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- Publisher Website: 10.1007/978-94-007-3027-4_17
- Scopus: eid_2-s2.0-84931340558
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Book Chapter: Mortalin-p53 interaction as a target for liver cancer therapy
Title | Mortalin-p53 interaction as a target for liver cancer therapy |
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Authors | |
Keywords | Cellular stress Hepatocellular carcinoma Mortalin-p53 interaction Targeted therapy |
Issue Date | 2012 |
Publisher | Springer |
Citation | Mortalin-p53 interaction as a target for liver cancer therapy. In Kaul, SC & Wadhwa, R (Eds.), Mortalin Biology: Life, Stress and Death, p. 267-278. Dordrecht ; New York: Springer, 2012 How to Cite? |
Abstract | Mortalin is a member of Hsp70 family that exhibits a tight correlation with carcinogenesis. It has been shown to inactivate tumor suppressor protein p53. The present chapter reviews the history and presents information of mortalin, p53 and how their interaction contributes to carcinogenesis. It is demonstrated that mortalin-p53 interaction that is a cancer-driving event depends on the stress state of cells. The small molecules and short peptides that were able to block this interaction could induce apoptosis in cancer cells that harbour mutant p53 suggesting that mortalin-p53 is a good target for cancer therapy. Understanding of the molecular regulation of mortalin-p53 interaction and their role in highly malignant cells will help designing better strategies for cancer treatment. |
Persistent Identifier | http://hdl.handle.net/10722/166596 |
ISBN |
DC Field | Value | Language |
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dc.contributor.author | Lu, WJ | en_US |
dc.contributor.author | Lee, NPY | en_US |
dc.contributor.author | Wadhwa, R | en_US |
dc.contributor.author | Luk, JMC | en_US |
dc.date.accessioned | 2012-09-20T08:41:56Z | - |
dc.date.available | 2012-09-20T08:41:56Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.citation | Mortalin-p53 interaction as a target for liver cancer therapy. In Kaul, SC & Wadhwa, R (Eds.), Mortalin Biology: Life, Stress and Death, p. 267-278. Dordrecht ; New York: Springer, 2012 | en_US |
dc.identifier.isbn | 9789400730267 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/166596 | - |
dc.description.abstract | Mortalin is a member of Hsp70 family that exhibits a tight correlation with carcinogenesis. It has been shown to inactivate tumor suppressor protein p53. The present chapter reviews the history and presents information of mortalin, p53 and how their interaction contributes to carcinogenesis. It is demonstrated that mortalin-p53 interaction that is a cancer-driving event depends on the stress state of cells. The small molecules and short peptides that were able to block this interaction could induce apoptosis in cancer cells that harbour mutant p53 suggesting that mortalin-p53 is a good target for cancer therapy. Understanding of the molecular regulation of mortalin-p53 interaction and their role in highly malignant cells will help designing better strategies for cancer treatment. | - |
dc.language | eng | en_US |
dc.publisher | Springer | en_US |
dc.relation.ispartof | Mortalin Biology: Life, Stress and Death | en_US |
dc.subject | Cellular stress | - |
dc.subject | Hepatocellular carcinoma | - |
dc.subject | Mortalin-p53 interaction | - |
dc.subject | Targeted therapy | - |
dc.title | Mortalin-p53 interaction as a target for liver cancer therapy | en_US |
dc.type | Book_Chapter | en_US |
dc.identifier.email | Lee, NPY: nikkilee@hku.hk | en_US |
dc.identifier.email | Luk, JMC: jmluk@hku.hk | en_US |
dc.identifier.authority | Lee, NPY=rp00263 | en_US |
dc.identifier.authority | Luk, JMC=rp00349 | en_US |
dc.identifier.doi | 10.1007/978-94-007-3027-4_17 | - |
dc.identifier.scopus | eid_2-s2.0-84931340558 | - |
dc.identifier.hkuros | 211301 | en_US |
dc.identifier.spage | 267 | en_US |
dc.identifier.epage | 278 | en_US |
dc.publisher.place | Dordrecht ; New York | - |