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- Publisher Website: 10.1159/000327914
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- PMID: 21757911
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Article: Evaluation of performance of measurement of faecal α 1- antitrypsin clearance and technetium-99m human serum albumin scintigraphy in protein-losing enteropathy
Title | Evaluation of performance of measurement of faecal α 1- antitrypsin clearance and technetium-99m human serum albumin scintigraphy in protein-losing enteropathy |
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Authors | |
Keywords | Diagnostic accuracy Diagnostic investigation Gastrointestinal protein loss Validity |
Issue Date | 2011 |
Publisher | S Karger AG. The Journal's web site is located at http://www.karger.com/DIG |
Citation | Digestion, 2011, v. 84 n. 3, p. 199-206 How to Cite? |
Abstract | Background and Aim: Our study aimed to compare the performance of faecal α 1-antitrypsin clearance (AATC) and radiolabelled human serum albumin (HSA) scintigraphy in protein-losing enteropathy (PLE). Methods: Patients studied by both AATC and technetium-99m ( 99mTc)-labelled HSA scintigraphy were recruited and categorized into PLE and non-PLE groups based on clinical and laboratory findings. The performance of AATC and 99mTc-labelled HSA scintigraphy was evaluated using clinical diagnosis of PLE as a gold standard. Results: 29 patients were recruited and 13 patients were considered to have definite PLE (PLE group). In the PLE group, all patients had a positive HSA scinigraphy and 10 (77%) had demonstrable positive tracing in the early phase. Conversely, only 6 of them (46%) had elevated AATC level (>13 m/day). Results of 99mTc-labelled HSA scan (but not AATC) showed significant agreement with the clinical diagnosis (κ 0.35, p = 0.013). 99mTc-labelled HSA scintigraphy carried higher sensitivity (100 vs. 46%) and negative predictive value (100 vs. 63%) compared to AATC in diagnosing PLE. The correlation between the results of these two investigations was only modest (κ 0.27, p = 0.04). The area under the receiver operating characteristic curve of AATC level showed no optimal diagnostic cut-off for PLE. Conclusion: 99mTc-labelled HSA scintigraphy was superior to AATC in diagnosing PLE. © 2011 S. Karger AG, Basel. |
Persistent Identifier | http://hdl.handle.net/10722/163386 |
ISSN | 2023 Impact Factor: 3.0 2023 SCImago Journal Rankings: 0.891 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Chau, TN | en_US |
dc.contributor.author | Mok, MY | en_US |
dc.contributor.author | Chan, EYT | en_US |
dc.contributor.author | Luk, WH | en_US |
dc.contributor.author | Lai, KB | en_US |
dc.contributor.author | Li, FTW | en_US |
dc.contributor.author | Leung, VKS | en_US |
dc.contributor.author | Wong, R | en_US |
dc.date.accessioned | 2012-09-05T05:30:48Z | - |
dc.date.available | 2012-09-05T05:30:48Z | - |
dc.date.issued | 2011 | en_US |
dc.identifier.citation | Digestion, 2011, v. 84 n. 3, p. 199-206 | en_US |
dc.identifier.issn | 0012-2823 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/163386 | - |
dc.description.abstract | Background and Aim: Our study aimed to compare the performance of faecal α 1-antitrypsin clearance (AATC) and radiolabelled human serum albumin (HSA) scintigraphy in protein-losing enteropathy (PLE). Methods: Patients studied by both AATC and technetium-99m ( 99mTc)-labelled HSA scintigraphy were recruited and categorized into PLE and non-PLE groups based on clinical and laboratory findings. The performance of AATC and 99mTc-labelled HSA scintigraphy was evaluated using clinical diagnosis of PLE as a gold standard. Results: 29 patients were recruited and 13 patients were considered to have definite PLE (PLE group). In the PLE group, all patients had a positive HSA scinigraphy and 10 (77%) had demonstrable positive tracing in the early phase. Conversely, only 6 of them (46%) had elevated AATC level (>13 m/day). Results of 99mTc-labelled HSA scan (but not AATC) showed significant agreement with the clinical diagnosis (κ 0.35, p = 0.013). 99mTc-labelled HSA scintigraphy carried higher sensitivity (100 vs. 46%) and negative predictive value (100 vs. 63%) compared to AATC in diagnosing PLE. The correlation between the results of these two investigations was only modest (κ 0.27, p = 0.04). The area under the receiver operating characteristic curve of AATC level showed no optimal diagnostic cut-off for PLE. Conclusion: 99mTc-labelled HSA scintigraphy was superior to AATC in diagnosing PLE. © 2011 S. Karger AG, Basel. | en_US |
dc.language | eng | en_US |
dc.publisher | S Karger AG. The Journal's web site is located at http://www.karger.com/DIG | en_US |
dc.relation.ispartof | Digestion | en_US |
dc.subject | Diagnostic accuracy | - |
dc.subject | Diagnostic investigation | - |
dc.subject | Gastrointestinal protein loss | - |
dc.subject | Validity | - |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Aged, 80 And Over | en_US |
dc.subject.mesh | Child | en_US |
dc.subject.mesh | Feces - Chemistry | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Organotechnetium Compounds - Diagnostic Use | en_US |
dc.subject.mesh | Predictive Value Of Tests | en_US |
dc.subject.mesh | Protein-Losing Enteropathies - Etiology - Metabolism - Radionuclide Imaging | en_US |
dc.subject.mesh | Roc Curve | en_US |
dc.subject.mesh | Retrospective Studies | en_US |
dc.subject.mesh | Serum Albumin - Diagnostic Use - Metabolism | en_US |
dc.subject.mesh | Young Adult | en_US |
dc.subject.mesh | Alpha 1-Antitrypsin - Analysis - Metabolism | en_US |
dc.title | Evaluation of performance of measurement of faecal α 1- antitrypsin clearance and technetium-99m human serum albumin scintigraphy in protein-losing enteropathy | en_US |
dc.type | Article | en_US |
dc.identifier.email | Mok, MY:temy@hkucc.hku.hk | en_US |
dc.identifier.authority | Mok, MY=rp00490 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1159/000327914 | en_US |
dc.identifier.pmid | 21757911 | - |
dc.identifier.scopus | eid_2-s2.0-79960258894 | en_US |
dc.identifier.hkuros | 235706 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-79960258894&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 84 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.spage | 199 | en_US |
dc.identifier.epage | 206 | en_US |
dc.identifier.isi | WOS:000295987400005 | - |
dc.publisher.place | Switzerland | en_US |
dc.identifier.scopusauthorid | Chau, TN=7102000078 | en_US |
dc.identifier.scopusauthorid | Mok, MY=7006024184 | en_US |
dc.identifier.scopusauthorid | Chan, EYT=7401994013 | en_US |
dc.identifier.scopusauthorid | Luk, WH=8229666500 | en_US |
dc.identifier.scopusauthorid | Lai, KB=36614177400 | en_US |
dc.identifier.scopusauthorid | Li, FTW=36466648100 | en_US |
dc.identifier.scopusauthorid | Leung, VKS=7102336049 | en_US |
dc.identifier.scopusauthorid | Wong, R=7402127302 | en_US |
dc.identifier.issnl | 0012-2823 | - |