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- Publisher Website: 10.1093/bja/49.3.211
- Scopus: eid_2-s2.0-0017348884
- PMID: 20911
- WOS: WOS:A1977CY91600004
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Article: Alpha adrenergic blocking properties of droperidol on isolated blood vessels of the dog
Title | Alpha adrenergic blocking properties of droperidol on isolated blood vessels of the dog |
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Authors | |
Issue Date | 1977 |
Publisher | Oxford University Press. The Journal's web site is located at http://bja.oxfordjournals.org/ |
Citation | British Journal Of Anaesthesia, 1977, v. 49 n. 3, p. 211-216 How to Cite? |
Abstract | Concentrations of droperidol which caused a shift to the right of the dose response curve to noradrenaline in the pulmonary artery and the saphenous vein of the dog did not affect myogenic activation by K +; they did not inhibit spontaneous activity of portal mesenteric veins. Droperidol inhibited the contractile response to nerve stimulation, but did not effect the evoked release of 3H noradrenaline. These experiments indicate that the vasodilator properties of smaller doses of droperidol are a result of its ability to block alpha adrenergic receptors. |
Persistent Identifier | http://hdl.handle.net/10722/170525 |
ISSN | 2023 Impact Factor: 9.1 2023 SCImago Journal Rankings: 2.397 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Muldoon, SM | en_US |
dc.contributor.author | Janssens, WJ | en_US |
dc.contributor.author | Verbeuren, TJ | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:09:48Z | - |
dc.date.available | 2012-10-30T06:09:48Z | - |
dc.date.issued | 1977 | en_US |
dc.identifier.citation | British Journal Of Anaesthesia, 1977, v. 49 n. 3, p. 211-216 | en_US |
dc.identifier.issn | 0007-0912 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170525 | - |
dc.description.abstract | Concentrations of droperidol which caused a shift to the right of the dose response curve to noradrenaline in the pulmonary artery and the saphenous vein of the dog did not affect myogenic activation by K +; they did not inhibit spontaneous activity of portal mesenteric veins. Droperidol inhibited the contractile response to nerve stimulation, but did not effect the evoked release of 3H noradrenaline. These experiments indicate that the vasodilator properties of smaller doses of droperidol are a result of its ability to block alpha adrenergic receptors. | en_US |
dc.language | eng | en_US |
dc.publisher | Oxford University Press. The Journal's web site is located at http://bja.oxfordjournals.org/ | en_US |
dc.relation.ispartof | British Journal of Anaesthesia | en_US |
dc.subject.mesh | Adrenergic Alpha-Antagonists | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Blood Vessels - Drug Effects | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Dose-Response Relationship, Drug | en_US |
dc.subject.mesh | Droperidol - Pharmacology | en_US |
dc.subject.mesh | Electric Stimulation | en_US |
dc.subject.mesh | Mesenteric Veins - Drug Effects | en_US |
dc.subject.mesh | Muscle, Smooth - Drug Effects | en_US |
dc.subject.mesh | Norepinephrine - Antagonists & Inhibitors | en_US |
dc.subject.mesh | Potassium - Pharmacology | en_US |
dc.subject.mesh | Pulmonary Artery - Drug Effects | en_US |
dc.subject.mesh | Saphenous Vein - Drug Effects | en_US |
dc.title | Alpha adrenergic blocking properties of droperidol on isolated blood vessels of the dog | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1093/bja/49.3.211 | - |
dc.identifier.pmid | 20911 | - |
dc.identifier.scopus | eid_2-s2.0-0017348884 | en_US |
dc.identifier.volume | 49 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 211 | en_US |
dc.identifier.epage | 216 | en_US |
dc.identifier.isi | WOS:A1977CY91600004 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Muldoon, SM=7006041150 | en_US |
dc.identifier.scopusauthorid | Janssens, WJ=7006876881 | en_US |
dc.identifier.scopusauthorid | Verbeuren, TJ=7007006534 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0007-0912 | - |