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- Publisher Website: 10.1111/j.1601-0825.2011.01829.x
- Scopus: eid_2-s2.0-80052575518
- PMID: 21771209
- WOS: WOS:000295052100012
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Article: Effect of alendronate on healing of extraction sockets and healing around implants
Title | Effect of alendronate on healing of extraction sockets and healing around implants |
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Authors | |
Keywords | Alendronate Bisphosphonate Bisphosphonate-related osteonecrosis of the jaw Empty lacuna Extraction Implant Osteoporosis |
Issue Date | 2011 |
Publisher | Wiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1354-523X&site=1 |
Citation | Oral Diseases, 2011, v. 17 n. 7, p. 705-711 How to Cite? |
Abstract | Objectives: The purpose of this study was to evaluate the effect of alendronates on healing of extraction sockets and healing around implants in the maxilla of rats. Materials and Methods: Twenty-four Sprague-Dawley rats were used. The rats in bisphosphonate group were subcutaneously injected with alendronate (5.0mg kg --1) three times a week for 4weeks. Both sides of the maxillary first molars were extracted, and customized titanium implants (Ø1.5×2.0mm) were placed immediately into one side. Rats were killed at 3, 7, 14, or 28days following surgery. Results: New bone formation in extraction sockets, bone area around the implant site, and bone-implant contact were not delayed in the bisphosphonate group. The tartrate-resistant acid phosphatase positive cell count did not differ between bisphosphonate and control groups; however, empty lacunae were observed significantly more in bisphosphonate group. The differences in empty lacunae were shown at different time points between the implant sites and extraction sites: at 7days after extraction, and at 14 and 28days after implantation. Conclusions: Alendronates seemed to decrease bone resorption but not to decrease bone formation. Empty lacunae were observed significantly more at later time points in implant sites compared to extraction sockets. © 2011 John Wiley & Sons A/S. |
Persistent Identifier | http://hdl.handle.net/10722/169583 |
ISSN | 2023 Impact Factor: 2.9 2023 SCImago Journal Rankings: 0.895 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kim, JH | en_US |
dc.contributor.author | Park, YB | en_US |
dc.contributor.author | Li, Z | en_US |
dc.contributor.author | Shim, JS | en_US |
dc.contributor.author | Moon, HS | en_US |
dc.contributor.author | Jung, HS | en_US |
dc.contributor.author | Chung, MK | en_US |
dc.date.accessioned | 2012-10-25T04:53:08Z | - |
dc.date.available | 2012-10-25T04:53:08Z | - |
dc.date.issued | 2011 | en_US |
dc.identifier.citation | Oral Diseases, 2011, v. 17 n. 7, p. 705-711 | en_US |
dc.identifier.issn | 1354-523X | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/169583 | - |
dc.description.abstract | Objectives: The purpose of this study was to evaluate the effect of alendronates on healing of extraction sockets and healing around implants in the maxilla of rats. Materials and Methods: Twenty-four Sprague-Dawley rats were used. The rats in bisphosphonate group were subcutaneously injected with alendronate (5.0mg kg --1) three times a week for 4weeks. Both sides of the maxillary first molars were extracted, and customized titanium implants (Ø1.5×2.0mm) were placed immediately into one side. Rats were killed at 3, 7, 14, or 28days following surgery. Results: New bone formation in extraction sockets, bone area around the implant site, and bone-implant contact were not delayed in the bisphosphonate group. The tartrate-resistant acid phosphatase positive cell count did not differ between bisphosphonate and control groups; however, empty lacunae were observed significantly more in bisphosphonate group. The differences in empty lacunae were shown at different time points between the implant sites and extraction sites: at 7days after extraction, and at 14 and 28days after implantation. Conclusions: Alendronates seemed to decrease bone resorption but not to decrease bone formation. Empty lacunae were observed significantly more at later time points in implant sites compared to extraction sockets. © 2011 John Wiley & Sons A/S. | en_US |
dc.language | eng | en_US |
dc.publisher | Wiley-Blackwell Publishing, Inc.. The Journal's web site is located at http://www.wiley.com/bw/journal.asp?ref=1354-523X&site=1 | en_US |
dc.relation.ispartof | Oral Diseases | en_US |
dc.subject | Alendronate | - |
dc.subject | Bisphosphonate | - |
dc.subject | Bisphosphonate-related osteonecrosis of the jaw | - |
dc.subject | Empty lacuna | - |
dc.subject | Extraction | - |
dc.subject | Implant | - |
dc.subject | Osteoporosis | - |
dc.subject.mesh | Acid Phosphatase - Analysis | en_US |
dc.subject.mesh | Alendronate - Pharmacology | en_US |
dc.subject.mesh | Alveolar Bone Loss - Prevention & Control | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Azo Compounds - Diagnostic Use | en_US |
dc.subject.mesh | Biological Markers - Analysis | en_US |
dc.subject.mesh | Bone Density Conservation Agents - Pharmacology | en_US |
dc.subject.mesh | Collagen Type I - Analysis | en_US |
dc.subject.mesh | Coloring Agents - Diagnostic Use | en_US |
dc.subject.mesh | Dental Implantation, Endosseous - Instrumentation | en_US |
dc.subject.mesh | Dental Implants | en_US |
dc.subject.mesh | Dental Materials - Chemistry | en_US |
dc.subject.mesh | Eosine Yellowish-(Ys) - Diagnostic Use | en_US |
dc.subject.mesh | Isoenzymes - Analysis | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Maxilla - Drug Effects - Pathology | en_US |
dc.subject.mesh | Methyl Green - Diagnostic Use | en_US |
dc.subject.mesh | Molar - Surgery | en_US |
dc.subject.mesh | Osseointegration - Drug Effects | en_US |
dc.subject.mesh | Osteoclasts - Pathology | en_US |
dc.subject.mesh | Osteogenesis - Drug Effects | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Rats, Sprague-Dawley | en_US |
dc.subject.mesh | Time Factors | en_US |
dc.subject.mesh | Titanium - Chemistry | en_US |
dc.subject.mesh | Tooth Extraction | en_US |
dc.subject.mesh | Tooth Socket - Drug Effects - Pathology | en_US |
dc.subject.mesh | Wound Healing - Drug Effects | en_US |
dc.title | Effect of alendronate on healing of extraction sockets and healing around implants | en_US |
dc.type | Article | en_US |
dc.identifier.email | Jung, HS: hsjung@yuhs.ac | en_US |
dc.identifier.authority | Jung, HS=rp01683 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1111/j.1601-0825.2011.01829.x | en_US |
dc.identifier.pmid | 21771209 | - |
dc.identifier.scopus | eid_2-s2.0-80052575518 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-80052575518&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 17 | en_US |
dc.identifier.issue | 7 | en_US |
dc.identifier.spage | 705 | en_US |
dc.identifier.epage | 711 | en_US |
dc.identifier.isi | WOS:000295052100012 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Kim, JH=51763838500 | en_US |
dc.identifier.scopusauthorid | Park, YB=7405369878 | en_US |
dc.identifier.scopusauthorid | Li, Z=51763934300 | en_US |
dc.identifier.scopusauthorid | Shim, JS=35325524200 | en_US |
dc.identifier.scopusauthorid | Moon, HS=36912762000 | en_US |
dc.identifier.scopusauthorid | Jung, HS=7403030195 | en_US |
dc.identifier.scopusauthorid | Chung, MK=36514262900 | en_US |
dc.identifier.issnl | 1354-523X | - |