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- Publisher Website: 10.1111/j.1460-9568.1994.tb00263.x
- Scopus: eid_2-s2.0-0028038954
- PMID: 7909483
- WOS: WOS:A1994MW93000005
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Article: Expression of soluble guanylyl cyclase gene in adult rat brain
Title | Expression of soluble guanylyl cyclase gene in adult rat brain |
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Authors | |
Keywords | brain gene expression guanylyl cyclase rat |
Issue Date | 1994 |
Publisher | Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/EJN |
Citation | European Journal Of Neuroscience, 1994, v. 6 n. 2, p. 211-217 How to Cite? |
Abstract | The synthesis of the intracellular messenger, cyclic GMP, is catalysed by particulate or soluble guanylyl cyclase (sGCY). sGCY is activated by nitric oxide, a compound with putative neurotransmitter functions, especially in long-term potentiation. Hybridization histochemistry with a probe complementary to the rat lung large (α1) subunit was used to assess the exact localization of sGCY mRNA in the rat brain. Many cells in the olfactory bulb contained sGCY mRNA. In the whole cerebral cortex, sGCY mRNA was found in all layers, with a predominance in layers II - III. A similar pattern was found in the olfactory tuberculum, in continuation with the piriform cortex and the cortical amygdaloid nucleus. All parts of the striatum expressed sGCY mRNA. sGCY mRNA was also found in the habenula medialis, in the pinealis in some diencephalic nuclei, and in the granule cell layers of the cerebellum. This study provides a description of the normal anatomy of sGCY gene expression in the rat forebrain as a basis for the study of the modulation of expression after physiological and pharmacological manipulations. |
Persistent Identifier | http://hdl.handle.net/10722/170273 |
ISSN | 2023 Impact Factor: 2.7 2023 SCImago Journal Rankings: 1.129 |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Burgunder, JM | en_US |
dc.contributor.author | Cheung, PT | en_US |
dc.date.accessioned | 2012-10-30T06:07:07Z | - |
dc.date.available | 2012-10-30T06:07:07Z | - |
dc.date.issued | 1994 | en_US |
dc.identifier.citation | European Journal Of Neuroscience, 1994, v. 6 n. 2, p. 211-217 | en_US |
dc.identifier.issn | 0953-816X | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170273 | - |
dc.description.abstract | The synthesis of the intracellular messenger, cyclic GMP, is catalysed by particulate or soluble guanylyl cyclase (sGCY). sGCY is activated by nitric oxide, a compound with putative neurotransmitter functions, especially in long-term potentiation. Hybridization histochemistry with a probe complementary to the rat lung large (α1) subunit was used to assess the exact localization of sGCY mRNA in the rat brain. Many cells in the olfactory bulb contained sGCY mRNA. In the whole cerebral cortex, sGCY mRNA was found in all layers, with a predominance in layers II - III. A similar pattern was found in the olfactory tuberculum, in continuation with the piriform cortex and the cortical amygdaloid nucleus. All parts of the striatum expressed sGCY mRNA. sGCY mRNA was also found in the habenula medialis, in the pinealis in some diencephalic nuclei, and in the granule cell layers of the cerebellum. This study provides a description of the normal anatomy of sGCY gene expression in the rat forebrain as a basis for the study of the modulation of expression after physiological and pharmacological manipulations. | en_US |
dc.language | eng | en_US |
dc.publisher | Blackwell Publishing Ltd. The Journal's web site is located at http://www.blackwellpublishing.com/journals/EJN | en_US |
dc.relation.ispartof | European Journal of Neuroscience | en_US |
dc.subject | brain | - |
dc.subject | gene expression | - |
dc.subject | guanylyl cyclase | - |
dc.subject | rat | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Blotting, Northern | en_US |
dc.subject.mesh | Brain - Cytology - Enzymology | en_US |
dc.subject.mesh | Gene Expression | en_US |
dc.subject.mesh | Guanylate Cyclase - Biosynthesis | en_US |
dc.subject.mesh | In Situ Hybridization | en_US |
dc.subject.mesh | Lung - Enzymology | en_US |
dc.subject.mesh | Organ Specificity | en_US |
dc.subject.mesh | Rna, Messenger - Analysis - Biosynthesis | en_US |
dc.subject.mesh | Rats | en_US |
dc.title | Expression of soluble guanylyl cyclase gene in adult rat brain | en_US |
dc.type | Article | en_US |
dc.identifier.email | Cheung, PT:ptcheung@hkucc.hku.hk | en_US |
dc.identifier.authority | Cheung, PT=rp00351 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1111/j.1460-9568.1994.tb00263.x | - |
dc.identifier.pmid | 7909483 | - |
dc.identifier.scopus | eid_2-s2.0-0028038954 | en_US |
dc.identifier.volume | 6 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 211 | en_US |
dc.identifier.epage | 217 | en_US |
dc.identifier.isi | WOS:A1994MW93000005 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Burgunder, JM=7005647679 | en_US |
dc.identifier.scopusauthorid | Cheung, PT=7202595465 | en_US |
dc.identifier.issnl | 0953-816X | - |