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- Publisher Website: 10.1002/asia.200900636
- Scopus: eid_2-s2.0-77952909043
- PMID: 20408163
- WOS: WOS:000278840200014
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Article: Conformational studies on peptides of α-aminoxy acids with functionalized side-chains
Title | Conformational studies on peptides of α-aminoxy acids with functionalized side-chains |
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Authors | |
Keywords | Circular dichroism Conformation analysis Gelical structures Hydrogen bonds Peptides |
Issue Date | 2010 |
Publisher | Wiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www.wiley-vch.de/publish/en/journals/alphabeticIndex/2451 |
Citation | Chemistry - An Asian Journal, 2010, v. 5 n. 6, p. 1356-1363 How to Cite? |
Abstract | Peptides of homochiral α- aminoxy acids of nonpolar side chains can form a 1.88-helix. In this paper, we report the conformational studies of α- aminoxy peptides 1-3, which have functionalized side chains, in both non- polar and polar solvents. 1H NMR, XRD, and FTIR absorption studies confirm the presence of the eight-membered-ring intramolecular hydrogen bonds (the N-O turns) in nonpolar solvents as well as in methanol. CD studies of peptides 1-3 in different solvents indicate that a substantial degree of helical content is retained in methanol and acidic aqueous buffers. The introduction of functionalized side chains in α-aminoxy peptides provides opportunities for designing biologically active peptides. |
Persistent Identifier | http://hdl.handle.net/10722/168460 |
ISSN | 2023 Impact Factor: 3.5 2023 SCImago Journal Rankings: 0.846 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Yang, D | en_HK |
dc.contributor.author | Liu, GJ | en_HK |
dc.contributor.author | Hao, Y | en_HK |
dc.contributor.author | Li, W | en_HK |
dc.contributor.author | Dong, ZM | en_HK |
dc.contributor.author | Zhang, DW | en_HK |
dc.contributor.author | Zhu, NY | en_HK |
dc.date.accessioned | 2012-10-08T03:19:12Z | - |
dc.date.available | 2012-10-08T03:19:12Z | - |
dc.date.issued | 2010 | en_HK |
dc.identifier.citation | Chemistry - An Asian Journal, 2010, v. 5 n. 6, p. 1356-1363 | en_HK |
dc.identifier.issn | 1861-4728 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/168460 | - |
dc.description.abstract | Peptides of homochiral α- aminoxy acids of nonpolar side chains can form a 1.88-helix. In this paper, we report the conformational studies of α- aminoxy peptides 1-3, which have functionalized side chains, in both non- polar and polar solvents. 1H NMR, XRD, and FTIR absorption studies confirm the presence of the eight-membered-ring intramolecular hydrogen bonds (the N-O turns) in nonpolar solvents as well as in methanol. CD studies of peptides 1-3 in different solvents indicate that a substantial degree of helical content is retained in methanol and acidic aqueous buffers. The introduction of functionalized side chains in α-aminoxy peptides provides opportunities for designing biologically active peptides. | en_HK |
dc.language | eng | en_US |
dc.publisher | Wiley - V C H Verlag GmbH & Co. KGaA. The Journal's web site is located at http://www.wiley-vch.de/publish/en/journals/alphabeticIndex/2451 | en_HK |
dc.relation.ispartof | Chemistry - An Asian Journal | en_HK |
dc.subject | Circular dichroism | en_HK |
dc.subject | Conformation analysis | en_HK |
dc.subject | Gelical structures | en_HK |
dc.subject | Hydrogen bonds | en_HK |
dc.subject | Peptides | en_HK |
dc.subject.mesh | Acids - Chemistry | en_US |
dc.subject.mesh | Amino Acids - Chemistry | en_US |
dc.subject.mesh | Circular Dichroism | en_US |
dc.subject.mesh | Crystallography, X-Ray | en_US |
dc.subject.mesh | Hydrogen Bonding | en_US |
dc.subject.mesh | Nuclear Magnetic Resonance, Biomolecular | en_US |
dc.subject.mesh | Oligopeptides - Chemistry | en_US |
dc.subject.mesh | Protein Structure, Secondary | en_US |
dc.subject.mesh | Spectroscopy, Fourier Transform Infrared | en_US |
dc.title | Conformational studies on peptides of α-aminoxy acids with functionalized side-chains | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Yang, D: yangdan@hku.hk | en_HK |
dc.identifier.email | Zhu, NY: nzhu@hkucc.hku.hk | en_HK |
dc.identifier.authority | Yang, D=rp00825 | en_HK |
dc.identifier.authority | Zhu, NY=rp00845 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1002/asia.200900636 | en_HK |
dc.identifier.pmid | 20408163 | - |
dc.identifier.scopus | eid_2-s2.0-77952909043 | en_HK |
dc.identifier.hkuros | 180944 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-77952909043&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 5 | en_HK |
dc.identifier.issue | 6 | en_HK |
dc.identifier.spage | 1356 | en_HK |
dc.identifier.epage | 1363 | en_HK |
dc.identifier.isi | WOS:000278840200014 | - |
dc.publisher.place | Germany | en_HK |
dc.identifier.scopusauthorid | Yang, D=7404800756 | en_HK |
dc.identifier.scopusauthorid | Liu, GJ=25823290000 | en_HK |
dc.identifier.scopusauthorid | Hao, Y=7201593182 | en_HK |
dc.identifier.scopusauthorid | Li, W=36064044700 | en_HK |
dc.identifier.scopusauthorid | Dong, ZM=7402274471 | en_HK |
dc.identifier.scopusauthorid | Zhang, DW=35320759400 | en_HK |
dc.identifier.scopusauthorid | Zhu, NY=7201449530 | en_HK |
dc.identifier.issnl | 1861-471X | - |