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- Publisher Website: 10.4049/jimmunol.177.5.2770
- Scopus: eid_2-s2.0-33747775187
- PMID: 16920911
- WOS: WOS:000240002800007
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Article: Cutting edge: Decreased accumulation and regulatory function of CD4 +CD25 high T cells in human STAT5b deficiency
Title | Cutting edge: Decreased accumulation and regulatory function of CD4 +CD25 high T cells in human STAT5b deficiency |
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Authors | |
Issue Date | 2006 |
Publisher | American Association of Immunologists. The Journal's web site is located at http://www.jimmunol.org |
Citation | Journal Of Immunology, 2006, v. 177 n. 5, p. 2770-2774 How to Cite? |
Abstract | We show that STAT5b is important for the in vivo accumulation of CD4 +CD25 high T cells with regulatory cell function. A patient homozygous for a missense A630P STAT5b mutation displayed immune dysregulation and decreased numbers of CD4 +CD25 high T cells. STAT5b A630P/A630P CD4 +CD25 high T cells had low expression of forkhead box P3 and an impaired ability to suppress the proliferation of or to kill CD4 +CD25 - T cells. Expression of CD25, a component of the high-affinity IL-2R, was also reduced in response to IL-2 or after in vitro propagation. The impact of the STAT5b mutation was selective in that IL-2-mediated up-regulation of the common γ-chain cytokine receptor and perform, and activation-induced expressions of CD154 and IFN-γ were normal. These results indicate that STAT5b propagates an important IL-2-mediated signal for the in vivo accumulation of functional regulatory T cells. Copyright © 2006 by The American Association of Immunologists, Inc. |
Persistent Identifier | http://hdl.handle.net/10722/170375 |
ISSN | 2023 Impact Factor: 3.6 2023 SCImago Journal Rankings: 1.558 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Cohen, AC | en_US |
dc.contributor.author | Nadeau, KC | en_US |
dc.contributor.author | Tu, W | en_US |
dc.contributor.author | Hwa, V | en_US |
dc.contributor.author | Dionis, K | en_US |
dc.contributor.author | Bezrodnik, L | en_US |
dc.contributor.author | Teper, A | en_US |
dc.contributor.author | Gaillard, M | en_US |
dc.contributor.author | Heinrich, J | en_US |
dc.contributor.author | Krensky, AM | en_US |
dc.contributor.author | Rosenfeld, RG | en_US |
dc.contributor.author | Lewis, DB | en_US |
dc.date.accessioned | 2012-10-30T06:07:53Z | - |
dc.date.available | 2012-10-30T06:07:53Z | - |
dc.date.issued | 2006 | en_US |
dc.identifier.citation | Journal Of Immunology, 2006, v. 177 n. 5, p. 2770-2774 | en_US |
dc.identifier.issn | 0022-1767 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170375 | - |
dc.description.abstract | We show that STAT5b is important for the in vivo accumulation of CD4 +CD25 high T cells with regulatory cell function. A patient homozygous for a missense A630P STAT5b mutation displayed immune dysregulation and decreased numbers of CD4 +CD25 high T cells. STAT5b A630P/A630P CD4 +CD25 high T cells had low expression of forkhead box P3 and an impaired ability to suppress the proliferation of or to kill CD4 +CD25 - T cells. Expression of CD25, a component of the high-affinity IL-2R, was also reduced in response to IL-2 or after in vitro propagation. The impact of the STAT5b mutation was selective in that IL-2-mediated up-regulation of the common γ-chain cytokine receptor and perform, and activation-induced expressions of CD154 and IFN-γ were normal. These results indicate that STAT5b propagates an important IL-2-mediated signal for the in vivo accumulation of functional regulatory T cells. Copyright © 2006 by The American Association of Immunologists, Inc. | en_US |
dc.language | eng | en_US |
dc.publisher | American Association of Immunologists. The Journal's web site is located at http://www.jimmunol.org | en_US |
dc.relation.ispartof | Journal of Immunology | en_US |
dc.rights | This is an author-produced version of a manuscript accepted for publication in The Journal of Immunology (The JI). The American Association of Immunologists, Inc. (The AAI), publisher of The JI, holds the copyright to this manuscript. This manuscript has not yet been copyedited or subjected to editorial proofreading by The JI; hence, it may differ from the final version published in The JI (online and in print). The AAI (The JI) is not liable for errors or omissions in this author-produced version of the manuscript or in any version derived from it by the National Institutes of Health or any other third party. The final, citable version of record can be found at www.jimmunol.org | - |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Alanine - Genetics - Metabolism | en_US |
dc.subject.mesh | Cd4-Positive T-Lymphocytes - Cytology - Immunology - Metabolism | en_US |
dc.subject.mesh | Cell Proliferation | en_US |
dc.subject.mesh | Cells, Cultured | en_US |
dc.subject.mesh | Forkhead Transcription Factors - Metabolism | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Lymphocyte Activation - Immunology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Mutation - Genetics | en_US |
dc.subject.mesh | Receptors, Interleukin-2 - Metabolism | en_US |
dc.subject.mesh | Stat5 Transcription Factor - Deficiency - Genetics - Metabolism | en_US |
dc.title | Cutting edge: Decreased accumulation and regulatory function of CD4 +CD25 high T cells in human STAT5b deficiency | en_US |
dc.type | Article | en_US |
dc.identifier.email | Tu, W:wwtu@hkucc.hku.hk | en_US |
dc.identifier.authority | Tu, W=rp00416 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.4049/jimmunol.177.5.2770 | - |
dc.identifier.pmid | 16920911 | - |
dc.identifier.scopus | eid_2-s2.0-33747775187 | en_US |
dc.identifier.hkuros | 179377 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-33747775187&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 177 | en_US |
dc.identifier.issue | 5 | en_US |
dc.identifier.spage | 2770 | en_US |
dc.identifier.epage | 2774 | en_US |
dc.identifier.isi | WOS:000240002800007 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Cohen, AC=36243086800 | en_US |
dc.identifier.scopusauthorid | Nadeau, KC=35305427400 | en_US |
dc.identifier.scopusauthorid | Tu, W=7006479236 | en_US |
dc.identifier.scopusauthorid | Hwa, V=6603892234 | en_US |
dc.identifier.scopusauthorid | Dionis, K=14123041200 | en_US |
dc.identifier.scopusauthorid | Bezrodnik, L=6505819548 | en_US |
dc.identifier.scopusauthorid | Teper, A=6603660317 | en_US |
dc.identifier.scopusauthorid | Gaillard, M=7101778245 | en_US |
dc.identifier.scopusauthorid | Heinrich, J=7201505277 | en_US |
dc.identifier.scopusauthorid | Krensky, AM=7007153789 | en_US |
dc.identifier.scopusauthorid | Rosenfeld, RG=36043783200 | en_US |
dc.identifier.scopusauthorid | Lewis, DB=7404750928 | en_US |
dc.identifier.issnl | 0022-1767 | - |