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Article: Umbilical cord mesenchymal stem cells suppress B-cell proliferation and differentiation

TitleUmbilical cord mesenchymal stem cells suppress B-cell proliferation and differentiation
Authors
Che, NLi, XZhou, SLiu, RShi, DLu, LSun, L
KeywordsB cells
B-cell proliferation and differentiation
Umbilical cord mesenchymal stem cells
Issue Date2012
PublisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ycimm
Citation
Cellular Immunology, 2012, v. 274 n. 1-2, p. 46-53 How to Cite?
DOI: http://dx.doi.org/10.1016/j.cellimm.2012.02.004
AbstractMesenchymal stem cells (MSCs) may be obtained from umbilical cord as an abundant and noninvasive source. However, the immunomodulatory properties of umbilical cord-MSCs (UC-MSCs) were poorly studied. In this study, we aimed to investigate the effects of UC-MSCs on B-cell proliferation and differentiation. UC-MSCs were found to suppress the proliferation of B cells isolated from murine spleen. Moreover, UC-MSCs markedly suppressed B-cell differentiation as shown by the decreased number of CD138+cells and reduced levels of IgM and IgG production in coculture. As revealed by transwell experiments, soluble factors produced by UC-MSCs might be involved in mediating B-cell suppression. The Blimp-1 mRNA expression was suppressed whereas the PAX-5 mRNA expression was induced in coculture. Finally, UC-MSCs modified the phosphorylation pattern of Akt and p38 pathways, which were involved in B-cell proliferation and differentiation. These results may further support the potential therapeutic use of UC-MSCs in treating autoimmune disorders.
Persistent Identifierhttp://hdl.handle.net/10722/164849
ISSN
0008-8749
2021 Impact Factor: 4.178
2020 SCImago Journal Rankings: 1.902
ISI Accession Number ID
WOS:000303694900007

 

DC FieldValueLanguage
dc.contributor.authorChe, N-
dc.contributor.authorLi, X-
dc.contributor.authorZhou, S-
dc.contributor.authorLiu, R-
dc.contributor.authorShi, D-
dc.contributor.authorLu, L-
dc.contributor.authorSun, L-
dc.date.accessioned2012-09-20T08:10:56Z-
dc.date.available2012-09-20T08:10:56Z-
dc.date.issued2012-
dc.identifier.citationCellular Immunology, 2012, v. 274 n. 1-2, p. 46-53-
dc.identifier.issn0008-8749-
dc.identifier.urihttp://hdl.handle.net/10722/164849-
dc.description.abstractMesenchymal stem cells (MSCs) may be obtained from umbilical cord as an abundant and noninvasive source. However, the immunomodulatory properties of umbilical cord-MSCs (UC-MSCs) were poorly studied. In this study, we aimed to investigate the effects of UC-MSCs on B-cell proliferation and differentiation. UC-MSCs were found to suppress the proliferation of B cells isolated from murine spleen. Moreover, UC-MSCs markedly suppressed B-cell differentiation as shown by the decreased number of CD138+cells and reduced levels of IgM and IgG production in coculture. As revealed by transwell experiments, soluble factors produced by UC-MSCs might be involved in mediating B-cell suppression. The Blimp-1 mRNA expression was suppressed whereas the PAX-5 mRNA expression was induced in coculture. Finally, UC-MSCs modified the phosphorylation pattern of Akt and p38 pathways, which were involved in B-cell proliferation and differentiation. These results may further support the potential therapeutic use of UC-MSCs in treating autoimmune disorders.-
dc.languageeng-
dc.publisherAcademic Press. The Journal's web site is located at http://www.elsevier.com/locate/ycimm-
dc.relation.ispartofCellular Immunology-
dc.subjectB cells-
dc.subjectB-cell proliferation and differentiation-
dc.subjectUmbilical cord mesenchymal stem cells-
dc.titleUmbilical cord mesenchymal stem cells suppress B-cell proliferation and differentiation-
dc.typeArticle-
dc.identifier.openurlhttp://library.hku.hk:4550/resserv?sid=HKU:IR&issn=1090-2163 (Electronic) 0008-8749 (Linkin&volume=274&issue=1-2&spage=46&epage=53&date=2012&atitle=Umbilical+cord+mesenchymal+stem+cells+suppress+B-cell+proliferation+and+differentiationen_US
dc.identifier.emailLu, L: liweilu@hkucc.hku.hk-
dc.identifier.authorityLu, L=rp00477-
dc.identifier.doi10.1016/j.cellimm.2012.02.004-
dc.identifier.pmid22414555-
dc.identifier.scopuseid_2-s2.0-84862789093-
dc.identifier.hkuros208188-
dc.identifier.volume274-
dc.identifier.issue1-2-
dc.identifier.spage46-
dc.identifier.epage53-
dc.identifier.isiWOS:000303694900007-
dc.publisher.placeUnited States-
dc.identifier.citeulike10441272-
dc.identifier.issnl0008-8749-

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