File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Scopus: eid_2-s2.0-0017249672
- PMID: 177755
- WOS: WOS:A1976BM51100021
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Effects of amide linked local anesthetics on adrenergic neuroeffector junction in cutaneous veins of dog
Title | Effects of amide linked local anesthetics on adrenergic neuroeffector junction in cutaneous veins of dog |
---|---|
Authors | |
Issue Date | 1976 |
Publisher | American Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://jpet.aspetjournals.org |
Citation | Journal Of Pharmacology And Experimental Therapeutics, 1976, v. 196 n. 3, p. 723-736 How to Cite? |
Abstract | When changes in isometric tension of helical strips of dog saphenous veins were recorded, etidocaine caused a dose dependent depression of the contractile responses to nerve stimulation, norepinephrine and K+. The response to nerve stimulation was significantly more depressed than that to exogenous norepinephrine. Similar results were obtained with lidocaine. In preparations incubated in solutions containing 3H norepinephrine and mounted for superfusion and isometric tension recording, etidocaine depressed the contractions and diminished the release of 3H norepinephrine evoked by nerve stimulation. Thus, in addition to an inhibitory effect on the responses of smooth muscle cells, amide linked local anesthetic agents such as etidocaine depress adrenergic neurotransmission in the blood vessel wall, which helps explain their vasodilator properties in the intact organism. In unstimulated preparations and during contractions caused by K+, etidocaine increased the efflux of 3H norepinephrine and deaminated metabolites. After incubation with the monoamine oxidase inhibitor, pargyline, etidocaine augmented markedly the efflux of 3H norepinephrine. During responses to tyramine, it augmented the release of 3H norepinephrine more than the efflux of deaminated compounds. This suggests that etidocaine augments the leakage of norepinephrine out of the storage vesicles, making more catecholamines available for intraneuronal deamination. |
Persistent Identifier | http://hdl.handle.net/10722/170519 |
ISSN | 2023 Impact Factor: 3.1 2023 SCImago Journal Rankings: 0.829 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Muldoon, SM | en_US |
dc.contributor.author | Verbeuren, TJ | en_US |
dc.contributor.author | Vanhoutte, PM | en_US |
dc.date.accessioned | 2012-10-30T06:09:47Z | - |
dc.date.available | 2012-10-30T06:09:47Z | - |
dc.date.issued | 1976 | en_US |
dc.identifier.citation | Journal Of Pharmacology And Experimental Therapeutics, 1976, v. 196 n. 3, p. 723-736 | en_US |
dc.identifier.issn | 0022-3565 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170519 | - |
dc.description.abstract | When changes in isometric tension of helical strips of dog saphenous veins were recorded, etidocaine caused a dose dependent depression of the contractile responses to nerve stimulation, norepinephrine and K+. The response to nerve stimulation was significantly more depressed than that to exogenous norepinephrine. Similar results were obtained with lidocaine. In preparations incubated in solutions containing 3H norepinephrine and mounted for superfusion and isometric tension recording, etidocaine depressed the contractions and diminished the release of 3H norepinephrine evoked by nerve stimulation. Thus, in addition to an inhibitory effect on the responses of smooth muscle cells, amide linked local anesthetic agents such as etidocaine depress adrenergic neurotransmission in the blood vessel wall, which helps explain their vasodilator properties in the intact organism. In unstimulated preparations and during contractions caused by K+, etidocaine increased the efflux of 3H norepinephrine and deaminated metabolites. After incubation with the monoamine oxidase inhibitor, pargyline, etidocaine augmented markedly the efflux of 3H norepinephrine. During responses to tyramine, it augmented the release of 3H norepinephrine more than the efflux of deaminated compounds. This suggests that etidocaine augments the leakage of norepinephrine out of the storage vesicles, making more catecholamines available for intraneuronal deamination. | en_US |
dc.language | eng | en_US |
dc.publisher | American Society for Pharmacology and Experimental Therapeutics. The Journal's web site is located at http://jpet.aspetjournals.org | en_US |
dc.relation.ispartof | Journal of Pharmacology and Experimental Therapeutics | en_US |
dc.subject.mesh | Amides - Pharmacology | en_US |
dc.subject.mesh | Anesthetics, Local - Pharmacology | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Dogs | en_US |
dc.subject.mesh | Electric Stimulation | en_US |
dc.subject.mesh | Neuroeffector Junction - Drug Effects | en_US |
dc.subject.mesh | Norepinephrine - Metabolism - Pharmacology | en_US |
dc.subject.mesh | Potassium - Pharmacology | en_US |
dc.subject.mesh | Saphenous Vein - Drug Effects - Physiology | en_US |
dc.subject.mesh | Sympathetic Nervous System - Drug Effects | en_US |
dc.subject.mesh | Synaptic Transmission - Drug Effects | en_US |
dc.subject.mesh | Tyramine - Pharmacology | en_US |
dc.title | Effects of amide linked local anesthetics on adrenergic neuroeffector junction in cutaneous veins of dog | en_US |
dc.type | Article | en_US |
dc.identifier.email | Vanhoutte, PM:vanhoutt@hku.hk | en_US |
dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.pmid | 177755 | - |
dc.identifier.scopus | eid_2-s2.0-0017249672 | en_US |
dc.identifier.volume | 196 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 723 | en_US |
dc.identifier.epage | 736 | en_US |
dc.identifier.isi | WOS:A1976BM51100021 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Muldoon, SM=7006041150 | en_US |
dc.identifier.scopusauthorid | Verbeuren, TJ=7007006534 | en_US |
dc.identifier.scopusauthorid | Vanhoutte, PM=7202304247 | en_US |
dc.identifier.issnl | 0022-3565 | - |