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Article: Expression of Cdx2 and claudin-2 in the multistage tissue of gastric carcinogenesis
Title | Expression of Cdx2 and claudin-2 in the multistage tissue of gastric carcinogenesis |
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Authors | |
Keywords | Carcinogenesis Cdx2 Claudin-2 Immunohistochemistry Multistage tissue |
Issue Date | 2008 |
Publisher | S Karger AG. The Journal's web site is located at http://www.karger.com/OCL |
Citation | Oncology, 2008, v. 73 n. 5-6, p. 357-365 How to Cite? |
Abstract | In this paper, we investigated Cdx2 and claudin-2 expression in pathological paraffin tissues of sinus ventriculi from gastroscopic biopsy to determine the correlation between the expressions of these 2 genes during gastric carcinogenesis by immunochemical ABC technique. Altogether, we analyzed 108 chronic superficial gastritis, 55 chronic atrophic gastritis, 109 intestinal-type metaplasia, 93 dysplasia and 52 gastric intestinal-type adenocarcinoma samples. Our results indicated that the percentage of Cdx2-positive cases was 0% (0/108) for chronic superficial gastritis, 0% (0/55) for chronic atrophic gastritis, 90.83% (99/109) for intestinal-type metaplasia, 51.61% (48/93) for dysplasia and 61.54% (32/52) for gastric intestinal-type adenocarcinoma, primarily expressed in the cell nucleus and partly in the cytoplasm (p < 0.05); interestingly, the percentage for the intestine-type metaplasia was markedly high. The percentage of claudin-2-positive cases was 0% (0/108) for chronic superficial gastritis, 0% (0/55) for chronic atrophic gastritis, 0% (0/109) for intestinal-type metaplasia, 35.48% (33/93) for dysplasia and 71.15% (37/52) for gastric intestinal-type adenocarcinoma, primarily in the cell membrane and gradually increased in the multistage process of gastric carcinogenesis (p < 0.05). Significant correlations were found between claudin-2 and Cdx2 protein expression in dysplasia and intestine-type adenocarcinoma (r = 0.112, p < 0.05). Thus, there may be a correlation between the expression of claudin-2 and Cdx2 in stages of dysplasia and cancer. Copyright © 2008 S. Karger AG. |
Persistent Identifier | http://hdl.handle.net/10722/163178 |
ISSN | 2023 Impact Factor: 2.5 2023 SCImago Journal Rankings: 0.832 |
ISI Accession Number ID | |
References |
DC Field | Value | Language |
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dc.contributor.author | Xin, S | en_US |
dc.contributor.author | Huixin, C | en_US |
dc.contributor.author | Benchang, S | en_US |
dc.contributor.author | Aiping, B | en_US |
dc.contributor.author | Jinhui, W | en_US |
dc.contributor.author | Xiaoyan, L | en_US |
dc.contributor.author | Yu, WBC | en_US |
dc.contributor.author | Minhu, C | en_US |
dc.date.accessioned | 2012-09-05T05:28:27Z | - |
dc.date.available | 2012-09-05T05:28:27Z | - |
dc.date.issued | 2008 | en_US |
dc.identifier.citation | Oncology, 2008, v. 73 n. 5-6, p. 357-365 | en_US |
dc.identifier.issn | 0030-2414 | en_US |
dc.identifier.uri | http://hdl.handle.net/10722/163178 | - |
dc.description.abstract | In this paper, we investigated Cdx2 and claudin-2 expression in pathological paraffin tissues of sinus ventriculi from gastroscopic biopsy to determine the correlation between the expressions of these 2 genes during gastric carcinogenesis by immunochemical ABC technique. Altogether, we analyzed 108 chronic superficial gastritis, 55 chronic atrophic gastritis, 109 intestinal-type metaplasia, 93 dysplasia and 52 gastric intestinal-type adenocarcinoma samples. Our results indicated that the percentage of Cdx2-positive cases was 0% (0/108) for chronic superficial gastritis, 0% (0/55) for chronic atrophic gastritis, 90.83% (99/109) for intestinal-type metaplasia, 51.61% (48/93) for dysplasia and 61.54% (32/52) for gastric intestinal-type adenocarcinoma, primarily expressed in the cell nucleus and partly in the cytoplasm (p < 0.05); interestingly, the percentage for the intestine-type metaplasia was markedly high. The percentage of claudin-2-positive cases was 0% (0/108) for chronic superficial gastritis, 0% (0/55) for chronic atrophic gastritis, 0% (0/109) for intestinal-type metaplasia, 35.48% (33/93) for dysplasia and 71.15% (37/52) for gastric intestinal-type adenocarcinoma, primarily in the cell membrane and gradually increased in the multistage process of gastric carcinogenesis (p < 0.05). Significant correlations were found between claudin-2 and Cdx2 protein expression in dysplasia and intestine-type adenocarcinoma (r = 0.112, p < 0.05). Thus, there may be a correlation between the expression of claudin-2 and Cdx2 in stages of dysplasia and cancer. Copyright © 2008 S. Karger AG. | en_US |
dc.language | eng | en_US |
dc.publisher | S Karger AG. The Journal's web site is located at http://www.karger.com/OCL | en_US |
dc.relation.ispartof | Oncology | en_US |
dc.subject | Carcinogenesis | - |
dc.subject | Cdx2 | - |
dc.subject | Claudin-2 | - |
dc.subject | Immunohistochemistry | - |
dc.subject | Multistage tissue | - |
dc.subject.mesh | Adenocarcinoma - Pathology | en_US |
dc.subject.mesh | Adolescent | en_US |
dc.subject.mesh | Adult | en_US |
dc.subject.mesh | Aged | en_US |
dc.subject.mesh | Aged, 80 And Over | en_US |
dc.subject.mesh | Female | en_US |
dc.subject.mesh | Gastritis - Pathology | en_US |
dc.subject.mesh | Homeodomain Proteins - Metabolism | en_US |
dc.subject.mesh | Humans | en_US |
dc.subject.mesh | Immunohistochemistry | en_US |
dc.subject.mesh | Intestinal Neoplasms - Pathology | en_US |
dc.subject.mesh | Male | en_US |
dc.subject.mesh | Membrane Proteins - Metabolism | en_US |
dc.subject.mesh | Metaplasia - Parasitology | en_US |
dc.subject.mesh | Middle Aged | en_US |
dc.subject.mesh | Neoplasm Staging | en_US |
dc.subject.mesh | Stomach Neoplasms - Pathology | en_US |
dc.title | Expression of Cdx2 and claudin-2 in the multistage tissue of gastric carcinogenesis | en_US |
dc.type | Article | en_US |
dc.identifier.email | Yu, WBC:bcywong@hku.hk | en_US |
dc.identifier.authority | Yu, WBC=rp00429 | en_US |
dc.description.nature | link_to_subscribed_fulltext | en_US |
dc.identifier.doi | 10.1159/000135351 | en_US |
dc.identifier.pmid | 18500171 | - |
dc.identifier.scopus | eid_2-s2.0-45549103908 | en_US |
dc.relation.references | http://www.scopus.com/mlt/select.url?eid=2-s2.0-45549103908&selection=ref&src=s&origin=recordpage | en_US |
dc.identifier.volume | 73 | en_US |
dc.identifier.issue | 5-6 | en_US |
dc.identifier.spage | 357 | en_US |
dc.identifier.epage | 365 | en_US |
dc.identifier.isi | WOS:000256880100013 | - |
dc.publisher.place | Switzerland | en_US |
dc.identifier.scopusauthorid | Xin, S=36883450600 | en_US |
dc.identifier.scopusauthorid | Huixin, C=24390822000 | en_US |
dc.identifier.scopusauthorid | Benchang, S=24390659500 | en_US |
dc.identifier.scopusauthorid | Aiping, B=24390454500 | en_US |
dc.identifier.scopusauthorid | Jinhui, W=17434828000 | en_US |
dc.identifier.scopusauthorid | Xiaoyan, L=36794351900 | en_US |
dc.identifier.scopusauthorid | Yu, WBC=7402023340 | en_US |
dc.identifier.scopusauthorid | Minhu, C=15065636400 | en_US |
dc.identifier.issnl | 0030-2414 | - |