Surface Treatment of Injectable Strontium-Containing Bioactive Bone Cement for Vetebroplasty

Abstract

A novel injectable bioactive bone-bonding cement (SrHAC) composed of strontium-containing hydroxyapatite (Sr-HA) as the inorganic filler and bisphenol A diglycidylether dimethacrylate (Bis-GMA) as the organic matrix for vertebroplasty was developed previously. In this study, the Sr-HA powders were surface treated with methyl methacrylate (MMA) to improve the interface integration of the two phases. After surface treatment, the compression strength and Young's modulus, which were tested after immersion in distilled water at 37 °C for 24 h according to ISO 5833, were increased by 68.65% (p < .001) and 31.02% (p < .001), respectively. The bending strength and bending stiffness of the bioactive bone cement were significantly improved by 54.44% (p < .001) and 83.90% (p < .001). In addition, the handling property of the cement was also enhanced. In vitro biomechanical testing showed that the stiffness of the fractured spine recovered to 82.5% (p < .01) of the intact condition after cementation with surface-treated SrHAC. The failure load of the spine cemented with original and MMA-treated SrHAC improved by 14.25% (p < .05) and 46.91% (p < .05) in comparison with the fractured spines. Results from this study revealed that the MMA-treated SrHAC has a better mechanical effect for orthopedic applications. © 2004 Wiley Periodicals, Inc.