File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1016/j.freeradbiomed.2011.01.011
- Scopus: eid_2-s2.0-79952444868
- PMID: 21241794
- WOS: WOS:000288818100001
- Find via
Supplementary
-
Bookmarks:
- CiteULike: 1
- Citations:
- Appears in Collections:
Article: The role of the Golgi apparatus in oxidative stress: Is this organelle less significant than mitochondria?
Title | The role of the Golgi apparatus in oxidative stress: Is this organelle less significant than mitochondria? |
---|---|
Authors | |
Keywords | Antioxidant components Ca2+/Mn2+ homeostasis Fragmentation Free radicals Golgi apparatus Oxidative stress Signaling transduction Sphingolipid metabolism |
Issue Date | 2011 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/freeradbiomed |
Citation | Free Radical Biology And Medicine, 2011, v. 50 n. 8, p. 907-917 How to Cite? |
Abstract | Reactive oxygen species (ROS)/reactive nitrogen species (RNS) and ROS/RNS-mediated oxidative stress have well-established roles in many physiological and pathological processes and are associated with the pathogenesis of many diseases, such as hypertension, ischemia/reperfusion injury, diabetes mellitus, atherosclerosis, stroke, cancer, and neurodegenerative disorders. It is generally accepted that mitochondria play an essential role in oxidative stress because they are responsible for the primary generation of superoxide radicals. Little attention, however, has been paid to the importance of the Golgi apparatus (GA) in this process. The GA is a pivotal organelle in cell metabolism and participates in modifying, sorting, and packaging macromolecules for cell secretion or use within the cell. It is inevitably involved in the process of oxidative stress, which can cause modification and damage of lipids, proteins, DNA, and other structural constituents. Here we discuss the connections between the GA and oxidative stress and highlight the role of the GA in oxidative stress-related Ca 2+/Mn 2+ homeostasis, cell apoptosis, sphingolipid metabolism, signal transduction, and antioxidation. We also provide a novel perspective on the subcellular significance of oxidative stress and its pathological implications and present "GA stress" as a new concept to explain the GA-specific stress response. © 2011 Elsevier Inc. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/168514 |
ISSN | 2023 Impact Factor: 7.1 2023 SCImago Journal Rankings: 1.752 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Jiang, Z | en_US |
dc.contributor.author | Hu, Z | en_US |
dc.contributor.author | Zeng, L | en_US |
dc.contributor.author | Lu, W | en_US |
dc.contributor.author | Zhang, H | en_US |
dc.contributor.author | Li, T | en_US |
dc.contributor.author | Xiao, H | en_US |
dc.date.accessioned | 2012-10-08T03:19:52Z | - |
dc.date.available | 2012-10-08T03:19:52Z | - |
dc.date.issued | 2011 | en_US |
dc.identifier.citation | Free Radical Biology And Medicine, 2011, v. 50 n. 8, p. 907-917 | en_US |
dc.identifier.issn | 0891-5849 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/168514 | - |
dc.description.abstract | Reactive oxygen species (ROS)/reactive nitrogen species (RNS) and ROS/RNS-mediated oxidative stress have well-established roles in many physiological and pathological processes and are associated with the pathogenesis of many diseases, such as hypertension, ischemia/reperfusion injury, diabetes mellitus, atherosclerosis, stroke, cancer, and neurodegenerative disorders. It is generally accepted that mitochondria play an essential role in oxidative stress because they are responsible for the primary generation of superoxide radicals. Little attention, however, has been paid to the importance of the Golgi apparatus (GA) in this process. The GA is a pivotal organelle in cell metabolism and participates in modifying, sorting, and packaging macromolecules for cell secretion or use within the cell. It is inevitably involved in the process of oxidative stress, which can cause modification and damage of lipids, proteins, DNA, and other structural constituents. Here we discuss the connections between the GA and oxidative stress and highlight the role of the GA in oxidative stress-related Ca 2+/Mn 2+ homeostasis, cell apoptosis, sphingolipid metabolism, signal transduction, and antioxidation. We also provide a novel perspective on the subcellular significance of oxidative stress and its pathological implications and present "GA stress" as a new concept to explain the GA-specific stress response. © 2011 Elsevier Inc. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/freeradbiomed | en_US |
dc.relation.ispartof | Free Radical Biology and Medicine | en_US |
dc.subject | Antioxidant components | - |
dc.subject | Ca2+/Mn2+ homeostasis | - |
dc.subject | Fragmentation | - |
dc.subject | Free radicals | - |
dc.subject | Golgi apparatus | - |
dc.subject | Oxidative stress | - |
dc.subject | Signaling transduction | - |
dc.subject | Sphingolipid metabolism | - |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Golgi Apparatus - Physiology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Mitochondria - Metabolism | en_US |
dc.subject.mesh | Oxidative Stress | en_US |
dc.subject.mesh | Rats | en_US |
dc.subject.mesh | Species Specificity | en_US |
dc.title | The role of the Golgi apparatus in oxidative stress: Is this organelle less significant than mitochondria? | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lu, W:luwei@hku.hk | en_US |
dc.identifier.authority | Lu, W=rp00754 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.freeradbiomed.2011.01.011 | en_US |
dc.identifier.pmid | 21241794 | - |
dc.identifier.scopus | eid_2-s2.0-79952444868 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-79952444868&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 50 | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.spage | 907 | en_US |
dc.identifier.epage | 917 | en_US |
dc.identifier.isi | WOS:000288818100001 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Jiang, Z=41861691600 | en_US |
dc.identifier.scopusauthorid | Hu, Z=7404210124 | en_US |
dc.identifier.scopusauthorid | Zeng, L=16647753300 | en_US |
dc.identifier.scopusauthorid | Lu, W=27868087600 | en_US |
dc.identifier.scopusauthorid | Zhang, H=35867714100 | en_US |
dc.identifier.scopusauthorid | Li, T=36096818400 | en_US |
dc.identifier.scopusauthorid | Xiao, H=41862644200 | en_US |
dc.identifier.citeulike | 8643362 | - |
dc.identifier.issnl | 0891-5849 | - |