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- Publisher Website: 10.1002/bdrc.21004
- Scopus: eid_2-s2.0-84859149207
- PMID: 22457181
- WOS: WOS:000302287800008
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Article: Pluripotent stem cell-based heart regeneration: From the developmental and immunological perspectives
Title | Pluripotent stem cell-based heart regeneration: From the developmental and immunological perspectives |
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Authors | |
Keywords | Esc Heart Development Immunogenicity Ipsc Regenerative Medicine Stem Cells Transplantation |
Issue Date | 2012 |
Publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/102527247 |
Citation | Birth Defects Research Part C - Embryo Today: Reviews, 2012, v. 96 n. 1, p. 98-108 How to Cite? |
Abstract | Heart diseases such as myocardial infarction cause massive loss of cardiomyocytes, but the human heart lacks the innate ability to regenerate. In the adult mammalian heart, a resident progenitor cell population, termed epicardial progenitors, has been identified and reported to stay quiescent under uninjured conditions; however, myocardial infarction induces their proliferation and de novo differentiation into cardiac cells. It is conceivable to develop novel therapeutic approaches for myocardial repair by targeting such expandable sources of cardiac progenitors, thereby giving rise to new muscle and vasculatures. Human pluripotent stem cells such as embryonic stem cells and induced pluripotent stem cells can self-renew and differentiate into the three major cell types of the heart, namely cardiomyocytes, smooth muscle, and endothelial cells. In this review, we describe our current knowledge of the therapeutic potential and challenges associated with the use of pluripotent stem cell and progenitor biology in cell therapy. An emphasis is placed on the contribution of paracrine factors in the growth of myocardium and neovascularization as well as the role of immunogenicity in cell survival and engraftment. © 2012 Wiley Periodicals, Inc. |
Persistent Identifier | http://hdl.handle.net/10722/163471 |
ISSN | 2018 Impact Factor: 3.200 2019 SCImago Journal Rankings: 1.073 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Lui, KO | en_US |
dc.contributor.author | Bu, L | en_US |
dc.contributor.author | Li, RA | en_US |
dc.contributor.author | Chan, CW | en_US |
dc.date.accessioned | 2012-09-05T05:31:46Z | - |
dc.date.available | 2012-09-05T05:31:46Z | - |
dc.date.issued | 2012 | en_US |
dc.identifier.citation | Birth Defects Research Part C - Embryo Today: Reviews, 2012, v. 96 n. 1, p. 98-108 | en_US |
dc.identifier.issn | 1542-975X | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/163471 | - |
dc.description.abstract | Heart diseases such as myocardial infarction cause massive loss of cardiomyocytes, but the human heart lacks the innate ability to regenerate. In the adult mammalian heart, a resident progenitor cell population, termed epicardial progenitors, has been identified and reported to stay quiescent under uninjured conditions; however, myocardial infarction induces their proliferation and de novo differentiation into cardiac cells. It is conceivable to develop novel therapeutic approaches for myocardial repair by targeting such expandable sources of cardiac progenitors, thereby giving rise to new muscle and vasculatures. Human pluripotent stem cells such as embryonic stem cells and induced pluripotent stem cells can self-renew and differentiate into the three major cell types of the heart, namely cardiomyocytes, smooth muscle, and endothelial cells. In this review, we describe our current knowledge of the therapeutic potential and challenges associated with the use of pluripotent stem cell and progenitor biology in cell therapy. An emphasis is placed on the contribution of paracrine factors in the growth of myocardium and neovascularization as well as the role of immunogenicity in cell survival and engraftment. © 2012 Wiley Periodicals, Inc. | en_US |
dc.language | eng | en_US |
dc.publisher | John Wiley & Sons, Inc. The Journal's web site is located at http://www3.interscience.wiley.com/cgi-bin/jhome/102527247 | en_US |
dc.relation.ispartof | Birth Defects Research Part C - Embryo Today: Reviews | en_US |
dc.subject | Esc | en_US |
dc.subject | Heart Development | en_US |
dc.subject | Immunogenicity | en_US |
dc.subject | Ipsc | en_US |
dc.subject | Regenerative Medicine | en_US |
dc.subject | Stem Cells | en_US |
dc.subject | Transplantation | en_US |
dc.title | Pluripotent stem cell-based heart regeneration: From the developmental and immunological perspectives | en_US |
dc.type | Article | en_US |
dc.identifier.email | Bu, L:leibu@hku.hk | en_US |
dc.identifier.email | Lui, OLK: kolui@hku.hk | - |
dc.identifier.email | Li, RA: ronaldli@hkucc.hku.hk | - |
dc.identifier.email | Chan, CWY: camchan@hku.hk | - |
dc.identifier.authority | Bu, L=rp01534 | en_US |
dc.identifier.authority | Li, RA=rp01352 | - |
dc.identifier.authority | Chan, CWY=rp01311 | - |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1002/bdrc.21004 | en_US |
dc.identifier.pmid | 22457181 | - |
dc.identifier.scopus | eid_2-s2.0-84859149207 | en_US |
dc.identifier.hkuros | 207922 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-84859149207&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 96 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.spage | 98 | en_US |
dc.identifier.epage | 108 | en_US |
dc.identifier.isi | WOS:000302287800008 | - |
dc.publisher.place | United States | en_US |
dc.identifier.scopusauthorid | Lui, KO=55153689700 | en_US |
dc.identifier.scopusauthorid | Bu, L=8510445400 | en_US |
dc.identifier.scopusauthorid | Li, RA=55153638000 | en_US |
dc.identifier.scopusauthorid | Chan, CW=55152596100 | en_US |
dc.identifier.issnl | 1542-975X | - |