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- Publisher Website: 10.1203/00006450-199912000-00019
- Scopus: eid_2-s2.0-0345580185
- PMID: 10590034
- WOS: WOS:000083870200018
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Article: IGF-I increases interferon-γ and IL-6 mRNA expression and protein production in neonatal mononuclear cells
Title | IGF-I increases interferon-γ and IL-6 mRNA expression and protein production in neonatal mononuclear cells |
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Authors | |
Issue Date | 1999 |
Publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.pedresearch.org/ |
Citation | Pediatric Research, 1999, v. 46 n. 6, p. 748-754 How to Cite? |
Abstract | Neonates are vulnerable to infections because of their immature immunity. IGF-I has been reported to have profound positive effects on immune function. In this study, we investigated the effects of IGF-I on neonatal immunity. The production of IL-2, IL-4, and interferon-γ in phytohemagglutinin (PHA)-stimulated neonatal mononuclear cells (MNC) was significantly decreased when compared with that of adults. IGF-I alone induced a high level of IL-6 mRNA expression and protein production in neonatal MNC. IGF-I significantly increased mRNA expression and protein production of both IL-6 and interferon-γ but had no influence on that of IL- 2 and IL-4 in PHA-stimulated neonatal MNC. Moreover, it increased neonatal interferon-γ production in PHA-stimulated MNC to a level similar to that of adults. IGF-I could further enhance the mRNA expression of lymphocyte- activation gene 3, which is associated with interferon-γ production and differentiation of T-helper 1 lymphocytes, in PHA-stimulated neonatal MNC. These results suggest IGF-I could promote maturation of neonatal T cells, and its potential use to enhance neonatal immunity deserves further study. |
Persistent Identifier | http://hdl.handle.net/10722/170334 |
ISSN | 2023 Impact Factor: 3.1 2023 SCImago Journal Rankings: 1.184 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Wenwei, T | en_US |
dc.contributor.author | Cheung, PT | en_US |
dc.contributor.author | Lau, YL | en_US |
dc.date.accessioned | 2012-10-30T06:07:33Z | - |
dc.date.available | 2012-10-30T06:07:33Z | - |
dc.date.issued | 1999 | en_US |
dc.identifier.citation | Pediatric Research, 1999, v. 46 n. 6, p. 748-754 | en_US |
dc.identifier.issn | 0031-3998 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170334 | - |
dc.description.abstract | Neonates are vulnerable to infections because of their immature immunity. IGF-I has been reported to have profound positive effects on immune function. In this study, we investigated the effects of IGF-I on neonatal immunity. The production of IL-2, IL-4, and interferon-γ in phytohemagglutinin (PHA)-stimulated neonatal mononuclear cells (MNC) was significantly decreased when compared with that of adults. IGF-I alone induced a high level of IL-6 mRNA expression and protein production in neonatal MNC. IGF-I significantly increased mRNA expression and protein production of both IL-6 and interferon-γ but had no influence on that of IL- 2 and IL-4 in PHA-stimulated neonatal MNC. Moreover, it increased neonatal interferon-γ production in PHA-stimulated MNC to a level similar to that of adults. IGF-I could further enhance the mRNA expression of lymphocyte- activation gene 3, which is associated with interferon-γ production and differentiation of T-helper 1 lymphocytes, in PHA-stimulated neonatal MNC. These results suggest IGF-I could promote maturation of neonatal T cells, and its potential use to enhance neonatal immunity deserves further study. | en_US |
dc.language | eng | en_US |
dc.publisher | Lippincott Williams & Wilkins. The Journal's web site is located at http://www.pedresearch.org/ | en_US |
dc.relation.ispartof | Pediatric Research | en_US |
dc.rights | Pediatric Research. Copyright © Lippincott Williams & Wilkins. | - |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Cells, Cultured | en_US |
dc.subject.mesh | Fetal Blood | en_US |
dc.subject.mesh | Gene Expression Regulation - Drug Effects | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Insulin-Like Growth Factor I - Pharmacology | en_US |
dc.subject.mesh | Interferon-Gamma - Biosynthesis | en_US |
dc.subject.mesh | Interleukin-6 - Biosynthesis | en_US |
dc.subject.mesh | Leukocytes, Mononuclear - Metabolism | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Rna, Messenger - Biosynthesis | en_US |
dc.title | IGF-I increases interferon-γ and IL-6 mRNA expression and protein production in neonatal mononuclear cells | en_US |
dc.type | Article | en_US |
dc.identifier.email | Wenwei, T:wwtu@hkucc.hku.hk | en_US |
dc.identifier.email | Cheung, PT:ptcheung@hkucc.hku.hk | en_US |
dc.identifier.email | Lau, YL:lauylung@hkucc.hku.hk | en_US |
dc.identifier.authority | Wenwei, T=rp00416 | en_US |
dc.identifier.authority | Cheung, PT=rp00351 | en_US |
dc.identifier.authority | Lau, YL=rp00361 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1203/00006450-199912000-00019 | - |
dc.identifier.pmid | 10590034 | - |
dc.identifier.scopus | eid_2-s2.0-0345580185 | en_US |
dc.identifier.hkuros | 47556 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0345580185&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 46 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.spage | 748 | en_US |
dc.identifier.epage | 754 | en_US |
dc.identifier.isi | WOS:000083870200018 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Wenwei, T=7006479236 | en_US |
dc.identifier.scopusauthorid | Cheung, PT=7202595465 | en_US |
dc.identifier.scopusauthorid | Lau, YL=7201403380 | en_US |
dc.identifier.issnl | 0031-3998 | - |