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Article: The hepatic adenylate cyclase system. III. A mathematical model for the steady state kinetics of catalysis and nucleotide regulation
Title | The hepatic adenylate cyclase system. III. A mathematical model for the steady state kinetics of catalysis and nucleotide regulation |
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Authors | |
Issue Date | 1975 |
Publisher | American Society for Biochemistry and Molecular Biology, Inc. The Journal's web site is located at http://www.jbc.org/ |
Citation | Journal Of Biological Chemistry, 1975, v. 250 n. 11, p. 4253-4260 How to Cite? |
Abstract | A steady state kinetic model for hepatic adenylate cyclase is presented. The activity of the enzyme was assayed in the presence of a range of concentrations of magnesium, adenylylimidodiphosphate, 5' guanylylimidodiphosphate, and in the presence and absence of saturating concentrations of glucagon. The data were tested against proposed models using an iterative least squares curve fitting program and confidence estimates for the model parameters were obtained. |
Persistent Identifier | http://hdl.handle.net/10722/167434 |
ISSN | 2020 Impact Factor: 5.157 2023 SCImago Journal Rankings: 1.766 |
ISI Accession Number ID |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Rendell, M | en_US |
dc.contributor.author | Salomon, Y | en_US |
dc.contributor.author | Lin, MC | en_US |
dc.date.accessioned | 2012-10-08T03:06:55Z | - |
dc.date.available | 2012-10-08T03:06:55Z | - |
dc.date.issued | 1975 | en_US |
dc.identifier.citation | Journal Of Biological Chemistry, 1975, v. 250 n. 11, p. 4253-4260 | en_US |
dc.identifier.issn | 0021-9258 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/167434 | - |
dc.description.abstract | A steady state kinetic model for hepatic adenylate cyclase is presented. The activity of the enzyme was assayed in the presence of a range of concentrations of magnesium, adenylylimidodiphosphate, 5' guanylylimidodiphosphate, and in the presence and absence of saturating concentrations of glucagon. The data were tested against proposed models using an iterative least squares curve fitting program and confidence estimates for the model parameters were obtained. | en_US |
dc.language | eng | en_US |
dc.publisher | American Society for Biochemistry and Molecular Biology, Inc. The Journal's web site is located at http://www.jbc.org/ | en_US |
dc.relation.ispartof | Journal of Biological Chemistry | en_US |
dc.subject.mesh | Adenine Nucleotides - Pharmacology | en_US |
dc.subject.mesh | Adenylate Cyclase - Metabolism | en_US |
dc.subject.mesh | Animals | en_US |
dc.subject.mesh | Binding Sites | en_US |
dc.subject.mesh | Computers | en_US |
dc.subject.mesh | Enzyme Activation - Drug Effects | en_US |
dc.subject.mesh | Glucagon - Pharmacology | en_US |
dc.subject.mesh | Guanine Nucleotides - Pharmacology | en_US |
dc.subject.mesh | Kinetics | en_US |
dc.subject.mesh | Liver - Enzymology | en_US |
dc.subject.mesh | Mathematics | en_US |
dc.subject.mesh | Protein Binding | en_US |
dc.subject.mesh | Rats | en_US |
dc.title | The hepatic adenylate cyclase system. III. A mathematical model for the steady state kinetics of catalysis and nucleotide regulation | en_US |
dc.type | Article | en_US |
dc.identifier.email | Lin, MC:mcllin@hkucc.hku.hk | en_US |
dc.identifier.authority | Lin, MC=rp00746 | en_US |
dc.description.nature | link_to_OA_fulltext | en_US |
dc.identifier.pmid | 1126950 | - |
dc.identifier.scopus | eid_2-s2.0-0016705577 | en_US |
dc.identifier.volume | 250 | en_US |
dc.identifier.issue | 11 | en_US |
dc.identifier.spage | 4253 | en_US |
dc.identifier.epage | 4260 | en_US |
dc.identifier.isi | WOS:A1975AE57800031 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Rendell, M=7006683060 | en_US |
dc.identifier.scopusauthorid | Salomon, Y=7006956498 | en_US |
dc.identifier.scopusauthorid | Lin, MC=7404816359 | en_US |
dc.identifier.issnl | 0021-9258 | - |