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Conference Paper: Can we possibly derive environmental quality benchmarks for chemical mixtures?
Title | Can we possibly derive environmental quality benchmarks for chemical mixtures? |
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Authors | |
Issue Date | 2012 |
Publisher | SETAC Europe Office. |
Citation | The 6th SETAC World Congress and 22nd Annual Meeting of the Society of Environmental Toxicology and Chemistry (SETAC), Berlin, Germany, 20-24 May 2012. In Abstracts Book, 2012, bk. 2, pt. 2, p. 331, abstract no. TU205 How to Cite? |
Abstract | In reality, many chemical pollutants are indeed coexisting in the aquatic environment. For example, many antifouling biocide residues are often detected as a cocktail in water and sediment samples collected from coastal environments. Based on literature review of documented studies on the combined ecotoxicity of antifouling biocides, we found that both additive and synergistic effects together account for 80% of all cases in which about 35% cases are synergistic. To allow more accurate risk assessment of concurrently occurring chemicals, there is a need to develop environmental quality benchmarks (EQBs) for their mixtures. In this presentation, I will introduce and discuss several possibilities of deriving EQBs for chemical mixtures. First, if all components in a chemical mixture are known to share a similar toxic mode of action, we can assume that the combined toxicity of the mixture would follow a simple concentration addition model, and the concept of toxic equivalency quotient (TEQ) could be applied to derive the EQBs based on lethal and/or effect concentrations expressed in terms of TEQ and/or TEQ concentration. This method has been applied to polychlorinated biphenyls, dioxins and dioxin-like compounds, and chlorinated polycyclic aromatic hydrocarbons. Second, if the mixtures contain chemicals with different toxic modes of action, it is possible to explore the use of the multidimensional species sensitivity distribution (m-SSD) approach. Here, I use binary mixtures of copper (Cu) and zinc pyrithione (ZnPT) as an example to illustrate the m-SSD method. We first conducted standard acute toxicity tests with an array of marine organisms for each chemical alone, and for their mixtures. The Cu-ZnPT mixtures showed a strong synergistic toxic effect to all test organisms. By utilizing all the toxicity data, we are able to construct a two-dimensional SSD in form of a response surface, from which we can derive any specific hazardous concentration (i.e., EQB) for the two compounds. This novel method can be potentially applicable to a more complex mixture by employing non-parametric response surface models. Third, I will highlight the field-based SSD approach, which is integrated with the quantile regression method, can be used to derive sediment quality guidelines for any target chemical with consideration of the presence of chemical mixtures and biological interaction. Finally I will discuss the pros and cons of each described method. |
Description | Poster Presentation: RA20P - Risk assessment of chemical mixtures: where do we stand? what are the next steps?: abstract no. TU205 |
Persistent Identifier | http://hdl.handle.net/10722/166231 |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Leung, MY | en_US |
dc.date.accessioned | 2012-09-20T08:30:33Z | - |
dc.date.available | 2012-09-20T08:30:33Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.citation | The 6th SETAC World Congress and 22nd Annual Meeting of the Society of Environmental Toxicology and Chemistry (SETAC), Berlin, Germany, 20-24 May 2012. In Abstracts Book, 2012, bk. 2, pt. 2, p. 331, abstract no. TU205 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/166231 | - |
dc.description | Poster Presentation: RA20P - Risk assessment of chemical mixtures: where do we stand? what are the next steps?: abstract no. TU205 | - |
dc.description.abstract | In reality, many chemical pollutants are indeed coexisting in the aquatic environment. For example, many antifouling biocide residues are often detected as a cocktail in water and sediment samples collected from coastal environments. Based on literature review of documented studies on the combined ecotoxicity of antifouling biocides, we found that both additive and synergistic effects together account for 80% of all cases in which about 35% cases are synergistic. To allow more accurate risk assessment of concurrently occurring chemicals, there is a need to develop environmental quality benchmarks (EQBs) for their mixtures. In this presentation, I will introduce and discuss several possibilities of deriving EQBs for chemical mixtures. First, if all components in a chemical mixture are known to share a similar toxic mode of action, we can assume that the combined toxicity of the mixture would follow a simple concentration addition model, and the concept of toxic equivalency quotient (TEQ) could be applied to derive the EQBs based on lethal and/or effect concentrations expressed in terms of TEQ and/or TEQ concentration. This method has been applied to polychlorinated biphenyls, dioxins and dioxin-like compounds, and chlorinated polycyclic aromatic hydrocarbons. Second, if the mixtures contain chemicals with different toxic modes of action, it is possible to explore the use of the multidimensional species sensitivity distribution (m-SSD) approach. Here, I use binary mixtures of copper (Cu) and zinc pyrithione (ZnPT) as an example to illustrate the m-SSD method. We first conducted standard acute toxicity tests with an array of marine organisms for each chemical alone, and for their mixtures. The Cu-ZnPT mixtures showed a strong synergistic toxic effect to all test organisms. By utilizing all the toxicity data, we are able to construct a two-dimensional SSD in form of a response surface, from which we can derive any specific hazardous concentration (i.e., EQB) for the two compounds. This novel method can be potentially applicable to a more complex mixture by employing non-parametric response surface models. Third, I will highlight the field-based SSD approach, which is integrated with the quantile regression method, can be used to derive sediment quality guidelines for any target chemical with consideration of the presence of chemical mixtures and biological interaction. Finally I will discuss the pros and cons of each described method. | - |
dc.language | eng | en_US |
dc.publisher | SETAC Europe Office. | - |
dc.relation.ispartof | SETAC World Congress and SETAC Europe Annual Meeting | en_US |
dc.title | Can we possibly derive environmental quality benchmarks for chemical mixtures? | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Leung, MY: kmyleung@hku.hk | en_US |
dc.identifier.authority | Leung, MY=rp00733 | en_US |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.hkuros | 207261 | en_US |
dc.identifier.volume | bk. 2 | - |
dc.identifier.issue | pt. 2 | - |
dc.identifier.spage | 331 | - |
dc.identifier.epage | 331 | - |
dc.publisher.place | Belgium | - |
dc.description.other | The 6th SETAC World Congress and 22nd Annual Meeting of the Society of Environmental Toxicology and Chemistry (SETAC), Berlin, Germany, 20-24 May 2012. In Abstracts Book of the 6th SETAC World Congress/SETAC Europe 22nd Annual Meeting, 2012, bk. 2, pt. 2, p. 331, abstract no. TU205 | - |