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Conference Paper: Structural characterization and anti-HIV-1 activities of arginine/glutamate-rich polypeptide luffin P1 from the seeds of sponge gourd (Luffa Cylindrica)

TitleStructural characterization and anti-HIV-1 activities of arginine/glutamate-rich polypeptide luffin P1 from the seeds of sponge gourd (Luffa Cylindrica)
Authors
Yang, YHNg, YMSze, KHZhang, XZheng, YTShaw, PC
Issue Date2011
Citation
The 2011 Croucher Advanced Study Institute Conference on Structure-Based Sreening and Design of Ligands for Protein Targets, Hong Kong, 12-15 December 2011. How to Cite?
AbstractLuffin P1, the smallest ribosome‐inactivating peptide from the seeds of Luffa cylindrica was found to have anti‐HIV‐1 activity in HIV‐1 infected C8166 T‐cell lines and be able to bind with HIV Rev Response Element. Nuclear magnetic resonance spectroscopy revealed that the Luffin P1 comprises a helix‐loop‐helix motif, with the two alpha helices tightly associated by two disulfide bonds. Based on our findings, we conclude that unlike the well‐studied ribosome‐inactivating proteins, which exert their action through N‐glycosidase activities …
DescriptionPoster Presentation: abstract no. A19
Persistent Identifierhttp://hdl.handle.net/10722/169362

 

DC FieldValueLanguage
dc.contributor.authorYang, YHen_US
dc.contributor.authorNg, YMen_US
dc.contributor.authorSze, KHen_US
dc.contributor.authorZhang, Xen_US
dc.contributor.authorZheng, YTen_US
dc.contributor.authorShaw, PCen_US
dc.date.accessioned2012-10-18T08:51:06Z-
dc.date.available2012-10-18T08:51:06Z-
dc.date.issued2011en_US
dc.identifier.citationThe 2011 Croucher Advanced Study Institute Conference on Structure-Based Sreening and Design of Ligands for Protein Targets, Hong Kong, 12-15 December 2011.en_US
dc.identifier.urihttp://hdl.handle.net/10722/169362-
dc.descriptionPoster Presentation: abstract no. A19-
dc.description.abstractLuffin P1, the smallest ribosome‐inactivating peptide from the seeds of Luffa cylindrica was found to have anti‐HIV‐1 activity in HIV‐1 infected C8166 T‐cell lines and be able to bind with HIV Rev Response Element. Nuclear magnetic resonance spectroscopy revealed that the Luffin P1 comprises a helix‐loop‐helix motif, with the two alpha helices tightly associated by two disulfide bonds. Based on our findings, we conclude that unlike the well‐studied ribosome‐inactivating proteins, which exert their action through N‐glycosidase activities …-
dc.languageengen_US
dc.relation.ispartofCroucher ASI Conference on Structure-Based Sreening and Design of Ligands for Protein Targetsen_US
dc.titleStructural characterization and anti-HIV-1 activities of arginine/glutamate-rich polypeptide luffin P1 from the seeds of sponge gourd (Luffa Cylindrica)en_US
dc.typeConference_Paperen_US
dc.identifier.emailSze, KH: khsze@hku.hken_US
dc.identifier.authoritySze, KH=rp00785en_US
dc.description.naturepostprint-
dc.identifier.hkuros211869en_US

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