |
dc.relation.ispartof | Journal of Pharmacology and Experimental Therapeutics | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Atrioventricular Node - Drug Effects - Physiology | en_US |
dc.subject.mesh | Bundle Of His | en_US |
dc.subject.mesh | Depression, Chemical | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Electric Stimulation | en_US |
dc.subject.mesh | Electrocardiography | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Heart Conduction System - Drug Effects - Physiology | en_US |
dc.subject.mesh | Heart Rate | en_US |
dc.subject.mesh | Lidocaine - Analogs & Derivatives - Pharmacology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Refractory Period, Electrophysiological - Drug Effects | en_US |
dc.subject.mesh | Time Factors | en_US |
dc.title | Effect of lidocaine and methyl lidocaine on cardiac conduction | en_US |
dc.type | Article | en_US |
dc.identifier.email | Man, RYK:rykman@hkucc.hku.hk | en_US |
dc.identifier.authority | Man, RYK=rp00236 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 850138 | - |
dc.identifier.scopus | eid_2-s2.0-0017349998 | en_US |
dc.identifier.volume | 201 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 184 | en_US |
dc.identifier.epage | 191 | en_US |
dc.identifier.isi | WOS:A1977DE30100021 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Man, RYK=7004986435 | en_US |
dc.identifier.scopusauthorid | Dresel, PE=7004058750 | en_US |
dc.identifier.issnl | 0022-3565 | - |