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- Publisher Website: 10.1128/JVI.02336-05
- Scopus: eid_2-s2.0-33845775710
- PMID: 17035307
- WOS: WOS:000242958600039
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Article: Role for nonstructural protein 1 of severe acute respiratory syndrome coronavirus in chemokine dysregulation
Title | Role for nonstructural protein 1 of severe acute respiratory syndrome coronavirus in chemokine dysregulation |
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Authors | |
Issue Date | 2007 |
Publisher | American Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/ |
Citation | Journal Of Virology, 2007, v. 81 n. 1, p. 416-422 How to Cite? |
Abstract | Severe acute respiratory syndrome (SARS) is an emerging infections disease caused by a novel coronavirus. Since its associated morbidity and mortality have been postulated to be due to. immune dysregulation, we investigated which of the viral proteins is responsible for chemokine overexpression. To delineate the viral and cellular factor interactions, the role of four SARS coronavirus proteins, including nonstructural protein 1 (nsp-1), nsp-5, envelope, and membrane, were examined in terms of cytokine induction. Our results showed that the SARS coronavirus nsp-1 plays an important role in CCL5, CXCL10, and CCL3 expression in human lung epithelial cells via the activation of NF-κB. Copyright © 2007, American Society for Microbiology. All Rights Reserved. |
Persistent Identifier | http://hdl.handle.net/10722/170381 |
ISSN | 2023 Impact Factor: 4.0 2023 SCImago Journal Rankings: 1.378 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Law, AHY | en_US |
dc.contributor.author | Lee, DCW | en_US |
dc.contributor.author | Cheung, BKW | en_US |
dc.contributor.author | Yim, HCH | en_US |
dc.contributor.author | Lau, ASY | en_US |
dc.date.accessioned | 2012-10-30T06:07:55Z | - |
dc.date.available | 2012-10-30T06:07:55Z | - |
dc.date.issued | 2007 | en_US |
dc.identifier.citation | Journal Of Virology, 2007, v. 81 n. 1, p. 416-422 | en_US |
dc.identifier.issn | 0022-538X | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170381 | - |
dc.description.abstract | Severe acute respiratory syndrome (SARS) is an emerging infections disease caused by a novel coronavirus. Since its associated morbidity and mortality have been postulated to be due to. immune dysregulation, we investigated which of the viral proteins is responsible for chemokine overexpression. To delineate the viral and cellular factor interactions, the role of four SARS coronavirus proteins, including nonstructural protein 1 (nsp-1), nsp-5, envelope, and membrane, were examined in terms of cytokine induction. Our results showed that the SARS coronavirus nsp-1 plays an important role in CCL5, CXCL10, and CCL3 expression in human lung epithelial cells via the activation of NF-κB. Copyright © 2007, American Society for Microbiology. All Rights Reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | American Society for Microbiology. The Journal's web site is located at http://jvi.asm.org/ | en_US |
dc.relation.ispartof | Journal of Virology | en_US |
dc.rights | Journal of Virology. Copyright © American Society for Microbiology. | - |
dc.subject.mesh | Chemokine Ccl3 | en_US |
dc.subject.mesh | Chemokine Ccl5 | en_US |
dc.subject.mesh | Chemokine Cxcl10 | en_US |
dc.subject.mesh | Chemokines - Genetics - Metabolism | en_US |
dc.subject.mesh | Chemokines, Cc - Genetics - Metabolism | en_US |
dc.subject.mesh | Chemokines, Cxc - Genetics - Metabolism | en_US |
dc.subject.mesh | Gene Expression Regulation | en_US |
dc.subject.mesh | Nf-Kappa B - Genetics - Metabolism | en_US |
dc.subject.mesh | Respiratory Mucosa - Cytology - Virology | en_US |
dc.subject.mesh | Sars Virus - Metabolism - Pathogenicity | en_US |
dc.subject.mesh | Viral Envelope Proteins - Physiology | en_US |
dc.subject.mesh | Viral Matrix Proteins - Physiology | en_US |
dc.subject.mesh | Viral Nonstructural Proteins - Metabolism | en_US |
dc.title | Role for nonstructural protein 1 of severe acute respiratory syndrome coronavirus in chemokine dysregulation | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lau, ASY:asylau@hku.hk | en_US |
dc.identifier.authority | Lau, ASY=rp00474 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1128/JVI.02336-05 | en_US |
dc.identifier.pmid | 17035307 | - |
dc.identifier.scopus | eid_2-s2.0-33845775710 | en_US |
dc.identifier.hkuros | 126297 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-33845775710&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 81 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 416 | en_US |
dc.identifier.epage | 422 | en_US |
dc.identifier.isi | WOS:000242958600039 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Law, AHY=8692488400 | en_US |
dc.identifier.scopusauthorid | Lee, DCW=15751156000 | en_US |
dc.identifier.scopusauthorid | Cheung, BKW=9634391200 | en_US |
dc.identifier.scopusauthorid | Yim, HCH=15752404600 | en_US |
dc.identifier.scopusauthorid | Lau, ASY=7202626202 | en_US |
dc.identifier.issnl | 0022-538X | - |