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Article: The effect of strontium incorporation into hydroxyapatites on their physical and biological properties

TitleThe effect of strontium incorporation into hydroxyapatites on their physical and biological properties
Authors
Ni, GXShu, BHuang, GLu, WWPan, HB
KeywordsDifferentiation
Hydroxyapatite
Mscs
Solubility
Strontium
Issue Date2012
PublisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-9304:1/
Citation
Journal Of Biomedical Materials Research - Part B Applied Biomaterials, 2012, v. 100 B n. 2, p. 562-568 How to Cite?
DOI: http://dx.doi.org/10.1002/jbm.b.31986
AbstractIn this study, the effects of a series of strontium (Sr)-substituted HA ceramics (0, 1, 5, and 10 mol % Sr substitution) were tested on their physical and biological properties. The crystal structure, composition, and solubility were investigated by TEM, XRD, and solid titration solubility isotherms, respectively. In addition, rat MSCs were cultured with culture media containing ions released from the strontium-substituted HA ceramics as they dissolved. MTT test, alkaline phosphatase activity, and osteoblast transcription factor gene (cbfa1) expression were conducted at different time points. Our results suggested that HA with Sr substitution may change its physical properties, especially its solubility, and consequently enhance undifferentiated MSCs into osteoblast lineage. The results from this and the previous study suggested that 5-10 mol % Sr substitution into HA may be a suitable choice for its use in bone regenerative field. © 2011 Wiley Periodicals, Inc.
Persistent Identifierhttp://hdl.handle.net/10722/170191
ISSN
1552-4973
2021 Impact Factor: 3.405
2020 SCImago Journal Rankings: 0.665
ISI Accession Number ID
WOS:000298792500030
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorNi, GXen_US
dc.contributor.authorShu, Ben_US
dc.contributor.authorHuang, Gen_US
dc.contributor.authorLu, WWen_US
dc.contributor.authorPan, HBen_US
dc.date.accessioned2012-10-30T06:06:00Z-
dc.date.available2012-10-30T06:06:00Z-
dc.date.issued2012en_US
dc.identifier.citationJournal Of Biomedical Materials Research - Part B Applied Biomaterials, 2012, v. 100 B n. 2, p. 562-568en_US
dc.identifier.issn1552-4973en_US
dc.identifier.urihttp://hdl.handle.net/10722/170191-
dc.description.abstractIn this study, the effects of a series of strontium (Sr)-substituted HA ceramics (0, 1, 5, and 10 mol % Sr substitution) were tested on their physical and biological properties. The crystal structure, composition, and solubility were investigated by TEM, XRD, and solid titration solubility isotherms, respectively. In addition, rat MSCs were cultured with culture media containing ions released from the strontium-substituted HA ceramics as they dissolved. MTT test, alkaline phosphatase activity, and osteoblast transcription factor gene (cbfa1) expression were conducted at different time points. Our results suggested that HA with Sr substitution may change its physical properties, especially its solubility, and consequently enhance undifferentiated MSCs into osteoblast lineage. The results from this and the previous study suggested that 5-10 mol % Sr substitution into HA may be a suitable choice for its use in bone regenerative field. © 2011 Wiley Periodicals, Inc.en_US
dc.languageengen_US
dc.publisherJohn Wiley & Sons, Inc. The Journal's web site is located at http://www.interscience.wiley.com/jpages/0021-9304:1/en_US
dc.relation.ispartofJournal of Biomedical Materials Research - Part B Applied Biomaterialsen_US
dc.subjectDifferentiationen_US
dc.subjectHydroxyapatiteen_US
dc.subjectMscsen_US
dc.subjectSolubilityen_US
dc.subjectStrontiumen_US
dc.titleThe effect of strontium incorporation into hydroxyapatites on their physical and biological propertiesen_US
dc.typeArticleen_US
dc.identifier.emailLu, WW:wwlu@hku.hken_US
dc.identifier.emailPan, HB:haobo@hku.hken_US
dc.identifier.authorityLu, WW=rp00411en_US
dc.identifier.authorityPan, HB=rp01564en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1002/jbm.b.31986en_US
dc.identifier.pmid22114002-
dc.identifier.scopuseid_2-s2.0-84855458972en_US
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-84855458972&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume100 Ben_US
dc.identifier.issue2en_US
dc.identifier.spage562en_US
dc.identifier.epage568en_US
dc.identifier.isiWOS:000298792500030-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridNi, GX=8303037400en_US
dc.identifier.scopusauthoridShu, B=10641286200en_US
dc.identifier.scopusauthoridHuang, G=26025946000en_US
dc.identifier.scopusauthoridLu, WW=7404215221en_US
dc.identifier.scopusauthoridPan, HB=7403295092en_US
dc.identifier.issnl1552-4973-

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