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Conference Paper: Aspirin as an antifungal lock therapy agent
Title | Aspirin as an antifungal lock therapy agent |
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Authors | |
Keywords | Antimicrobial agents/inhibitors Biofilm Fungi Infection and aspirin |
Issue Date | 2011 |
Publisher | International Association for Dental Research. |
Citation | The 25th IADR-SEA Division Annual Scientific Meeting, Singapore, 28-30 October 2011. How to Cite? |
Abstract | Candida biofilms on central venous catheters are one of the commonest nosocomial fungal bloodstream infections. Antifungal lock solutions have been shown to be effective in salvaging indwelling catheters in patients requiring intravenous therapy. Objectives: To determine the activity of aspirin as a lock solution against four Candida biofilms on silicone catheter sections. Methods: Biofilms of Candida albicans, Candida glabrata, Candida krusei and Candida tropicalis were formed on silicone catheters in vitro. The catheters were exposed to lock therapy with aspirin at concentrations of 5 mg/ml – 45 mg/ml, for 2, 4 and 24 hr. Untreated biofilms served as controls. The catheters were then removed and quantified by culture and XTT assays. Results: Significant reduction in CFU counts (approaching 100%) was detected as early as 2 hr in C. albicans biofilms treated with 40 mg/ml aspirin, whereas the same level of reduction was only obtained at 45 mg/ml aspirin, locked for 4 hr in C. glabrata and C. tropicalis (p < 0.05). However, C. krusei only showed 50 % reduction of XTT activities at concentration of 45 mg/ml aspirin, locked for 24 hr. Conclusion: Our results showed that catheter-lock solution of aspirin may be used to salvage catheters infected with C. albicans, C. glabrata, C. tropicalis , but not C. krusei. |
Description | Poster Session - Microbiology/Immunology II: abstract no. 177 Journal of Dental Research, 2011, Special Issue B, p. 177 |
Persistent Identifier | http://hdl.handle.net/10722/164986 |
DC Field | Value | Language |
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dc.contributor.author | Tsang, PCS | en_US |
dc.contributor.author | Tsang, PWK | en_US |
dc.contributor.author | Chan, AKY | en_US |
dc.date.accessioned | 2012-09-20T08:13:15Z | - |
dc.date.available | 2012-09-20T08:13:15Z | - |
dc.date.issued | 2011 | en_US |
dc.identifier.citation | The 25th IADR-SEA Division Annual Scientific Meeting, Singapore, 28-30 October 2011. | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/164986 | - |
dc.description | Poster Session - Microbiology/Immunology II: abstract no. 177 | - |
dc.description | Journal of Dental Research, 2011, Special Issue B, p. 177 | - |
dc.description.abstract | Candida biofilms on central venous catheters are one of the commonest nosocomial fungal bloodstream infections. Antifungal lock solutions have been shown to be effective in salvaging indwelling catheters in patients requiring intravenous therapy. Objectives: To determine the activity of aspirin as a lock solution against four Candida biofilms on silicone catheter sections. Methods: Biofilms of Candida albicans, Candida glabrata, Candida krusei and Candida tropicalis were formed on silicone catheters in vitro. The catheters were exposed to lock therapy with aspirin at concentrations of 5 mg/ml – 45 mg/ml, for 2, 4 and 24 hr. Untreated biofilms served as controls. The catheters were then removed and quantified by culture and XTT assays. Results: Significant reduction in CFU counts (approaching 100%) was detected as early as 2 hr in C. albicans biofilms treated with 40 mg/ml aspirin, whereas the same level of reduction was only obtained at 45 mg/ml aspirin, locked for 4 hr in C. glabrata and C. tropicalis (p < 0.05). However, C. krusei only showed 50 % reduction of XTT activities at concentration of 45 mg/ml aspirin, locked for 24 hr. Conclusion: Our results showed that catheter-lock solution of aspirin may be used to salvage catheters infected with C. albicans, C. glabrata, C. tropicalis , but not C. krusei. | - |
dc.language | eng | en_US |
dc.publisher | International Association for Dental Research. | - |
dc.relation.ispartof | IADR-SEA Division Annual Scientific Meeting, 2011 | en_US |
dc.subject | Antimicrobial agents/inhibitors | - |
dc.subject | Biofilm | - |
dc.subject | Fungi | - |
dc.subject | Infection and aspirin | - |
dc.title | Aspirin as an antifungal lock therapy agent | en_US |
dc.type | Conference_Paper | en_US |
dc.identifier.email | Tsang, PCS: csptsang@hkucc.hku.hk | en_US |
dc.identifier.email | Tsang, PWK: pwktsang@hku.hk | en_US |
dc.identifier.authority | Tsang, PCS=rp00026 | en_US |
dc.identifier.authority | Tsang, PWK=rp01388 | en_US |
dc.description.nature | link_to_OA_fulltext | - |
dc.identifier.hkuros | 197788 | en_US |
dc.identifier.hkuros | 209184 | - |
dc.description.other | The 25th IADR-SEA Division Annual Scientific Meeting, Singapore, 28-30 October 2011. | - |