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Conference Paper: Emulsion electrospinning of nanofibrous delivery vehicles for the controlled release of biomolecules and the in vitro release behaviour of biomolecules
Title | Emulsion electrospinning of nanofibrous delivery vehicles for the controlled release of biomolecules and the in vitro release behaviour of biomolecules |
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Authors | |
Keywords | Controlled-release Core-shell structure Emulsion electrospinning Nano-fiber |
Issue Date | 2011 |
Publisher | Trans Tech Publications Ltd.. The Journal's web site is located at http://www.scitec.ch/1022-6680/ |
Citation | The 20th International Symposium on Processing and Fabrication of Advanced Materials (PFAM 2011), Hong Kong, 15-18 December 2011. In Advanced Materials Research, 2011, v. 410, p. 98-101 How to Cite? |
Abstract | Electrospinning is a popular technique for constructing nanofibrous tissue engineering scaffolds. Electrospinning is also amenable to the incorporation of drugs or biomolecules in fibers, which can provide local and sustained delivery of biological signals, such as growth factors, for the seeded cells. Drugs can normally be dissolved in polymer solutions for electrospinning, forming nanofibrous drug delivery systems. However, simply blending biomolecules in polymer solutions can result in denaturation of biomolecules and large initial burst release. Therefore, emulsion electrospinning, which can provide protection for biomolecules during electrospinning, is of great interest. In this investigation, biomolecule-containing scaffolds were emulsion electrospun using bovine serum albumin (BSA) as the model protein. Two polymers, poly (lactic-co-glycolic acid) and poly (D,L-lactic acid), were used due to their different degradation characteristics. Nanofibers with core-shell structures were electrospun from water-in-oil emulsions formulated by polymer solution, BSA-containing deionized water and a surfactant. By changing the polymer concentration and water phase volume, the fiber diameter and core-shell structure were varied. With different polymers and different fiber structures, the in vitro BSA release behaviours from fibrous scaffolds were different. |
Description | This series vol. has title: Processing and Fabrication of Advanced Materials: selected, peer reviewed papers from the 20th International Symposium on Processing and Fabrication of Advanced Materials (PFAM XX) |
Persistent Identifier | http://hdl.handle.net/10722/165377 |
ISBN | |
ISSN |
DC Field | Value | Language |
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dc.contributor.author | Wang, C | en_US |
dc.contributor.author | Wang, M | en_US |
dc.date.accessioned | 2012-09-20T08:17:47Z | - |
dc.date.available | 2012-09-20T08:17:47Z | - |
dc.date.issued | 2011 | en_US |
dc.identifier.citation | The 20th International Symposium on Processing and Fabrication of Advanced Materials (PFAM 2011), Hong Kong, 15-18 December 2011. In Advanced Materials Research, 2011, v. 410, p. 98-101 | en_US |
dc.identifier.isbn | 978-3-03785-316-0 | - |
dc.identifier.issn | 1022-6680 | - |
dc.identifier.uri | http://hdl.handle.net/10722/165377 | - |
dc.description | This series vol. has title: Processing and Fabrication of Advanced Materials: selected, peer reviewed papers from the 20th International Symposium on Processing and Fabrication of Advanced Materials (PFAM XX) | - |
dc.description.abstract | Electrospinning is a popular technique for constructing nanofibrous tissue engineering scaffolds. Electrospinning is also amenable to the incorporation of drugs or biomolecules in fibers, which can provide local and sustained delivery of biological signals, such as growth factors, for the seeded cells. Drugs can normally be dissolved in polymer solutions for electrospinning, forming nanofibrous drug delivery systems. However, simply blending biomolecules in polymer solutions can result in denaturation of biomolecules and large initial burst release. Therefore, emulsion electrospinning, which can provide protection for biomolecules during electrospinning, is of great interest. In this investigation, biomolecule-containing scaffolds were emulsion electrospun using bovine serum albumin (BSA) as the model protein. Two polymers, poly (lactic-co-glycolic acid) and poly (D,L-lactic acid), were used due to their different degradation characteristics. Nanofibers with core-shell structures were electrospun from water-in-oil emulsions formulated by polymer solution, BSA-containing deionized water and a surfactant. By changing the polymer concentration and water phase volume, the fiber diameter and core-shell structure were varied. With different polymers and different fiber structures, the in vitro BSA release behaviours from fibrous scaffolds were different. | - |
dc.language | eng | en_US |
dc.publisher | Trans Tech Publications Ltd.. The Journal's web site is located at http://www.scitec.ch/1022-6680/ | - |
dc.relation.ispartof | Advanced Materials Research | en_US |
dc.subject | Controlled-release | - |
dc.subject | Core-shell structure | - |
dc.subject | Emulsion electrospinning | - |
dc.subject | Nano-fiber | - |
dc.title | Emulsion electrospinning of nanofibrous delivery vehicles for the controlled release of biomolecules and the in vitro release behaviour of biomolecules | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Wang, C: mecwang@hku.hk | en_US |
dc.identifier.email | Wang, M: memwang@hku.hk | - |
dc.identifier.authority | Wang, M=rp00185 | en_US |
dc.identifier.doi | 10.4028/www.scientific.net/AMR.410.98 | - |
dc.identifier.scopus | eid_2-s2.0-84255195643 | - |
dc.identifier.hkuros | 207475 | en_US |
dc.identifier.hkuros | 207616 | - |
dc.identifier.volume | 410 | - |
dc.identifier.spage | 98 | en_US |
dc.identifier.epage | 101 | en_US |
dc.publisher.place | Switzerland | - |
dc.description.other | The 20th International Symposium on Processing and Fabrication of Advanced Materials (PFAM 2011), Hong Kong, 15-18 December 2011. In Advanced Materials Research, 2011, v. 410, p. 98-101 | - |
dc.identifier.issnl | 1022-6680 | - |