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- Publisher Website: 10.3109/15563659008994438
- Scopus: eid_2-s2.0-0025221340
- PMID: 2231836
- WOS: WOS:A1990EJ65300011
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Article: Clinical course and pharmacokinetics following a massive overdose of Amphotericin B in a neonate
Title | Clinical course and pharmacokinetics following a massive overdose of Amphotericin B in a neonate |
---|---|
Authors | |
Issue Date | 1990 |
Citation | Journal Of Toxicology - Clinical Toxicology, 1990, v. 28 n. 3, p. 371-378 How to Cite? |
Abstract | Amphotericin is the drug of choice for the treatment of fungal infections in infants and children. When used in the recommended doses, amphotericin therapy is associated with high rates of adverse effects, including nephrotoxicity, hepatotoxicity, decrease in white blood cells, platelets and hemoglobin, chills, fever and even death. We report a case involving a neonate who was exposed to a 50 fold overdose of Amphotericin over a three day period. |
Persistent Identifier | http://hdl.handle.net/10722/170240 |
ISSN | |
ISI Accession Number ID |
DC Field | Value | Language |
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dc.contributor.author | Koren, G | en_US |
dc.contributor.author | Lau, A | en_US |
dc.contributor.author | Kenyon, CF | en_US |
dc.contributor.author | Kroppert, D | en_US |
dc.contributor.author | Klein, J | en_US |
dc.date.accessioned | 2012-10-30T06:06:54Z | - |
dc.date.available | 2012-10-30T06:06:54Z | - |
dc.date.issued | 1990 | en_US |
dc.identifier.citation | Journal Of Toxicology - Clinical Toxicology, 1990, v. 28 n. 3, p. 371-378 | en_US |
dc.identifier.issn | 0731-3810 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/170240 | - |
dc.description.abstract | Amphotericin is the drug of choice for the treatment of fungal infections in infants and children. When used in the recommended doses, amphotericin therapy is associated with high rates of adverse effects, including nephrotoxicity, hepatotoxicity, decrease in white blood cells, platelets and hemoglobin, chills, fever and even death. We report a case involving a neonate who was exposed to a 50 fold overdose of Amphotericin over a three day period. | en_US |
dc.language | eng | en_US |
dc.relation.ispartof | Journal of Toxicology - Clinical Toxicology | en_US |
dc.subject.mesh | Amphotericin B - Pharmacokinetics - Poisoning - Therapeutic Use | en_US |
dc.subject.mesh | Candidiasis - Cerebrospinal Fluid - Drug Therapy | en_US |
dc.subject.mesh | Follow-Up Studies | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Infant, Newborn | en_US |
dc.subject.mesh | Overdose - Metabolism | en_US |
dc.title | Clinical course and pharmacokinetics following a massive overdose of Amphotericin B in a neonate | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lau, A:asylau@hku.hk | en_US |
dc.identifier.authority | Lau, A=rp00474 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.3109/15563659008994438 | - |
dc.identifier.pmid | 2231836 | - |
dc.identifier.scopus | eid_2-s2.0-0025221340 | en_US |
dc.identifier.volume | 28 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 371 | en_US |
dc.identifier.epage | 378 | en_US |
dc.identifier.isi | WOS:A1990EJ65300011 | - |
dc.identifier.scopusauthorid | Koren, G=36042259400 | en_US |
dc.identifier.scopusauthorid | Lau, A=7202626202 | en_US |
dc.identifier.scopusauthorid | Kenyon, CF=7103045851 | en_US |
dc.identifier.scopusauthorid | Kroppert, D=6504768820 | en_US |
dc.identifier.scopusauthorid | Klein, J=7404605257 | en_US |
dc.identifier.issnl | 0731-3810 | - |