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- Publisher Website: 10.1016/j.jinorgbio.2009.05.004
- Scopus: eid_2-s2.0-67449161823
- PMID: 19515424
- WOS: WOS:000267768200018
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Article: Iron depletion decreases proliferation and induces apoptosis in a human colonic adenocarcinoma cell line, Caco2
Title | Iron depletion decreases proliferation and induces apoptosis in a human colonic adenocarcinoma cell line, Caco2 |
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Authors | |
Keywords | Anti-proliferation Apoptosis Caco2 cell Desferrioxamine Mitochondria |
Issue Date | 2009 |
Publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jinorgbio |
Citation | Journal Of Inorganic Biochemistry, 2009, v. 103 n. 7, p. 1074-1081 How to Cite? |
Abstract | Iron is essential for maintaining cellular metabolism of most organisms. Iron chelators such as desferrioxamine have been used clinically in the treatment of iron overload diseases. In the present study, we used human colon adenocarcinoma cells as a proliferating cell model to validate that desferrioxamine inhibits cell proliferation and induces apoptosis. Proteomic analysis revealed that proteins involved in cell proliferation, signal transduction, metabolism and protein synthesis were significantly regulated by the availability of iron, rendering a close correlation between cell apoptosis and the disturbance of mitochondrial, signaling and metabolic pathways. These results provide new insights into the mechanisms of cell proliferation inhibition attributed to iron depletion. © 2009 Elsevier Inc. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/168384 |
ISSN | 2023 Impact Factor: 3.8 2023 SCImago Journal Rankings: 0.614 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Sun, X | en_US |
dc.contributor.author | Ge, R | en_US |
dc.contributor.author | Cai, Z | en_US |
dc.contributor.author | Sun, H | en_US |
dc.contributor.author | He, QY | en_US |
dc.date.accessioned | 2012-10-08T03:18:15Z | - |
dc.date.available | 2012-10-08T03:18:15Z | - |
dc.date.issued | 2009 | en_US |
dc.identifier.citation | Journal Of Inorganic Biochemistry, 2009, v. 103 n. 7, p. 1074-1081 | en_US |
dc.identifier.issn | 0162-0134 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/168384 | - |
dc.description.abstract | Iron is essential for maintaining cellular metabolism of most organisms. Iron chelators such as desferrioxamine have been used clinically in the treatment of iron overload diseases. In the present study, we used human colon adenocarcinoma cells as a proliferating cell model to validate that desferrioxamine inhibits cell proliferation and induces apoptosis. Proteomic analysis revealed that proteins involved in cell proliferation, signal transduction, metabolism and protein synthesis were significantly regulated by the availability of iron, rendering a close correlation between cell apoptosis and the disturbance of mitochondrial, signaling and metabolic pathways. These results provide new insights into the mechanisms of cell proliferation inhibition attributed to iron depletion. © 2009 Elsevier Inc. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Elsevier Inc. The Journal's web site is located at http://www.elsevier.com/locate/jinorgbio | en_US |
dc.relation.ispartof | Journal of Inorganic Biochemistry | en_US |
dc.subject | Anti-proliferation | - |
dc.subject | Apoptosis | - |
dc.subject | Caco2 cell | - |
dc.subject | Desferrioxamine | - |
dc.subject | Mitochondria | - |
dc.subject.mesh | Apoptosis | en_US |
dc.subject.mesh | Caco-2 Cells | en_US |
dc.subject.mesh | Cell Proliferation - Drug Effects | en_US |
dc.subject.mesh | Deferoxamine - Pharmacology | en_US |
dc.subject.mesh | Down-Regulation | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Iron - Deficiency - Metabolism | en_US |
dc.subject.mesh | Iron Chelating Agents - Pharmacology | en_US |
dc.subject.mesh | Membrane Potential, Mitochondrial - Drug Effects | en_US |
dc.subject.mesh | Proteome - Drug Effects | en_US |
dc.subject.mesh | Siderophores - Pharmacology | en_US |
dc.subject.mesh | Up-Regulation | en_US |
dc.title | Iron depletion decreases proliferation and induces apoptosis in a human colonic adenocarcinoma cell line, Caco2 | en_US |
dc.type | Article | en_US |
dc.identifier.email | Sun, H:hsun@hkucc.hku.hk | en_US |
dc.identifier.authority | Sun, H=rp00777 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.jinorgbio.2009.05.004 | en_US |
dc.identifier.pmid | 19515424 | - |
dc.identifier.scopus | eid_2-s2.0-67449161823 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-67449161823&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 103 | en_US |
dc.identifier.issue | 7 | en_US |
dc.identifier.spage | 1074 | en_US |
dc.identifier.epage | 1081 | en_US |
dc.identifier.isi | WOS:000267768200018 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Sun, X=35799316500 | en_US |
dc.identifier.scopusauthorid | Ge, R=7005525090 | en_US |
dc.identifier.scopusauthorid | Cai, Z=7402904946 | en_US |
dc.identifier.scopusauthorid | Sun, H=7404827446 | en_US |
dc.identifier.scopusauthorid | He, QY=34770287900 | en_US |
dc.identifier.citeulike | 5344365 | - |
dc.identifier.issnl | 0162-0134 | - |