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- Publisher Website: 10.1111/j.1440-1746.2009.05861.x
- Scopus: eid_2-s2.0-66549124137
- PMID: 19638089
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Article: Reflux profile of Chinese gastroesophageal reflux disease patients with combined multichannel intraluminal impedance-pH monitoring
Title | Reflux profile of Chinese gastroesophageal reflux disease patients with combined multichannel intraluminal impedance-pH monitoring |
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Authors | |
Keywords | Combined multichannel intraluminal impedance-pH monitoring Erosive esophagitis Functional heartburn Gastroesophageal reflux disease Non-erosive reflux disease |
Issue Date | 2009 |
Publisher | Wiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH |
Citation | Journal Of Gastroenterology And Hepatology, 2009, v. 24 n. 6, p. 1113-1118 How to Cite? |
Abstract | Background and Aims: To investigate the reflux profile of Chinese gastroesophageal reflux disease (GERD) patients with the aid of combined multichannel intraluminal impedance-pH (MII-pH) monitoring technique. Methods: Consecutive patients presented with GERD symptoms were enrolled to erosive esophagitis (EE) group, non-erosive reflux disease (NERD) group and functional heartburn (FH) group after upper endoscopy, combined MII-pH monitoring and rabeprazole test. Another 20 healthy controls (HC) were recruited. Results: Sixty-four GERD patients (EE:20, NERD:22, FH:22, HC:20) were enrolled. There were more episodes of liquid reflux and proximal reflux in EE and NERD groups than that in FH and HC groups (P < 0.05). Patients in FH and HC groups had higher proportion of mixed reflux (P = 0.000). The percentage of acid reflux in EE and NERD was much higher, while there was a higher percentage of weakly acidic reflux in FH and HC (P = 0.000). No significant difference was found in MII-pH parameters between groups with and without response to rabeprazole test except recumbent percentage time of esophageal pH value below 4 and episodes of proximal reflux. Conclusion: Erosive esophagitis and NERD patients had more liquid and proximal reflux episodes than FH patients and healthy controls. Acid and liquid reflux was predominant in the former two groups, while weakly acidic and mixed reflux was predominant in the latter two groups. © 2009 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd. |
Persistent Identifier | http://hdl.handle.net/10722/163250 |
ISSN | 2023 Impact Factor: 3.7 2023 SCImago Journal Rankings: 1.179 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Xiao, YL | en_US |
dc.contributor.author | Lin, JK | en_US |
dc.contributor.author | Cheung, TK | en_US |
dc.contributor.author | Wong, NYH | en_US |
dc.contributor.author | Hung, IFN | en_US |
dc.contributor.author | Wong, BCY | en_US |
dc.contributor.author | Peng, S | en_US |
dc.contributor.author | Wang, AJ | en_US |
dc.contributor.author | Chen, MH | en_US |
dc.date.accessioned | 2012-09-05T05:29:08Z | - |
dc.date.available | 2012-09-05T05:29:08Z | - |
dc.date.issued | 2009 | en_US |
dc.identifier.citation | Journal Of Gastroenterology And Hepatology, 2009, v. 24 n. 6, p. 1113-1118 | en_US |
dc.identifier.issn | 0815-9319 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/163250 | - |
dc.description.abstract | Background and Aims: To investigate the reflux profile of Chinese gastroesophageal reflux disease (GERD) patients with the aid of combined multichannel intraluminal impedance-pH (MII-pH) monitoring technique. Methods: Consecutive patients presented with GERD symptoms were enrolled to erosive esophagitis (EE) group, non-erosive reflux disease (NERD) group and functional heartburn (FH) group after upper endoscopy, combined MII-pH monitoring and rabeprazole test. Another 20 healthy controls (HC) were recruited. Results: Sixty-four GERD patients (EE:20, NERD:22, FH:22, HC:20) were enrolled. There were more episodes of liquid reflux and proximal reflux in EE and NERD groups than that in FH and HC groups (P < 0.05). Patients in FH and HC groups had higher proportion of mixed reflux (P = 0.000). The percentage of acid reflux in EE and NERD was much higher, while there was a higher percentage of weakly acidic reflux in FH and HC (P = 0.000). No significant difference was found in MII-pH parameters between groups with and without response to rabeprazole test except recumbent percentage time of esophageal pH value below 4 and episodes of proximal reflux. Conclusion: Erosive esophagitis and NERD patients had more liquid and proximal reflux episodes than FH patients and healthy controls. Acid and liquid reflux was predominant in the former two groups, while weakly acidic and mixed reflux was predominant in the latter two groups. © 2009 Journal of Gastroenterology and Hepatology Foundation and Blackwell Publishing Asia Pty Ltd. | en_US |
dc.language | eng | en_US |
dc.publisher | Wiley-Blackwell Publishing Asia. The Journal's web site is located at http://www.blackwellpublishing.com/journals/JGH | en_US |
dc.relation.ispartof | Journal of Gastroenterology and Hepatology | en_US |
dc.subject | Combined multichannel intraluminal impedance-pH monitoring | - |
dc.subject | Erosive esophagitis | - |
dc.subject | Functional heartburn | - |
dc.subject | Gastroesophageal reflux disease | - |
dc.subject | Non-erosive reflux disease | - |
dc.subject.mesh | 2-Pyridinylmethylsulfinylbenzimidazoles - Therapeutic Use | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Analysis Of Variance | en_US |
dc.subject.mesh | Anti-Ulcer Agents - Therapeutic Use | en_US |
dc.subject.mesh | Case-Control Studies | en_US |
dc.subject.mesh | Chi-Square Distribution | en_US |
dc.subject.mesh | China - Epidemiology | en_US |
dc.subject.mesh | Esophageal Ph Monitoring - Instrumentation | en_US |
dc.subject.mesh | Esophagitis - Drug Therapy - Epidemiology - Physiopathology | en_US |
dc.subject.mesh | Esophagoscopy | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Gastroesophageal Reflux - Drug Therapy - Epidemiology - Physiopathology | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Statistics, Nonparametric | en_US |
dc.subject.mesh | Treatment Outcome | en_US |
dc.title | Reflux profile of Chinese gastroesophageal reflux disease patients with combined multichannel intraluminal impedance-pH monitoring | en_US |
dc.type | Article | en_US |
dc.identifier.email | Hung, IFN:ivanhung@hkucc.hku.hk | en_US |
dc.identifier.email | Wong, BCY:bcywong@hku.hk | en_US |
dc.identifier.authority | Hung, IFN=rp00508 | en_US |
dc.identifier.authority | Wong, BCY=rp00429 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1111/j.1440-1746.2009.05861.x | en_US |
dc.identifier.pmid | 19638089 | - |
dc.identifier.scopus | eid_2-s2.0-66549124137 | en_US |
dc.identifier.hkuros | 179945 | - |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-66549124137&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 24 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.spage | 1113 | en_US |
dc.identifier.epage | 1118 | en_US |
dc.identifier.isi | WOS:000266465000032 | - |
dc.publisher.place | Australia | en_US |
dc.identifier.scopusauthorid | Xiao, YL=23500436000 | en_US |
dc.identifier.scopusauthorid | Lin, JK=8065241700 | en_US |
dc.identifier.scopusauthorid | Cheung, TK=7103334158 | en_US |
dc.identifier.scopusauthorid | Wong, NYH=7202836655 | en_US |
dc.identifier.scopusauthorid | Hung, IFN=7006103457 | en_US |
dc.identifier.scopusauthorid | Wong, BCY=7402023340 | en_US |
dc.identifier.scopusauthorid | Peng, S=8454524700 | en_US |
dc.identifier.scopusauthorid | Wang, AJ=24462861200 | en_US |
dc.identifier.scopusauthorid | Chen, MH=8642044500 | en_US |
dc.identifier.citeulike | 4741092 | - |
dc.identifier.issnl | 0815-9319 | - |