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Article: The t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9

TitleThe t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9
Authors
Borrow, JShearman, AMStanton Jr, VPBecher, RCollins, TWilliams, AJDubé, IKatz, FKwong, YLMorris, COhyashiki, KToyama, KRowley, JHousman, DE
Issue Date1996
PublisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.com
Citation
Nature Genetics, 1996, v. 12 n. 2, p. 159-167 How to Cite?
DOI: http://dx.doi.org/10.1038/ng0296-159
AbstractThe t(7;11)(p15;p15) translocation is a recurrent chromosomal abnormality associated primarily with acute myeloid leukaemia (FAB M2 and M4). We present here the molecular definition of this translocation. On chromosome 7 positional cloning revealed the consistent rearrangement of the HOXA9 gene, which encodes a class I homeodomain protein potentially involved in myeloid differentiation. On chromosome 11 the translocation targets the human homologue of NUP98, a member of the GLFG nucleoporin family. Chimaeric messages spliced over the breakpoint fuse the GLFG repeat domains of NUP98 in-frame to the HOXA9 homeobox. The predicted NUP98-HOXA9 fusion protein may promote leukaemogenesis through inhibition of HOXA9-mediated terminal differentiation and/or aberrant nucleocytoplasmic transport.
Persistent Identifierhttp://hdl.handle.net/10722/163520
ISSN
1061-4036
2021 Impact Factor: 41.307
2020 SCImago Journal Rankings: 18.861
ISI Accession Number ID
WOS:A1996TU07900016
References
References in Scopus

 

DC FieldValueLanguage
dc.contributor.authorBorrow, Jen_US
dc.contributor.authorShearman, AMen_US
dc.contributor.authorStanton Jr, VPen_US
dc.contributor.authorBecher, Ren_US
dc.contributor.authorCollins, Ten_US
dc.contributor.authorWilliams, AJen_US
dc.contributor.authorDubé, Ien_US
dc.contributor.authorKatz, Fen_US
dc.contributor.authorKwong, YLen_US
dc.contributor.authorMorris, Cen_US
dc.contributor.authorOhyashiki, Ken_US
dc.contributor.authorToyama, Ken_US
dc.contributor.authorRowley, Jen_US
dc.contributor.authorHousman, DEen_US
dc.date.accessioned2012-09-05T05:33:03Z-
dc.date.available2012-09-05T05:33:03Z-
dc.date.issued1996en_US
dc.identifier.citationNature Genetics, 1996, v. 12 n. 2, p. 159-167en_US
dc.identifier.issn1061-4036en_US
dc.identifier.urihttp://hdl.handle.net/10722/163520-
dc.description.abstractThe t(7;11)(p15;p15) translocation is a recurrent chromosomal abnormality associated primarily with acute myeloid leukaemia (FAB M2 and M4). We present here the molecular definition of this translocation. On chromosome 7 positional cloning revealed the consistent rearrangement of the HOXA9 gene, which encodes a class I homeodomain protein potentially involved in myeloid differentiation. On chromosome 11 the translocation targets the human homologue of NUP98, a member of the GLFG nucleoporin family. Chimaeric messages spliced over the breakpoint fuse the GLFG repeat domains of NUP98 in-frame to the HOXA9 homeobox. The predicted NUP98-HOXA9 fusion protein may promote leukaemogenesis through inhibition of HOXA9-mediated terminal differentiation and/or aberrant nucleocytoplasmic transport.en_US
dc.languageengen_US
dc.publisherNature Publishing Group. The Journal's web site is located at http://www.genetics.nature.comen_US
dc.relation.ispartofNature Geneticsen_US
dc.subject.meshAmino Acid Sequenceen_US
dc.subject.meshBase Sequenceen_US
dc.subject.meshChromosome Mappingen_US
dc.subject.meshChromosomes, Human, Pair 11en_US
dc.subject.meshChromosomes, Human, Pair 7en_US
dc.subject.meshCloning, Molecularen_US
dc.subject.meshHomeodomain Proteins - Genetics - Physiologyen_US
dc.subject.meshHumansen_US
dc.subject.meshLeukemia, Myelomonocytic, Acute - Geneticsen_US
dc.subject.meshMembrane Proteins - Geneticsen_US
dc.subject.meshMolecular Sequence Dataen_US
dc.subject.meshNuclear Pore Complex Proteinsen_US
dc.subject.meshNuclear Proteins - Geneticsen_US
dc.subject.meshRna, Messenger - Geneticsen_US
dc.subject.meshRna, Neoplasm - Geneticsen_US
dc.subject.meshRepetitive Sequences, Nucleic Acid - Geneticsen_US
dc.subject.meshSequence Analysis, Dnaen_US
dc.subject.meshTranslocation, Geneticen_US
dc.titleThe t(7;11)(p15;p15) translocation in acute myeloid leukaemia fuses the genes for nucleoporin NUP98 and class I homeoprotein HOXA9en_US
dc.typeArticleen_US
dc.identifier.emailKwong, YL:ylkwong@hku.hken_US
dc.identifier.authorityKwong, YL=rp00358en_US
dc.description.naturelink_to_subscribed_fulltexten_US
dc.identifier.doi10.1038/ng0296-159en_US
dc.identifier.pmid8563754-
dc.identifier.scopuseid_2-s2.0-9044249724en_US
dc.identifier.hkuros13463-
dc.relation.referenceshttp://www.scopus.com/mlt/select.url?eid=2-s2.0-9044249724&selection=ref&src=s&origin=recordpageen_US
dc.identifier.volume12en_US
dc.identifier.issue2en_US
dc.identifier.spage159en_US
dc.identifier.epage167en_US
dc.identifier.isiWOS:A1996TU07900016-
dc.publisher.placeUnited Statesen_US
dc.identifier.scopusauthoridBorrow, J=7004496644en_US
dc.identifier.scopusauthoridShearman, AM=6602645935en_US
dc.identifier.scopusauthoridStanton Jr, VP=6604018137en_US
dc.identifier.scopusauthoridBecher, R=35419922900en_US
dc.identifier.scopusauthoridCollins, T=7201800851en_US
dc.identifier.scopusauthoridWilliams, AJ=7405835220en_US
dc.identifier.scopusauthoridDubé, I=7005148762en_US
dc.identifier.scopusauthoridKatz, F=35419872700en_US
dc.identifier.scopusauthoridKwong, YL=7102818954en_US
dc.identifier.scopusauthoridMorris, C=7401472993en_US
dc.identifier.scopusauthoridOhyashiki, K=35379337200en_US
dc.identifier.scopusauthoridToyama, K=35370179600en_US
dc.identifier.scopusauthoridRowley, J=7201756491en_US
dc.identifier.scopusauthoridHousman, DE=7102570207en_US
dc.identifier.issnl1061-4036-

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