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Article: Clinical course and pharmacokinetics following a massive overdose of Amphotericin B in a neonate

TitleClinical course and pharmacokinetics following a massive overdose of Amphotericin B in a neonate
Authors
Koren, GLau, AKenyon, CFKroppert, DKlein, J
Issue Date1990
Citation
Journal Of Toxicology - Clinical Toxicology, 1990, v. 28 n. 3, p. 371-378 How to Cite?
DOI: http://dx.doi.org/10.3109/15563659008994438
AbstractAmphotericin is the drug of choice for the treatment of fungal infections in infants and children. When used in the recommended doses, amphotericin therapy is associated with high rates of adverse effects, including nephrotoxicity, hepatotoxicity, decrease in white blood cells, platelets and hemoglobin, chills, fever and even death. We report a case involving a neonate who was exposed to a 50 fold overdose of Amphotericin over a three day period.
Persistent Identifierhttp://hdl.handle.net/10722/170240
ISSN
0731-3810
ISI Accession Number ID
WOS:A1990EJ65300011

 

DC FieldValueLanguage
dc.contributor.authorKoren, Gen_US
dc.contributor.authorLau, Aen_US
dc.contributor.authorKenyon, CFen_US
dc.contributor.authorKroppert, Den_US
dc.contributor.authorKlein, Jen_US
dc.date.accessioned2012-10-30T06:06:54Z-
dc.date.available2012-10-30T06:06:54Z-
dc.date.issued1990en_US
dc.identifier.citationJournal Of Toxicology - Clinical Toxicology, 1990, v. 28 n. 3, p. 371-378en_US
dc.identifier.issn0731-3810en_US
dc.identifier.urihttp://hdl.handle.net/10722/170240-
dc.description.abstractAmphotericin is the drug of choice for the treatment of fungal infections in infants and children. When used in the recommended doses, amphotericin therapy is associated with high rates of adverse effects, including nephrotoxicity, hepatotoxicity, decrease in white blood cells, platelets and hemoglobin, chills, fever and even death. We report a case involving a neonate who was exposed to a 50 fold overdose of Amphotericin over a three day period.en_US
dc.languageengen_US
dc.relation.ispartofJournal of Toxicology - Clinical Toxicologyen_US
dc.subject.meshAmphotericin B - Pharmacokinetics - Poisoning - Therapeutic Useen_US
dc.subject.meshCandidiasis - Cerebrospinal Fluid - Drug Therapyen_US
dc.subject.meshFollow-Up Studiesen_US
dc.subject.meshHumansen_US
dc.subject.meshInfant, Newbornen_US
dc.subject.meshOverdose - Metabolismen_US
dc.titleClinical course and pharmacokinetics following a massive overdose of Amphotericin B in a neonateen_US
dc.typeArticleen_US
dc.identifier.emailLau, A:asylau@hku.hken_US
dc.identifier.authorityLau, A=rp00474en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.3109/15563659008994438-
dc.identifier.pmid2231836-
dc.identifier.scopuseid_2-s2.0-0025221340en_US
dc.identifier.volume28en_US
dc.identifier.issue3en_US
dc.identifier.spage371en_US
dc.identifier.epage378en_US
dc.identifier.isiWOS:A1990EJ65300011-
dc.identifier.scopusauthoridKoren, G=36042259400en_US
dc.identifier.scopusauthoridLau, A=7202626202en_US
dc.identifier.scopusauthoridKenyon, CF=7103045851en_US
dc.identifier.scopusauthoridKroppert, D=6504768820en_US
dc.identifier.scopusauthoridKlein, J=7404605257en_US
dc.identifier.issnl0731-3810-

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