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- Publisher Website: 10.1021/ol027458l
- Scopus: eid_2-s2.0-0038345084
- PMID: 12583763
- WOS: WOS:000181077200040
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Article: Synthesis of a carbohydrate-derived hydroxamic acid inhibitor of the bacterial enzyme (LpxC) involved in lipid A biosynthesis
Title | Synthesis of a carbohydrate-derived hydroxamic acid inhibitor of the bacterial enzyme (LpxC) involved in lipid A biosynthesis |
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Authors | |
Issue Date | 2003 |
Publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/orlef7/index.html |
Citation | Organic Letters, 2003, v. 5 n. 4, p. 539-541 How to Cite? |
Abstract | (Matrix presented) The enzyme LpxC (UDP-3-O-[(R)-3-hydroxymyristoyl] -GlcNAc deacetylase) catalyzes the second step of lipid A biosynthesis and is essential for bacterial growth. A GlcNAc-derived hydroxamic acid inhibitor 8 of this enzyme was synthesized using two different routes. Compound 8 exhibits activity toward LpxC enzymes from a wider spectrum of bacterial species than any of the previously reported hydroxamic acid inhibitors. |
Persistent Identifier | http://hdl.handle.net/10722/167800 |
ISSN | 2023 Impact Factor: 4.9 2023 SCImago Journal Rankings: 1.245 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Li, X | en_US |
dc.contributor.author | Uchiyama, T | en_US |
dc.contributor.author | Raetz, CRH | en_US |
dc.contributor.author | Hindsgaul, O | en_US |
dc.date.accessioned | 2012-10-08T03:11:46Z | - |
dc.date.available | 2012-10-08T03:11:46Z | - |
dc.date.issued | 2003 | en_US |
dc.identifier.citation | Organic Letters, 2003, v. 5 n. 4, p. 539-541 | en_US |
dc.identifier.issn | 1523-7060 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/167800 | - |
dc.description.abstract | (Matrix presented) The enzyme LpxC (UDP-3-O-[(R)-3-hydroxymyristoyl] -GlcNAc deacetylase) catalyzes the second step of lipid A biosynthesis and is essential for bacterial growth. A GlcNAc-derived hydroxamic acid inhibitor 8 of this enzyme was synthesized using two different routes. Compound 8 exhibits activity toward LpxC enzymes from a wider spectrum of bacterial species than any of the previously reported hydroxamic acid inhibitors. | en_US |
dc.language | eng | en_US |
dc.publisher | American Chemical Society. The Journal's web site is located at http://pubs.acs.org/journals/orlef7/index.html | en_US |
dc.relation.ispartof | Organic Letters | en_US |
dc.subject.mesh | Amidohydrolases - Antagonists & Inhibitors | en_US |
dc.subject.mesh | Carbohydrates - Chemistry | en_US |
dc.subject.mesh | Enzyme Inhibitors - Chemical Synthesis | en_US |
dc.subject.mesh | Escherichia Coli Proteins - Antagonists & Inhibitors | en_US |
dc.subject.mesh | Hydroxamic Acids - Chemical Synthesis - Pharmacology | en_US |
dc.subject.mesh | Lipid A - Antagonists & Inhibitors - Biosynthesis | en_US |
dc.title | Synthesis of a carbohydrate-derived hydroxamic acid inhibitor of the bacterial enzyme (LpxC) involved in lipid A biosynthesis | en_US |
dc.type | Article | en_US |
dc.identifier.email | Li, X:xuechenl@hku.hk | en_US |
dc.identifier.authority | Li, X=rp00742 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1021/ol027458l | en_US |
dc.identifier.pmid | 12583763 | - |
dc.identifier.scopus | eid_2-s2.0-0038345084 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-0038345084&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 5 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.spage | 539 | en_US |
dc.identifier.epage | 541 | en_US |
dc.identifier.isi | WOS:000181077200040 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Li, X=24168958800 | en_US |
dc.identifier.scopusauthorid | Uchiyama, T=7402391378 | en_US |
dc.identifier.scopusauthorid | Raetz, CRH=7102514726 | en_US |
dc.identifier.scopusauthorid | Hindsgaul, O=7102966220 | en_US |
dc.identifier.issnl | 1523-7052 | - |