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- Publisher Website: 10.1016/j.phymed.2006.03.004
- Scopus: eid_2-s2.0-33846397852
- PMID: 16713217
- WOS: WOS:000244975200012
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Article: Reversal of multidrug resistance in cancer cells by Rhizoma Alismatis extract
Title | Reversal of multidrug resistance in cancer cells by Rhizoma Alismatis extract |
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Authors | |
Keywords | HepG2-DR cells K562-DR cells Multidrug resistance P-glycoprotein Rhizoma Alismatis |
Issue Date | 2007 |
Publisher | Urban und Fischer Verlag. The Journal's web site is located at http://www.elsevier.com/locate/phytomed |
Citation | Phytomedicine, 2007, v. 14 n. 2-3, p. 160-165 How to Cite? |
Abstract | Prolonged chemotherapy may lead to the selective proliferation of multidrug resistant (MDR) cancer cells. In MDR HepG2-DR and K562-DR cells that over-expressed P-glycoprotein (Pgp), the extract of the rhizomes of Alisma orientalis (Sam) Juzep. showed a synergistic growth inhibitory effect with cancer drugs that are Pgp substrates including actinomycin D, puromycin, paclitaxel, vinblastine and doxorubicin. At the same toxicity levels the herbal extract was more effective than verapamil, a standard Pgp inhibitor, in enhancing cellular doxorubicin accumulation and preventing the efflux of rhodamin-123 from the MDR cells. The extract restored the effect of vinblastine on the induction of G 2/M arrest in MDR cells. Our data suggest that A. orientalis may contain components that are effective inhibitors of Pgp. © 2006 Elsevier GmbH. All rights reserved. |
Persistent Identifier | http://hdl.handle.net/10722/168092 |
ISSN | 2023 Impact Factor: 6.7 2023 SCImago Journal Rankings: 1.267 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Fong, WF | en_US |
dc.contributor.author | Wang, C | en_US |
dc.contributor.author | Zhu, GY | en_US |
dc.contributor.author | Leung, CH | en_US |
dc.contributor.author | Yang, MS | en_US |
dc.contributor.author | Cheung, HY | en_US |
dc.date.accessioned | 2012-10-08T03:14:58Z | - |
dc.date.available | 2012-10-08T03:14:58Z | - |
dc.date.issued | 2007 | en_US |
dc.identifier.citation | Phytomedicine, 2007, v. 14 n. 2-3, p. 160-165 | en_US |
dc.identifier.issn | 0944-7113 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/168092 | - |
dc.description.abstract | Prolonged chemotherapy may lead to the selective proliferation of multidrug resistant (MDR) cancer cells. In MDR HepG2-DR and K562-DR cells that over-expressed P-glycoprotein (Pgp), the extract of the rhizomes of Alisma orientalis (Sam) Juzep. showed a synergistic growth inhibitory effect with cancer drugs that are Pgp substrates including actinomycin D, puromycin, paclitaxel, vinblastine and doxorubicin. At the same toxicity levels the herbal extract was more effective than verapamil, a standard Pgp inhibitor, in enhancing cellular doxorubicin accumulation and preventing the efflux of rhodamin-123 from the MDR cells. The extract restored the effect of vinblastine on the induction of G 2/M arrest in MDR cells. Our data suggest that A. orientalis may contain components that are effective inhibitors of Pgp. © 2006 Elsevier GmbH. All rights reserved. | en_US |
dc.language | eng | en_US |
dc.publisher | Urban und Fischer Verlag. The Journal's web site is located at http://www.elsevier.com/locate/phytomed | en_US |
dc.relation.ispartof | Phytomedicine | en_US |
dc.subject | HepG2-DR cells | - |
dc.subject | K562-DR cells | - |
dc.subject | Multidrug resistance | - |
dc.subject | P-glycoprotein | - |
dc.subject | Rhizoma Alismatis | - |
dc.subject.mesh | Alisma | en_US |
dc.subject.mesh | Antineoplastic Agents - Administration & Dosage - Pharmacology - Therapeutic Use | en_US |
dc.subject.mesh | Cell Line, Tumor - Drug Effects - Metabolism | en_US |
dc.subject.mesh | Drug Resistance, Multiple - Drug Effects | en_US |
dc.subject.mesh | Drug Resistance, Neoplasm - Drug Effects | en_US |
dc.subject.mesh | Drug Synergism | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Inhibitory Concentration 50 | en_US |
dc.subject.mesh | P-Glycoprotein - Metabolism | en_US |
dc.subject.mesh | Phytotherapy | en_US |
dc.subject.mesh | Plant Extracts - Administration & Dosage - Pharmacology - Therapeutic Use | en_US |
dc.title | Reversal of multidrug resistance in cancer cells by Rhizoma Alismatis extract | en_US |
dc.type | Article | en_US |
dc.identifier.email | Leung, CH:duncanl@hkucc.hku.hk | en_US |
dc.identifier.authority | Leung, CH=rp00730 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1016/j.phymed.2006.03.004 | en_US |
dc.identifier.pmid | 16713217 | - |
dc.identifier.scopus | eid_2-s2.0-33846397852 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-33846397852&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 14 | en_US |
dc.identifier.issue | 2-3 | en_US |
dc.identifier.spage | 160 | en_US |
dc.identifier.epage | 165 | en_US |
dc.identifier.isi | WOS:000244975200012 | - |
dc.publisher.place | Germany | en_US |
dc.identifier.scopusauthorid | Fong, WF=7102816013 | en_US |
dc.identifier.scopusauthorid | Wang, C=35220849500 | en_US |
dc.identifier.scopusauthorid | Zhu, GY=7402633140 | en_US |
dc.identifier.scopusauthorid | Leung, CH=7402612570 | en_US |
dc.identifier.scopusauthorid | Yang, MS=7404925734 | en_US |
dc.identifier.scopusauthorid | Cheung, HY=7201839371 | en_US |
dc.identifier.issnl | 0944-7113 | - |