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Article: KCNQ1 and type 2 diabetes: Study in Hubei Han Chinese and meta-analysis in East Asian populations
Title | KCNQ1 and type 2 diabetes: Study in Hubei Han Chinese and meta-analysis in East Asian populations |
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Authors | |
Keywords | Association KCNQ1 Single nucleotide polmorphism Type 2 diabetes |
Issue Date | 2010 |
Citation | Genes And Genomics, 2010, v. 32 n. 4, p. 327-334 How to Cite? |
Abstract | Recent genome-wide association studies in East Asian poulations reported the association of KCNQ1 variants with type 2 diabetes. In the present study, we first investigated the association between rs2237892 in KCNQ1 and type 2 diabetes in a Hubei Han Chinese population (223 type 2 diabetes patients and 201 controls). The frequencies of CC genotype and C allele in type 2 diabetes patients were significantly higher than those of controls group (CC: 51.6% vs 39.3%, P=0.001; C: 72.2% vs 61.2%, P=0.001). The odds ratio for the risk allele C was 1.65 (95%CI 1.23-2.2, P=0.001). Then, we systematically reviewed the association of SNPs (rs2237892, rs2237895, rs2237897, rs2074196) in KCNQ1 with type 2 diabetes risk in a meta-analysis. Significant heterogeneity between studies was found for SNPs rs2237892 and rs2237897. Combined odds ratios of the rs2237892 C, rs2237895 C, rs2237897 C, rs2074196 G allele were 1.35 (95% CI 1.29-1.41, P<0.0001), 1.27 (95%CI 1.23-1.32, P<0.0001), 1.32 (95%CI 1.21-1.43, P<0.0001), 1.30 (95%CI 1.25-1.35, P<0.0001) respectively. Our results and meta-analysis demonstrated that KCNQ1 polymorphisms were reproducibly associated with the risk of type 2 diabetes in Han Chinese and East Asian populations. © 2010 The Genetics Society of Korea and Springer Netherlands. |
Persistent Identifier | http://hdl.handle.net/10722/163333 |
ISSN | 2023 Impact Factor: 1.6 2023 SCImago Journal Rankings: 0.473 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Dehwah, MAS | en_HK |
dc.contributor.author | Zhang, S | en_HK |
dc.contributor.author | Qu, K | en_HK |
dc.contributor.author | Huang, H | en_HK |
dc.contributor.author | Xu, A | en_HK |
dc.contributor.author | Huang, Q | en_HK |
dc.date.accessioned | 2012-09-05T05:30:08Z | - |
dc.date.available | 2012-09-05T05:30:08Z | - |
dc.date.issued | 2010 | en_HK |
dc.identifier.citation | Genes And Genomics, 2010, v. 32 n. 4, p. 327-334 | en_HK |
dc.identifier.issn | 1976-9571 | en_HK |
dc.identifier.uri | http://hdl.handle.net/10722/163333 | - |
dc.description.abstract | Recent genome-wide association studies in East Asian poulations reported the association of KCNQ1 variants with type 2 diabetes. In the present study, we first investigated the association between rs2237892 in KCNQ1 and type 2 diabetes in a Hubei Han Chinese population (223 type 2 diabetes patients and 201 controls). The frequencies of CC genotype and C allele in type 2 diabetes patients were significantly higher than those of controls group (CC: 51.6% vs 39.3%, P=0.001; C: 72.2% vs 61.2%, P=0.001). The odds ratio for the risk allele C was 1.65 (95%CI 1.23-2.2, P=0.001). Then, we systematically reviewed the association of SNPs (rs2237892, rs2237895, rs2237897, rs2074196) in KCNQ1 with type 2 diabetes risk in a meta-analysis. Significant heterogeneity between studies was found for SNPs rs2237892 and rs2237897. Combined odds ratios of the rs2237892 C, rs2237895 C, rs2237897 C, rs2074196 G allele were 1.35 (95% CI 1.29-1.41, P<0.0001), 1.27 (95%CI 1.23-1.32, P<0.0001), 1.32 (95%CI 1.21-1.43, P<0.0001), 1.30 (95%CI 1.25-1.35, P<0.0001) respectively. Our results and meta-analysis demonstrated that KCNQ1 polymorphisms were reproducibly associated with the risk of type 2 diabetes in Han Chinese and East Asian populations. © 2010 The Genetics Society of Korea and Springer Netherlands. | en_HK |
dc.language | eng | en_US |
dc.relation.ispartof | Genes and Genomics | en_HK |
dc.subject | Association | en_HK |
dc.subject | KCNQ1 | en_HK |
dc.subject | Single nucleotide polmorphism | en_HK |
dc.subject | Type 2 diabetes | en_HK |
dc.title | KCNQ1 and type 2 diabetes: Study in Hubei Han Chinese and meta-analysis in East Asian populations | en_HK |
dc.type | Article | en_HK |
dc.identifier.email | Xu, A: amxu@hkucc.hku.hk | en_HK |
dc.identifier.email | Huang, Q: qyhuang@hotmail.com | en_HK |
dc.identifier.authority | Xu, A=rp00485 | en_HK |
dc.identifier.authority | Huang, Q=rp00521 | en_HK |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1007/s13258-010-0020-y | en_HK |
dc.identifier.scopus | eid_2-s2.0-77956577895 | en_HK |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-77956577895&selection=ref&src=s&origin=recordpage | en_HK |
dc.identifier.volume | 32 | en_HK |
dc.identifier.issue | 4 | en_HK |
dc.identifier.spage | 327 | en_HK |
dc.identifier.epage | 334 | en_HK |
dc.identifier.isi | WOS:000281669200005 | - |
dc.identifier.scopusauthorid | Dehwah, MAS=24070520600 | en_HK |
dc.identifier.scopusauthorid | Zhang, S=36699057700 | en_HK |
dc.identifier.scopusauthorid | Qu, K=36698871300 | en_HK |
dc.identifier.scopusauthorid | Huang, H=14627541100 | en_HK |
dc.identifier.scopusauthorid | Xu, A=7202655409 | en_HK |
dc.identifier.scopusauthorid | Huang, Q=7403630787 | en_HK |
dc.identifier.issnl | 1976-9571 | - |