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Conference Paper: CDK5-mediated phosphorylation of SIRT1 at serine 47 contributes to the development of endothelial senescence
| Title | CDK5-mediated phosphorylation of SIRT1 at serine 47 contributes to the development of endothelial senescence |
|---|---|
| Authors | |
| Issue Date | 2012 |
| Publisher | International Symposium on Atherosclerosis. |
| Citation | The 16th International Symposium on Atherosclerosis (ISA 2012), Sydney, Australia, 25-29 March 2012. How to Cite? |
| Abstract | BACKGROUND: Senescence of endothelial cells precedes the occurrence of vascular dysfunction and promotes the development of atherosclerosis. SIRT1 is a NAD-dependent deacetylase possessing anti-aging activities. In senescent endothelial cells, both the activity and expression level of SIRT1 are decreased. However, mechanisms underlying this down-regulation of SIRT1 are largely uncharacterized. The present study evaluated the regulation and role of ... |
| Description | ISA 2012 Monday Abstracts Poster Session 1 – Vascular Biology of Atherosclerosis: Poster no. 98: Monday abstract no. 206 |
| Persistent Identifier | http://hdl.handle.net/10722/165626 |
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Bai, B | en_US |
| dc.contributor.author | Vanhoutte, PM | en_US |
| dc.contributor.author | Wang, Y | en_US |
| dc.date.accessioned | 2012-09-20T08:21:21Z | - |
| dc.date.available | 2012-09-20T08:21:21Z | - |
| dc.date.issued | 2012 | en_US |
| dc.identifier.citation | The 16th International Symposium on Atherosclerosis (ISA 2012), Sydney, Australia, 25-29 March 2012. | en_US |
| dc.identifier.uri | http://hdl.handle.net/10722/165626 | - |
| dc.description | ISA 2012 Monday Abstracts | - |
| dc.description | Poster Session 1 – Vascular Biology of Atherosclerosis: Poster no. 98: Monday abstract no. 206 | - |
| dc.description.abstract | BACKGROUND: Senescence of endothelial cells precedes the occurrence of vascular dysfunction and promotes the development of atherosclerosis. SIRT1 is a NAD-dependent deacetylase possessing anti-aging activities. In senescent endothelial cells, both the activity and expression level of SIRT1 are decreased. However, mechanisms underlying this down-regulation of SIRT1 are largely uncharacterized. The present study evaluated the regulation and role of ... | - |
| dc.language | eng | en_US |
| dc.publisher | International Symposium on Atherosclerosis. | - |
| dc.relation.ispartof | International Symposium on Atherosclerosis, ISA 2012 | en_US |
| dc.title | CDK5-mediated phosphorylation of SIRT1 at serine 47 contributes to the development of endothelial senescence | en_US |
| dc.type | Conference_Paper | en_US |
| dc.identifier.email | Bai, B: caveolim@hku.hk | en_US |
| dc.identifier.email | Vanhoutte, PM: vanhoutt@hku.hk | en_US |
| dc.identifier.email | Wang, Y: yuwanghk@hku.hk | - |
| dc.identifier.authority | Vanhoutte, PM=rp00238 | en_US |
| dc.identifier.authority | Wang, Y=rp00239 | en_US |
| dc.description.nature | postprint | - |
| dc.identifier.hkuros | 210639 | en_US |
| dc.identifier.volume | Monday Abstracts | - |
| dc.publisher.place | Australia | - |
| dc.description.other | The 16th International Symposium on Atherosclerosis (ISA2012), Sydney, Australia, 25-29 March 2012. In ISA2012 Monday Abstracts | - |