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Article: The hepatic adenylate cyclase system. III. A mathematical model for the steady state kinetics of catalysis and nucleotide regulation

TitleThe hepatic adenylate cyclase system. III. A mathematical model for the steady state kinetics of catalysis and nucleotide regulation
Authors
Rendell, MSalomon, YLin, MC
Issue Date1975
PublisherAmerican Society for Biochemistry and Molecular Biology, Inc. The Journal's web site is located at http://www.jbc.org/
Citation
Journal Of Biological Chemistry, 1975, v. 250 n. 11, p. 4253-4260 How to Cite?
AbstractA steady state kinetic model for hepatic adenylate cyclase is presented. The activity of the enzyme was assayed in the presence of a range of concentrations of magnesium, adenylylimidodiphosphate, 5' guanylylimidodiphosphate, and in the presence and absence of saturating concentrations of glucagon. The data were tested against proposed models using an iterative least squares curve fitting program and confidence estimates for the model parameters were obtained.
Persistent Identifierhttp://hdl.handle.net/10722/167434
ISSN
0021-9258
2020 Impact Factor: 5.157
2020 SCImago Journal Rankings: 2.361
ISI Accession Number ID
WOS:A1975AE57800031

 

DC FieldValueLanguage
dc.contributor.authorRendell, Men_US
dc.contributor.authorSalomon, Yen_US
dc.contributor.authorLin, MCen_US
dc.date.accessioned2012-10-08T03:06:55Z-
dc.date.available2012-10-08T03:06:55Z-
dc.date.issued1975en_US
dc.identifier.citationJournal Of Biological Chemistry, 1975, v. 250 n. 11, p. 4253-4260en_US
dc.identifier.issn0021-9258en_US
dc.identifier.urihttp://hdl.handle.net/10722/167434-
dc.description.abstractA steady state kinetic model for hepatic adenylate cyclase is presented. The activity of the enzyme was assayed in the presence of a range of concentrations of magnesium, adenylylimidodiphosphate, 5' guanylylimidodiphosphate, and in the presence and absence of saturating concentrations of glucagon. The data were tested against proposed models using an iterative least squares curve fitting program and confidence estimates for the model parameters were obtained.en_US
dc.languageengen_US
dc.publisherAmerican Society for Biochemistry and Molecular Biology, Inc. The Journal's web site is located at http://www.jbc.org/en_US
dc.relation.ispartofJournal of Biological Chemistryen_US
dc.subject.meshAdenine Nucleotides - Pharmacologyen_US
dc.subject.meshAdenylate Cyclase - Metabolismen_US
dc.subject.meshAnimalsen_US
dc.subject.meshBinding Sitesen_US
dc.subject.meshComputersen_US
dc.subject.meshEnzyme Activation - Drug Effectsen_US
dc.subject.meshGlucagon - Pharmacologyen_US
dc.subject.meshGuanine Nucleotides - Pharmacologyen_US
dc.subject.meshKineticsen_US
dc.subject.meshLiver - Enzymologyen_US
dc.subject.meshMathematicsen_US
dc.subject.meshProtein Bindingen_US
dc.subject.meshRatsen_US
dc.titleThe hepatic adenylate cyclase system. III. A mathematical model for the steady state kinetics of catalysis and nucleotide regulationen_US
dc.typeArticleen_US
dc.identifier.emailLin, MC:mcllin@hkucc.hku.hken_US
dc.identifier.authorityLin, MC=rp00746en_US
dc.description.naturelink_to_OA_fulltexten_US
dc.identifier.pmid1126950-
dc.identifier.scopuseid_2-s2.0-0016705577en_US
dc.identifier.volume250en_US
dc.identifier.issue11en_US
dc.identifier.spage4253en_US
dc.identifier.epage4260en_US
dc.identifier.isiWOS:A1975AE57800031-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridRendell, M=7006683060en_US
dc.identifier.scopusauthoridSalomon, Y=7006956498en_US
dc.identifier.scopusauthoridLin, MC=7404816359en_US
dc.identifier.issnl0021-9258-

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