File Download
There are no files associated with this item.
Links for fulltext
(May Require Subscription)
- Publisher Website: 10.1021/ol1003109
- Scopus: eid_2-s2.0-77951174297
- PMID: 20232847
- WOS: WOS:000276562600020
- Find via
Supplementary
- Citations:
- Appears in Collections:
Article: Salicylaldehyde ester-induced chemoselective peptide ligations: Enabling generation of natural peptidic linkages at the serine/threonine sites
Title | Salicylaldehyde ester-induced chemoselective peptide ligations: Enabling generation of natural peptidic linkages at the serine/threonine sites |
---|---|
Authors | |
Issue Date | 2010 |
Publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/orlef7/index.html |
Citation | Organic Letters, 2010, v. 12 n. 8, p. 1724-1727 How to Cite? |
Abstract | A serine/threonine-based chemoselective ligation method is described. It uses an O-salicylaldehyde ester at the C-terminus, reacting with N-terminal serine or threonine to realize peptide ligations. The utility of the O-salicylaldehyde ester enables the rapid coupling reaction and the production of an N,O-benzylidene acetal intermediate, which is readily converted into natural peptidic linkages (Xaa-Ser/Thr) at the ligation site. © 2010 American Chemical Society. |
Persistent Identifier | http://hdl.handle.net/10722/168451 |
ISSN | 2021 Impact Factor: 6.072 2020 SCImago Journal Rankings: 1.940 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Li, X | en_US |
dc.contributor.author | Lam, HY | en_US |
dc.contributor.author | Zhang, Y | en_US |
dc.contributor.author | Chan, CK | en_US |
dc.date.accessioned | 2012-10-08T03:19:04Z | - |
dc.date.available | 2012-10-08T03:19:04Z | - |
dc.date.issued | 2010 | en_US |
dc.identifier.citation | Organic Letters, 2010, v. 12 n. 8, p. 1724-1727 | en_US |
dc.identifier.issn | 1523-7060 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/168451 | - |
dc.description.abstract | A serine/threonine-based chemoselective ligation method is described. It uses an O-salicylaldehyde ester at the C-terminus, reacting with N-terminal serine or threonine to realize peptide ligations. The utility of the O-salicylaldehyde ester enables the rapid coupling reaction and the production of an N,O-benzylidene acetal intermediate, which is readily converted into natural peptidic linkages (Xaa-Ser/Thr) at the ligation site. © 2010 American Chemical Society. | en_US |
dc.language | eng | en_US |
dc.publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/orlef7/index.html | en_US |
dc.relation.ispartof | Organic Letters | en_US |
dc.subject.mesh | Aldehydes - Chemistry | en_US |
dc.subject.mesh | Catalysis | en_US |
dc.subject.mesh | Peptides - Chemistry | en_US |
dc.subject.mesh | Serine - Chemistry | en_US |
dc.subject.mesh | Substrate Specificity | en_US |
dc.subject.mesh | Threonine - Chemistry | en_US |
dc.title | Salicylaldehyde ester-induced chemoselective peptide ligations: Enabling generation of natural peptidic linkages at the serine/threonine sites | en_US |
dc.type | Article | en_US |
dc.identifier.email | Li, X:xuechenl@hku.hk | en_US |
dc.identifier.authority | Li, X=rp00742 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1021/ol1003109 | en_US |
dc.identifier.pmid | 20232847 | - |
dc.identifier.scopus | eid_2-s2.0-77951174297 | en_US |
dc.identifier.hkuros | 172095 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-77951174297&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 12 | en_US |
dc.identifier.issue | 8 | en_US |
dc.identifier.spage | 1724 | en_US |
dc.identifier.epage | 1727 | en_US |
dc.identifier.eissn | 1523-7052 | - |
dc.identifier.isi | WOS:000276562600020 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Li, X=24168958800 | en_US |
dc.identifier.scopusauthorid | Lam, HY=36196915400 | en_US |
dc.identifier.scopusauthorid | Zhang, Y=36197722200 | en_US |
dc.identifier.scopusauthorid | Chan, CK=36984595500 | en_US |
dc.identifier.issnl | 1523-7052 | - |