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- Publisher Website: 10.1016/j.bbrc.2008.12.169
- Scopus: eid_2-s2.0-60349094358
- PMID: 19135980
- WOS: WOS:000263742200001
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Article: MicroRNA-15b regulates cell cycle progression by targeting cyclins in glioma cells
Title | MicroRNA-15b regulates cell cycle progression by targeting cyclins in glioma cells |
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Authors | |
Keywords | CCNE1 Cell cycle Glioblastoma MicroRNA MiR-15b |
Issue Date | 2009 |
Publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description |
Citation | Biochemical And Biophysical Research Communications, 2009, v. 380 n. 2, p. 205-210 How to Cite? |
Abstract | MicroRNAs (miRNAs) are non-protein-coding RNAs that function as post-transcriptional gene regulators. Recent evidence has shown that miRNA plays a pivotal role in the development of many cancers including glioma, a lethal brain cancer. We have recently compared the miRNA expression profiles between normal brain and glioma tissues from Chinese patients by miRNA microarray and identified a panel of differentially expressed miRNAs. Here, we studied the function of one miRNA, miR-15b, in glioma carcinogenesis and elucidated its downstream targets. Over-expression of miR-15b resulted in cell cycle arrest at G0/G1 phase while suppression of miR-15b expression resulted in a decrease of cell populations in G0/G1 and a corresponding increase of cell populations in S phase. We further showed that CCNE1 (encoding cyclin E1) is one of the downstream targets of miR-15b. Taken together, our findings indicate that miR-15b regulates cell cycle progression in glioma cells by targeting cell cycle-related molecules. © 2009 Elsevier Inc. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/168360 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 0.770 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Xia, H | en_HK |
dc.contributor.author | Qi, Y | en_HK |
dc.contributor.author | Ng, SS | en_HK |
dc.contributor.author | Chen, X | en_HK |
dc.contributor.author | Chen, S | en_HK |
dc.contributor.author | Fang, M | en_HK |
dc.contributor.author | Li, D | en_HK |
dc.contributor.author | Zhao, Y | en_HK |
dc.contributor.author | Ge, R | en_HK |
dc.contributor.author | Li, G | en_HK |
dc.contributor.author | Chen, Y | en_HK |
dc.contributor.author | He, ML | en_HK |
dc.contributor.author | Kung, Hf | en_HK |
dc.contributor.author | Lai, L | en_HK |
dc.contributor.author | Lin, MC | en_HK |
dc.date.accessioned | 2012-10-08T03:17:59Z | - |
dc.date.available | 2012-10-08T03:17:59Z | - |
dc.date.issued | 2009 | en_HK |
dc.identifier.citation | Biochemical And Biophysical Research Communications, 2009, v. 380 n. 2, p. 205-210 | en_HK |
dc.identifier.issn | 0006-291X | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/168360 | - |
dc.description.abstract | MicroRNAs (miRNAs) are non-protein-coding RNAs that function as post-transcriptional gene regulators. Recent evidence has shown that miRNA plays a pivotal role in the development of many cancers including glioma, a lethal brain cancer. We have recently compared the miRNA expression profiles between normal brain and glioma tissues from Chinese patients by miRNA microarray and identified a panel of differentially expressed miRNAs. Here, we studied the function of one miRNA, miR-15b, in glioma carcinogenesis and elucidated its downstream targets. Over-expression of miR-15b resulted in cell cycle arrest at G0/G1 phase while suppression of miR-15b expression resulted in a decrease of cell populations in G0/G1 and a corresponding increase of cell populations in S phase. We further showed that CCNE1 (encoding cyclin E1) is one of the downstream targets of miR-15b. Taken together, our findings indicate that miR-15b regulates cell cycle progression in glioma cells by targeting cell cycle-related molecules. © 2009 Elsevier Inc. All rights reserved. | en_HK |
dc.language | eng | en_US |
dc.publisher | Academic Press. The Journal's web site is located at http://www.elsevier.com/wps/find/journaldescription.cws_home/622790/description | en_HK |
dc.relation.ispartof | Biochemical and Biophysical Research Communications | en_HK |
dc.subject | CCNE1 | en_HK |
dc.subject | Cell cycle | en_HK |
dc.subject | Glioblastoma | en_HK |
dc.subject | MicroRNA | en_HK |
dc.subject | MiR-15b | en_HK |
dc.subject.mesh | Brain - Metabolism - Pathology | en_US |
dc.subject.mesh | Brain Neoplasms - Genetics - Pathology | en_US |
dc.subject.mesh | Cell Cycle - Genetics | en_US |
dc.subject.mesh | Cell Line, Tumor | en_US |
dc.subject.mesh | Cell Transformation, Neoplastic - Genetics - Pathology | en_US |
dc.subject.mesh | Cyclins - Genetics | en_US |
dc.subject.mesh | Gene Expression Regulation, Neoplastic | en_US |
dc.subject.mesh | Glioma - Genetics - Pathology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Micrornas - Genetics - Metabolism | en_US |
dc.title | MicroRNA-15b regulates cell cycle progression by targeting cyclins in glioma cells | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Ng, SS: ssmng@hku.hk | en_HK |
dc.identifier.email | Lin, MC: mcllin@hkucc.hku.hk | en_HK |
dc.identifier.authority | Ng, SS=rp00767 | en_HK |
dc.identifier.authority | Lin, MC=rp00746 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.bbrc.2008.12.169 | en_HK |
dc.identifier.pmid | 19135980 | - |
dc.identifier.scopus | eid_2-s2.0-60349094358 | en_HK |
dc.identifier.hkuros | 154237 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-60349094358&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 380 | en_HK |
dc.identifier.issue | 2 | en_HK |
dc.identifier.spage | 205 | en_HK |
dc.identifier.epage | 210 | en_HK |
dc.identifier.isi | WOS:000263742200001 | - |
dc.publisher.place | United States | en_HK |
dc.identifier.scopusauthorid | Xia, H=12545165300 | en_HK |
dc.identifier.scopusauthorid | Qi, Y=24171887800 | en_HK |
dc.identifier.scopusauthorid | Ng, SS=7403358718 | en_HK |
dc.identifier.scopusauthorid | Chen, X=24170717900 | en_HK |
dc.identifier.scopusauthorid | Chen, S=15757054600 | en_HK |
dc.identifier.scopusauthorid | Fang, M=8664493500 | en_HK |
dc.identifier.scopusauthorid | Li, D=26324923700 | en_HK |
dc.identifier.scopusauthorid | Zhao, Y=7406634118 | en_HK |
dc.identifier.scopusauthorid | Ge, R=7005525090 | en_HK |
dc.identifier.scopusauthorid | Li, G=7407055832 | en_HK |
dc.identifier.scopusauthorid | Chen, Y=24075600300 | en_HK |
dc.identifier.scopusauthorid | He, ML=35080389700 | en_HK |
dc.identifier.scopusauthorid | Kung, Hf=7402514190 | en_HK |
dc.identifier.scopusauthorid | Lai, L=12445800200 | en_HK |
dc.identifier.scopusauthorid | Lin, MC=7404816359 | en_HK |
dc.identifier.citeulike | 3886186 | - |
dc.identifier.issnl | 0006-291X | - |