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- Publisher Website: 10.1016/j.bmcl.2007.11.054
- Scopus: eid_2-s2.0-38349057944
- PMID: 18077159
- WOS: WOS:000253410100050
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Article: Structural analogs of tylophora alkaloids may not be functional analogs
Title | Structural analogs of tylophora alkaloids may not be functional analogs |
---|---|
Authors | |
Keywords | Protein, DNA, and RNA synthesis Structure-activity relationship Tylophora alkaloids |
Issue Date | 2008 |
Publisher | Pergamon. The Journal's web site is located at http://www.elsevier.com/locate/bmcl |
Citation | Bioorganic And Medicinal Chemistry Letters, 2008, v. 18 n. 2, p. 704-709 How to Cite? |
Abstract | Phenanthroindolizidine-based tylophora alkaloids have been reported to have potential antitumor, anti-immuno and, anti-inflammatory activity. The structure-activity relationships of a series of tylophora alkaloids were studied to guide future drug design. Our results indicate that although these compounds are structural analogs, their potency of cytotoxicity, selectivity against NF-κB signaling pathway, and their inhibitory effects against protein and nucleic acid synthesis are different. Because they do not have an identical spectrum of targets, the studied compounds are structural, but may not be functional analogs. © 2007 Elsevier Ltd. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/168271 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 0.508 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gao, W | en_US |
dc.contributor.author | Chen, APC | en_US |
dc.contributor.author | Leung, CH | en_US |
dc.contributor.author | Gullen, EA | en_US |
dc.contributor.author | Fürstner, A | en_US |
dc.contributor.author | Shi, Q | en_US |
dc.contributor.author | Wei, L | en_US |
dc.contributor.author | Lee, KH | en_US |
dc.contributor.author | Cheng, YC | en_US |
dc.date.accessioned | 2012-10-08T03:16:54Z | - |
dc.date.available | 2012-10-08T03:16:54Z | - |
dc.date.issued | 2008 | en_US |
dc.identifier.citation | Bioorganic And Medicinal Chemistry Letters, 2008, v. 18 n. 2, p. 704-709 | en_US |
dc.identifier.issn | 0960-894X | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/168271 | - |
dc.description.abstract | Phenanthroindolizidine-based tylophora alkaloids have been reported to have potential antitumor, anti-immuno and, anti-inflammatory activity. The structure-activity relationships of a series of tylophora alkaloids were studied to guide future drug design. Our results indicate that although these compounds are structural analogs, their potency of cytotoxicity, selectivity against NF-κB signaling pathway, and their inhibitory effects against protein and nucleic acid synthesis are different. Because they do not have an identical spectrum of targets, the studied compounds are structural, but may not be functional analogs. © 2007 Elsevier Ltd. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Pergamon. The Journal's web site is located at http://www.elsevier.com/locate/bmcl | en_US |
dc.relation.ispartof | Bioorganic and Medicinal Chemistry Letters | en_US |
dc.subject | Protein, DNA, and RNA synthesis | - |
dc.subject | Structure-activity relationship | - |
dc.subject | Tylophora alkaloids | - |
dc.subject.mesh | Alkaloids - Chemistry - Pharmacology | en_US |
dc.subject.mesh | Cell Line | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Signal Transduction | en_US |
dc.subject.mesh | Structure-Activity Relationship | en_US |
dc.subject.mesh | Tylophora - Chemistry | en_US |
dc.title | Structural analogs of tylophora alkaloids may not be functional analogs | en_US |
dc.type | Article | en_US |
dc.identifier.email | Leung, CH:duncanl@hkucc.hku.hk | en_US |
dc.identifier.authority | Leung, CH=rp00730 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.bmcl.2007.11.054 | en_US |
dc.identifier.pmid | 18077159 | - |
dc.identifier.scopus | eid_2-s2.0-38349057944 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-38349057944&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 18 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.spage | 704 | en_US |
dc.identifier.epage | 709 | en_US |
dc.identifier.isi | WOS:000253410100050 | - |
dc.publisher.place | United Kingdom | en_US |
dc.identifier.scopusauthorid | Gao, W=7402758247 | en_US |
dc.identifier.scopusauthorid | Chen, APC=36984992200 | en_US |
dc.identifier.scopusauthorid | Leung, CH=7402612570 | en_US |
dc.identifier.scopusauthorid | Gullen, EA=6602138704 | en_US |
dc.identifier.scopusauthorid | Fürstner, A=7006374153 | en_US |
dc.identifier.scopusauthorid | Shi, Q=7402698456 | en_US |
dc.identifier.scopusauthorid | Wei, L=35075256300 | en_US |
dc.identifier.scopusauthorid | Lee, KH=35450969800 | en_US |
dc.identifier.scopusauthorid | Cheng, YC=36041844200 | en_US |
dc.identifier.issnl | 0960-894X | - |