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- Publisher Website: 10.1007/s11426-009-0144-6
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Article: Metallomics: An integrated biometal science
Title | Metallomics: An integrated biometal science |
---|---|
Authors | |
Keywords | Chemical Speciation Metallodrug Metallome Metallomics Metalloprotein |
Issue Date | 2009 |
Publisher | Science in China Press. The Journal's web site is located at http://219.238.6.200/journal?code=04 |
Citation | Science In China, Series B: Chemistry, 2009, v. 52 n. 12, p. 2055-2070 How to Cite? |
Abstract | Metallomics is an emerging scientific area integrating the research fields related to the understanding of the molecular mechanisms of metal-associated life processes and the entirety of metal and metalloid species within a cell or tissue type. In metallomics, metalloproteins, metalloenzymes and other metal-containing biomolecules in a biological system are referred to as metallomes, similar to genomes and proteomes in genomics and proteomics, respectively. This review discusses the concept of metallomics with a focus on analytical techniques and methods, particularly the so-called hyphenated techniques which combine a high-resolution separation technique (gel electrophoresis/laser ablation, chromatography or capillary electrophoresis) with a highly sensitive detection method such as elemental (inductively coupled plasma, ICP) or molecular (electron spray ionization (ESI) or matrix-assisted laser desorption/ionization (MALDI)) mass spectrometry, or nuclear X-ray fluorescence/absorption spectrometry. The applications of these advanced analytical methods in the identification of metallo-/phospho-/seleno-proteins, probing of relationships between structure and function of metalloproteins, and study of clinically used metallodrugs will be selectively outlined, along with their advantages and limitations. © 2009 Science in China Press and Springer Berlin Heidelberg. |
Persistent Identifier | http://hdl.handle.net/10722/168431 |
ISSN | 2011 Impact Factor: 1.199 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Ge, R | en_US |
dc.contributor.author | Sun, H | en_US |
dc.date.accessioned | 2012-10-08T03:18:51Z | - |
dc.date.available | 2012-10-08T03:18:51Z | - |
dc.date.issued | 2009 | en_US |
dc.identifier.citation | Science In China, Series B: Chemistry, 2009, v. 52 n. 12, p. 2055-2070 | en_US |
dc.identifier.issn | 1006-9291 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/168431 | - |
dc.description.abstract | Metallomics is an emerging scientific area integrating the research fields related to the understanding of the molecular mechanisms of metal-associated life processes and the entirety of metal and metalloid species within a cell or tissue type. In metallomics, metalloproteins, metalloenzymes and other metal-containing biomolecules in a biological system are referred to as metallomes, similar to genomes and proteomes in genomics and proteomics, respectively. This review discusses the concept of metallomics with a focus on analytical techniques and methods, particularly the so-called hyphenated techniques which combine a high-resolution separation technique (gel electrophoresis/laser ablation, chromatography or capillary electrophoresis) with a highly sensitive detection method such as elemental (inductively coupled plasma, ICP) or molecular (electron spray ionization (ESI) or matrix-assisted laser desorption/ionization (MALDI)) mass spectrometry, or nuclear X-ray fluorescence/absorption spectrometry. The applications of these advanced analytical methods in the identification of metallo-/phospho-/seleno-proteins, probing of relationships between structure and function of metalloproteins, and study of clinically used metallodrugs will be selectively outlined, along with their advantages and limitations. © 2009 Science in China Press and Springer Berlin Heidelberg. | en_US |
dc.language | eng | en_US |
dc.publisher | Science in China Press. The Journal's web site is located at http://219.238.6.200/journal?code=04 | en_US |
dc.relation.ispartof | Science in China, Series B: Chemistry | en_US |
dc.subject | Chemical Speciation | en_US |
dc.subject | Metallodrug | en_US |
dc.subject | Metallome | en_US |
dc.subject | Metallomics | en_US |
dc.subject | Metalloprotein | en_US |
dc.title | Metallomics: An integrated biometal science | en_US |
dc.type | Article | en_US |
dc.identifier.email | Sun, H:hsun@hkucc.hku.hk | en_US |
dc.identifier.authority | Sun, H=rp00777 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1007/s11426-009-0144-6 | en_US |
dc.identifier.scopus | eid_2-s2.0-75749115160 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-75749115160&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 52 | en_US |
dc.identifier.issue | 12 | en_US |
dc.identifier.spage | 2055 | en_US |
dc.identifier.epage | 2070 | en_US |
dc.identifier.isi | WOS:000272917200006 | - |
dc.publisher.place | China | en_US |
dc.identifier.scopusauthorid | Ge, R=7005525090 | en_US |
dc.identifier.scopusauthorid | Sun, H=7404827446 | en_US |
dc.identifier.citeulike | 6445196 | - |
dc.identifier.issnl | 1006-9291 | - |